Assembly and Function of Olfactory Circuitry from Dbxl-derived Neural Progenitors

Dbxl 衍生神经祖细胞嗅觉回路的组装和功能

• 批准号: 8793781
• 负责人: JOSHUA G CORBIN
• 金额: $ 35.27万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-02-01 至 2016-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8793781
• 关键词: Aggressive behavior; Autistic Disorder; Behavior; Behavioral; Biological Models; Brain; Collaborations; Complex; Cues; Data; Destinations; Development; Disease; Electrophysiology (science); Embryo; Embryonic Development; Gene Expression; Generations; Genes; Genetic; Health; Hormonal; Human; Instinct; Knowledge; Label; Limbic System; Link; Maps; Mediating; Methodology; Modeling; Molecular; Mus; Mutant Strains Mice; Neurons; Neurosciences; Olfactory Epithelium; Olfactory Pathways; Output; Pattern; Pheromone; Population; Process; Reproduction; Research Personnel; Route; Schizophrenia; Sensory; Shapes; Source; Specific qualifier value; Specificity; Stimulus; Stream; Telencephalon; Testing; autism spectrum disorder; base; behavior test; developmental disease; feeding; homeodomain; information processing; insight; interdisciplinary approach; multidisciplinary; nerve stem cell; neural patterning; neurogenesis; neuronal patterning; novel; olfactory bulb; optogenetics; progenitor; programs; relating to nervous system; reproductive; research study; sensory system; social; transcription factor; vomeronasal organ

DESCRIPTION (provided by applicant): How neural developmental programs are linked to the establishment of mature brain circuits and related behavior remains a central question of neuroscience. Our previous studies revealed that a class of neural progenitors defined by the expression of the homeodomain encoding transcription factor, Dbx1, are dedicated for the generation of subsets of neurons of the limbic system including the olfactory bulb. Based on these findings, we hypothesize that Dbx1+ progenitors located in a distinct embryonic niche generate a functionally distinct interconnected subset of olfactory bulb output neurons that are dedicated to the processing of subsets of innate behaviors. Testing of this hypothesis will be accomplished using a combination of multidisciplinary approaches including genetic fate mapping, optogenetics and innate behavioral testing.

描述（由申请人提供）：神经发育程序如何与成熟脑回路和相关行为的建立相关联仍然是神经科学的中心问题。我们以前的研究表明，一类定义的同源结构域编码转录因子，Dbx1的表达的神经祖细胞，是专门为包括嗅球的边缘系统的神经元的子集的产生。基于这些发现，我们假设Dbx1+祖细胞位于一个不同的胚胎龛产生一个功能不同的互连子集的嗅球输出神经元，致力于处理的先天行为的子集。这一假设的检验将使用多学科方法的组合来完成，包括遗传命运作图、光遗传学和先天行为测试。