Origin and timing of development of late-maturing neurons in the amygdala

杏仁核晚熟神经元发育的起源和时间

基本信息

  • 批准号:
    10262956
  • 负责人:
  • 金额:
    $ 20.91万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-09-15 至 2022-08-31
  • 项目状态:
    已结题

项目摘要

Project Summary The amygdala is a major processing center for emotional and social behaviors, aspects of which are altered in developmental disorders such as Autism Spectrum Disorders (ASD). In humans, the paralaminar nucleus of the amygdala (PL), located adjacent to basolateral amygdala amygdala (BLA), contains a large population of immature neurons that persist into post-natal stages, well past the maturational time course of the overwhelming majority of neurons in the brain. Our recent studies have revealed that human PL neurons mature prominently during childhood and adolescence (Sorrells et al., Nature Communications, 2019). This raises the intriguing possibility that these neurons are essential for social/emotional changes that occur during critical periods of postnatal development. Our preliminary data reveal that this population is also present in mice. This opens up an exciting opportunity to use the mouse to model this interesting neuronal population. The goals of this exploratory R21 application are to: 1) characterize the post-natal morphological, molecular and electrophysiological maturational profiles of mouse PL neurons during the pre-pubertal critical period temporally coinciding with emergence of emotional processing in humans and 2) determine the developmental timing and origin of mouse PL neurons. As embryonic origin and identity are intimately tied to adult neuronal function, these studies are also a important first step to ultimately dissecting neural connectivity, function and role that these specialized cells play in neuro-typical and -atypical social-emotional development.
项目摘要 杏仁核是情绪和社会行为的主要处理中心, 在自闭症谱系障碍(ASD)等发育障碍中发生改变。在人类中, 杏仁核内侧核(PL),位于基底外侧杏仁核附近 杏仁核(BLA)包含大量未成熟的神经元,这些神经元持续到出生后 阶段,远远超过了绝大多数神经元的成熟时间过程。 个脑袋我们最近的研究表明,人类PL神经元在 童年和青春期(Sorrells等人,Nature Communications,2019)。这就提出了一个 有趣的可能性是,这些神经元对发生在大脑中的社会/情感变化至关重要, 在产后发育的关键时期。我们的初步数据显示, 种群也存在于小鼠中。这为我们提供了一个激动人心的机会, 模拟这个有趣的神经元群体。此探索性R21应用程序的目标是: 1)表征出生后的形态,分子和电生理 小鼠PL神经元在青春期前关键期的成熟特征 时间上与人类情感处理的出现相一致,2) 确定小鼠PL神经元的发育时间和起源。作为胚胎起源 和身份与成人神经元功能密切相关,这些研究也是重要的第一次。 最终解剖神经连接,功能和作用,这些专门的细胞 在神经典型和非典型社会情感发展中发挥作用。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

JOSHUA G CORBIN其他文献

JOSHUA G CORBIN的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('JOSHUA G CORBIN', 18)}}的其他基金

Cellular and transcriptomic programs linking amygdala progenitors to mature neuronal identity
将杏仁核祖细胞与成熟神经元身份联系起来的细胞和转录组程序
  • 批准号:
    10751113
  • 财政年份:
    2022
  • 资助金额:
    $ 20.91万
  • 项目类别:
Cellular and transcriptomic programs linking amygdala progenitors to mature neuronal identity
将杏仁核祖细胞与成熟神经元身份联系起来的细胞和转录组程序
  • 批准号:
    10570992
  • 财政年份:
    2022
  • 资助金额:
    $ 20.91万
  • 项目类别:
Cellular and transcriptomic programs linking amygdala progenitors to mature neuronal identity
将杏仁核祖细胞与成熟神经元身份联系起来的细胞和转录组程序
  • 批准号:
    10430617
  • 财政年份:
    2022
  • 资助金额:
    $ 20.91万
  • 项目类别:
Origin and timing of development of late-maturing neurons in the amygdala
杏仁核晚熟神经元发育的起源和时间
  • 批准号:
    10116629
  • 财政年份:
    2020
  • 资助金额:
    $ 20.91万
  • 项目类别:
Assembly and Function of Olfactory Circuitry from Dbxl-derived Neural Progenitors
Dbxl 衍生神经祖细胞嗅觉回路的组装和功能
  • 批准号:
    8610912
  • 财政年份:
    2013
  • 资助金额:
    $ 20.91万
  • 项目类别:
Assembly and Function of Olfactory Circuitry from Dbxl-derived Neural Progenitors
Dbxl 衍生神经祖细胞嗅觉回路的组装和功能
  • 批准号:
    8793781
  • 财政年份:
    2013
  • 资助金额:
    $ 20.91万
  • 项目类别:
Assembly and Function of Olfactory Circuitry from Dbxl-derived Neural Progenitors
Dbxl 衍生神经祖细胞嗅觉回路的组装和功能
  • 批准号:
    8506230
  • 财政年份:
    2013
  • 资助金额:
    $ 20.91万
  • 项目类别:
Assembly and Function of Olfactory Circuitry from Dbxl-derived Neural Progenitors
Dbxl 衍生神经祖细胞嗅觉回路的组装和功能
  • 批准号:
    9229549
  • 财政年份:
    2013
  • 资助金额:
    $ 20.91万
  • 项目类别:
Development of the basal telencephalic limbic system
基础端脑边缘系统的发育
  • 批准号:
    7821751
  • 财政年份:
    2009
  • 资助金额:
    $ 20.91万
  • 项目类别:
Development of the Basal Telencephalic Limbic System
基底端脑边缘系统的发育
  • 批准号:
    8040686
  • 财政年份:
    2006
  • 资助金额:
    $ 20.91万
  • 项目类别:

