Neurosurgical Intracerebral Hemorrhage Evacuation (NICHE) Robot

神经外科脑出血清除(NICHE)机器人

基本信息

  • 批准号:
    9327628
  • 负责人:
  • 金额:
    $ 10.11万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-06-01 至 2018-05-31
  • 项目状态:
    已结题

项目摘要

Project Summary Spontaneous supratentorial intracerebral hemorrhage (ICH) occurs in ≈2 million people worldwide every year and represents a major global public-health problem. ICH is associated with a 30-day mortality rate of 32–50%, and 6 month functional independence is achieved in only 20–25% of individuals who survive such hemorrhages. It is widely accepted that removal of the blood clot should be an important goal of early management of patients with ICH, but despite theoretical benefits, classic craniotomy for ICH removal remains controversial, because clear evidence of efficacy is lacking. Minimally invasive surgery (MIS) causes minimal trauma to brain tissues and significantly improves the number of functionally independent patients at 90 days. However, this apparent benefit is largely negated by high rates of rebleeding. Current technologies to remove ICH have serious limitations. All currently available methods of MIS for ICH evacuation employ line-of-sight, rigid tubes. Because of this, they generally rely on enzymatic thrombolytic agents [e.g., urokinase or tissue plasminogen activator (rtPA)] introduced into the clot to liquefy it, prior to irrigating it out. There are two important limitations with enzymatic thrombolysis. First, it is very slow, requiring multiple injections of thrombolytic agents and more than 24 hours to reduce ICH volume. Therefore, the potential benefit of rapidly reducing intracranial pressure, which can be lifesaving, is completely lost. In addition, enzymatic thrombolysis can be dangerous, since there is no control over where the thrombolytic agent diffuses and thus re-hemorrhage rates are unacceptably high. There is a clear and urgent need to develop an alternative technology for evacuation of ICH without increasing the risk of rebleeding. We envision a Neurosurgical Intracerebral Hemorrhage Evacuation (NICHE) robot for ICH removal that will be: a) compatible with the imaging modality, b) 6 mm in diameter and about 20 cm long to allow deployment into a deep ICH in the basal ganglia or thalamus via non-eloquent frontal lobe cortex rostral to the coronal suture, c) discretely actuated with multiple degrees-of-freedom (DOFs) and the tip link of the robot having the capability to bend into a “J-shape” to allow ICH removal outside of the line-of-sight trajectory and additional joints to allow positioning the tip link within the ICH, d) equipped with suction and irrigation lines running through its hollow core and have bipolar electrocautery probes to liquefy the ICH, and e) under the immediate and direct guidance of the neurosurgeon at all times. To realize the NICHE robot, we will address three specific aims: 1) Design and develop a multi-joint discretely actuated and steerable NICHE robot with bipolar electrocautery probes and a suction and irrigation channel for electrocauterizing the ICH, 2) Develop an intra-operative imaging algorithm for precise, real-time tracking of robotic cannula and to monitor the progress of ICH evacuation using low radiation dose cone-beam CT, and 3) Demonstrate the safety and efficacy of NICHE robot in clinically relevant models of ICH.
项目总结

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Development of a Meso-Scale SMA-Based Torsion Actuator for Image-Guided Procedures.
Development of a Meso-Scale Fiberoptic Rotation Sensor for a Torsion Actuator.
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JAYDEV P. DESAI其他文献

JAYDEV P. DESAI的其他文献

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{{ truncateString('JAYDEV P. DESAI', 18)}}的其他基金

Steerable Robotic Endoscopic Tools for Pediatric Neurosurgery
用于小儿神经外科的可操纵机器人内窥镜工具
  • 批准号:
    10217219
  • 财政年份:
    2020
  • 资助金额:
    $ 10.11万
  • 项目类别:
Steerable Robotic Endoscopic Tools for Pediatric Neurosurgery
用于小儿神经外科的可操纵机器人内窥镜工具
  • 批准号:
    10063219
  • 财政年份:
    2020
  • 资助金额:
    $ 10.11万
  • 项目类别:
Ultrasound-guided, Robotically Steerable Guidewire for Endovascular Interventions
用于血管内介入治疗的超声引导机器人可操纵导丝
  • 批准号:
    9914884
  • 财政年份:
    2019
  • 资助金额:
    $ 10.11万
  • 项目类别:
Ultrasound-guided, Robotically Steerable Guidewire for Endovascular Interventions
用于血管内介入治疗的超声引导机器人可操纵导丝
  • 批准号:
    10155555
  • 财政年份:
    2019
  • 资助金额:
    $ 10.11万
  • 项目类别:
Ultrasound-guided, Robotically Steerable Guidewire for Endovascular Interventions
用于血管内介入治疗的超声引导机器人可操纵导丝
  • 批准号:
    10392386
  • 财政年份:
    2019
  • 资助金额:
    $ 10.11万
  • 项目类别:
Image-guided Intravascular Robotic System for Mitral Valve Repair and Implants
用于二尖瓣修复和植入的图像引导血管内机器人系统
  • 批准号:
    10117090
  • 财政年份:
    2018
  • 资助金额:
    $ 10.11万
  • 项目类别:
Identification of AF Ablation Targets via a Steerable Actuated Catheter(AFIB)
通过可操纵驱动导管 (AFIB) 识别 AF 消融目标
  • 批准号:
    9327633
  • 财政年份:
    2015
  • 资助金额:
    $ 10.11万
  • 项目类别:
Identification of AF Ablation Targets via a Steerable Actuated Catheter
通过可操纵驱动导管识别 AF 消融目标
  • 批准号:
    8893523
  • 财政年份:
    2015
  • 资助金额:
    $ 10.11万
  • 项目类别:
Neurosurgical Intracerebral Hemorrhage Evacuation (NICHE) Robot
神经外科脑出血清除(NICHE)机器人
  • 批准号:
    8853860
  • 财政年份:
    2014
  • 资助金额:
    $ 10.11万
  • 项目类别:
Neurosurgical Intracerebral Hemorrhage Evacuation (NICHE) Robot
神经外科脑出血清除(NICHE)机器人
  • 批准号:
    8684084
  • 财政年份:
    2014
  • 资助金额:
    $ 10.11万
  • 项目类别:

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