Development of Advanced C-arm Cone-Beam CT for the Treatment of Liver Cancer

先进C型臂锥束CT治疗肝癌的开发

• 批准号: 8616609
• 负责人: XIAOCHUAN PAN
• 金额: $ 48.39万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8616609
• 关键词: Address; Advanced Development; Algorithms; Anatomy; Asorbicap; Catheters; Clinical; Contrast Media; Data; Development; Dose; Evaluation Studies; Fluoroscopy; Hepatic; Image; Image-Guided Surgery; Imagery; Interruption; Intervention; Kidney; Lead; Lesion; Life; Liver; Liver neoplasms; Lung; Malignant Neoplasms; Malignant neoplasm of liver; Methods; Morphologic artifacts; Nephrotoxic; Noise; Operative Surgical Procedures; Patients; Procedures; Protocols documentation; Radiation; Radiation therapy; Research; Research Design; Rotation; Sampling; Scanning; Sterile coverings; Techniques; Technology; Therapeutic Embolization; Time; Tissues; Work; arm; base; cancer therapy; clinically significant; cone-beam computed tomography; design; detector; feeding; hazard; image reconstruction; imaging modality; improved; innovation; insight; liver visualization; preclinical study; prevent; programs; public health relevance; reconstruction; standard of care; tumor

Abstract/Project Summary The objective of this program is to improve cone-beam computed tomography (CBCT) imaging performed on an interventional C-arm for guiding catheter-directed embolization of liver tumor in particular, and multiple other interventional procedures. The current standard of care for hepatic catheter directed therapy uses an interventional C-arm and injected contrast agent to visualize tumor and its feeding vessels. C-arm CBCT can be used to understand the lesion anatomy, allowing 3D visualization of the tumor and feeding vessels. However, current C-arm CBCT is far from being optimized for the application due to a number of important limitations concerning exam time, radiation dose, image quality, and intrusiveness to workflow. These limitations can be addressed through the development of innovative CBCT scans and optimization-based reconstructions. In the project, we focus on tackling the practical limitations of the C-arm CBCT in image- guided liver-tumor catheter delivery through the development of innovative scans and optimization-based reconstructions, and demonstrating their translational potential to clinical tasks of image-guided liver-tumor treatment. The specific aims of the project include (1) to develop optimization-based reconstruction for improving current C-arm imaging, (2) to develop scans and optimization-based reconstruction for further improving C-arm imaging, and (3) to verify, characterize, and evaluate optimization-based reconstructions. The clinical and technical significances of the project are high, because it can directly impact significantly intervention and treatment of liver-cancer and other forms of cancer, particularly, in the lung and kidney, and because it can lead to the development of advanced C-arm CBCT technology for addressing technical challenges such as sparse-view, truncation, and limited-angular-range problems of extremely high practical merit. The project has a high level of innovation, because it includes numerous creative ideas and methods for enhancing workflow and for reducing contrast volume, radiation dose, and patient discomfort.

摘要/项目摘要 该计划的目标是改进锥束计算机断层扫描(CBCT)成像 一种介入性C臂，用于引导导管导向的肝肿瘤栓塞术，以及多种其他 介入手术。目前肝导管定向治疗的护理标准使用一种 介入性C臂和注射造影剂显示肿瘤及其供血血管。C臂CBCT可以 可用于了解病变解剖结构，从而实现肿瘤和供血血管的3D可视化。 然而，当前的C型臂CBCT远远没有针对应用进行优化，原因是许多重要的 检查时间、辐射剂量、图像质量和对工作流程的侵入性方面的限制。这些 可以通过开发创新的CBCT扫描和基于优化的 重建。在该项目中，我们将重点解决C-ARM CBCT在图像方面的实际限制- 通过创新扫描和基于优化的开发来指导肝肿瘤导管输送 重建，并展示了它们对图像引导的肝肿瘤临床任务的翻译潜力 治疗。该项目的具体目标包括(1)开发基于优化的重建 改进当前的C臂成像，(2)开发扫描和基于优化的重建，以便进一步 改进C臂成像，以及(3)验证、表征和评估基于优化的重建。这个 该项目的临床意义和技术意义都很高，因为它可以直接影响到 干预和治疗肝癌和其他形式的癌症，特别是肺癌和肾癌，以及 因为它可以带动先进的C-ARM CBCT技术的发展，以解决 极高实用性的稀疏视点、截断和有限角度范围问题等挑战 功绩。该项目具有很高的创新水平，因为它包含了许多创造性的想法和方法 增强工作流程，减少对比度、辐射剂量和患者不适。