相似海外基金

Identification of Prospective Predictors of Alcohol Initiation During Early Adolescence
青春期早期饮酒的前瞻性预测因素的鉴定
  • 批准号:
    10823917
  • 财政年份:
    2024
  • 资助金额:
    $ 20.91万
  • 项目类别:
Socio-Emotional Characteristics in Early Childhood and Offending Behaviour in Adolescence
幼儿期的社会情感特征和青春期的犯罪行为
  • 批准号:
    ES/Z502601/1
  • 财政年份:
    2024
  • 资助金额:
    $ 20.91万
  • 项目类别:
    Fellowship
Cognitive and non-cognitive abilities and career development during adolescence and adult development: from the perspective of genetic and environmental structure
青春期和成人发展期间的认知和非认知能力与职业发展:从遗传和环境结构的角度
  • 批准号:
    23K02900
  • 财政年份:
    2023
  • 资助金额:
    $ 20.91万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Reasoning about Spatial Relations and Distributions: Supporting STEM Learning in Early Adolescence
空间关系和分布的推理:支持青春期早期的 STEM 学习
  • 批准号:
    2300937
  • 财政年份:
    2023
  • 资助金额:
    $ 20.91万
  • 项目类别:
    Continuing Grant
Does social motivation in adolescence differentially predict the impact of childhood threat exposure on developing suicidal thoughts and behaviors
青春期的社会动机是否可以差异预测童年威胁暴露对自杀想法和行为的影响
  • 批准号:
    10785373
  • 财政年份:
    2023
  • 资助金额:
    $ 20.91万
  • 项目类别:
Mapping the Neurobiological Risks and Consequences of Alcohol Use in Adolescence and Across the Lifespan
绘制青春期和整个生命周期饮酒的神经生物学风险和后果
  • 批准号:
    10733406
  • 财政年份:
    2023
  • 资助金额:
    $ 20.91万
  • 项目类别:
The Role of Sleep in the Relationships Among Adverse Childhood Experiences, Mental Health Symptoms, and Persistent/Recurrent Pain during Adolescence
睡眠在不良童年经历、心理健康症状和青春期持续/复发性疼痛之间关系中的作用
  • 批准号:
    10676403
  • 财政年份:
    2023
  • 资助金额:
    $ 20.91万
  • 项目类别:
Thalamo-prefrontal circuit maturation during adolescence
丘脑-前额叶回路在青春期成熟
  • 批准号:
    10585031
  • 财政年份:
    2023
  • 资助金额:
    $ 20.91万
  • 项目类别:
Interdisciplinary Perspectives on the Politics of Adolescence and Democracy
青少年政治与民主的跨学科视角
  • 批准号:
    EP/X026825/1
  • 财政年份:
    2023
  • 资助金额:
    $ 20.91万
  • 项目类别:
    Research Grant
An Empirical Study on the Influence of Socioeconomic Status in Adolescence on Exercise Habits in Adulthood
青春期社会经济地位对成年期运动习惯影响的实证研究
  • 批准号:
    23K16734
  • 财政年份:
    2023
  • 资助金额:
    $ 20.91万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了