Assembly and Function of Olfactory Circuitry from Dbxl-derived Neural Progenitors
Dbxl 衍生神经祖细胞嗅觉回路的组装和功能
基本信息
- 批准号:8793781
- 负责人:
- 金额:$ 35.27万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-02-01 至 2016-01-31
- 项目状态:已结题
- 来源:
- 关键词:Aggressive behaviorAutistic DisorderBehaviorBehavioralBiological ModelsBrainCollaborationsComplexCuesDataDestinationsDevelopmentDiseaseElectrophysiology (science)EmbryoEmbryonic DevelopmentGene ExpressionGenerationsGenesGeneticHealthHormonalHumanInstinctKnowledgeLabelLimbic SystemLinkMapsMediatingMethodologyModelingMolecularMusMutant Strains MiceNeuronsNeurosciencesOlfactory EpitheliumOlfactory PathwaysOutputPatternPheromonePopulationProcessReproductionResearch PersonnelRouteSchizophreniaSensoryShapesSourceSpecific qualifier valueSpecificityStimulusStreamTelencephalonTestingautism spectrum disorderbasebehavior testdevelopmental diseasefeedinghomeodomaininformation processinginsightinterdisciplinary approachmultidisciplinarynerve stem cellneural patterningneurogenesisneuronal patterningnovelolfactory bulboptogeneticsprogenitorprogramsrelating to nervous systemreproductiveresearch studysensory systemsocialtranscription factorvomeronasal organ
项目摘要
DESCRIPTION (provided by applicant): How neural developmental programs are linked to the establishment of mature brain circuits and related behavior remains a central question of neuroscience. Our previous studies revealed that a class of neural progenitors defined by the expression of the homeodomain encoding transcription factor, Dbx1, are dedicated for the generation of subsets of neurons of the limbic system including the olfactory bulb. Based on these findings, we hypothesize that Dbx1+ progenitors located in a distinct embryonic niche generate a functionally distinct interconnected subset of olfactory bulb output neurons that are dedicated to the processing of subsets of innate behaviors. Testing of this hypothesis will be accomplished using a combination of multidisciplinary approaches including genetic fate mapping, optogenetics and innate behavioral testing.
描述(由申请人提供):神经发育程序如何与成熟脑回路和相关行为的建立相关联仍然是神经科学的中心问题。我们以前的研究表明,一类定义的同源结构域编码转录因子,Dbx1的表达的神经祖细胞,是专门为包括嗅球的边缘系统的神经元的子集的产生。基于这些发现,我们假设Dbx1+祖细胞位于一个不同的胚胎龛产生一个功能不同的互连子集的嗅球输出神经元,致力于处理的先天行为的子集。这一假设的检验将使用多学科方法的组合来完成,包括遗传命运作图、光遗传学和先天行为测试。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JOSHUA G CORBIN其他文献
JOSHUA G CORBIN的其他文献
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{{ truncateString('JOSHUA G CORBIN', 18)}}的其他基金
Cellular and transcriptomic programs linking amygdala progenitors to mature neuronal identity
将杏仁核祖细胞与成熟神经元身份联系起来的细胞和转录组程序
- 批准号:
10751113 - 财政年份:2022
- 资助金额:
$ 35.27万 - 项目类别:
Cellular and transcriptomic programs linking amygdala progenitors to mature neuronal identity
将杏仁核祖细胞与成熟神经元身份联系起来的细胞和转录组程序
- 批准号:
10570992 - 财政年份:2022
- 资助金额:
$ 35.27万 - 项目类别:
Cellular and transcriptomic programs linking amygdala progenitors to mature neuronal identity
将杏仁核祖细胞与成熟神经元身份联系起来的细胞和转录组程序
- 批准号:
10430617 - 财政年份:2022
- 资助金额:
$ 35.27万 - 项目类别:
Origin and timing of development of late-maturing neurons in the amygdala
杏仁核晚熟神经元发育的起源和时间
- 批准号:
10116629 - 财政年份:2020
- 资助金额:
$ 35.27万 - 项目类别:
Origin and timing of development of late-maturing neurons in the amygdala
杏仁核晚熟神经元发育的起源和时间
- 批准号:
10262956 - 财政年份:2020
- 资助金额:
$ 35.27万 - 项目类别:
Assembly and Function of Olfactory Circuitry from Dbxl-derived Neural Progenitors
Dbxl 衍生神经祖细胞嗅觉回路的组装和功能
- 批准号:
8610912 - 财政年份:2013
- 资助金额:
$ 35.27万 - 项目类别:
Assembly and Function of Olfactory Circuitry from Dbxl-derived Neural Progenitors
Dbxl 衍生神经祖细胞嗅觉回路的组装和功能
- 批准号:
9229549 - 财政年份:2013
- 资助金额:
$ 35.27万 - 项目类别:
Assembly and Function of Olfactory Circuitry from Dbxl-derived Neural Progenitors
Dbxl 衍生神经祖细胞嗅觉回路的组装和功能
- 批准号:
8506230 - 财政年份:2013
- 资助金额:
$ 35.27万 - 项目类别:
Development of the basal telencephalic limbic system
基础端脑边缘系统的发育
- 批准号:
7821751 - 财政年份:2009
- 资助金额:
$ 35.27万 - 项目类别:
Development of the Basal Telencephalic Limbic System
基底端脑边缘系统的发育
- 批准号:
8040686 - 财政年份:2006
- 资助金额:
$ 35.27万 - 项目类别:
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