Characterization of a newly-discovered cell type family in the retina
视网膜中新发现的细胞类型家族的表征
基本信息
- 批准号:8831766
- 负责人:
- 金额:$ 5.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-12-01 至 2017-11-30
- 项目状态:已结题
- 来源:
- 关键词:AddressArchitectureAreaCalciumCell Adhesion MoleculesCell Surface ProteinsCellsCollaborationsDataDendritic CellsDetectionDevelopmentDevelopmental GeneElectron MicroscopyEmployee StrikesEnvironmentFaceFamilyGene ExpressionIndividualInterneuronsLightMapsMolecularMonitorMorphologyMotionMovementNervous System PhysiologyNeuraxisNeuronsNosePatternProcessPropertyRelative (related person)ResolutionRetinaRetinal Ganglion CellsRoleSensorySensory ProcessSeriesStereotypingStimulusStratificationSynapsesTestingTimeTracerVisualVisual AcuityVisual FieldsVisual system structurecell typecombinatorialganglion cellloss of functionmemberneural circuitnovelobject motionparallel computerparallel processingpresynapticpublic health relevancereceptive fieldreconstructionresearch studyresponsetranscription factorvisual information
项目摘要
DESCRIPTION (provided by applicant): Precise connectivity between diverse neuronal subtypes is required for nervous system function. In the retina, progress has been made understanding how individual subtypes of retinal ganglion cells (RGCs) form lamina-restricted circuits with specific functions, like detection of object movement (termed direction selectivity [DS]). Less is known about the way closely related neuronal sets (families) are organized and connected to process related visual information. Recently, I discovered multiple members of a new RGC family, including two previously undescribed RGC subtypes. These cells show striking morphological and molecular similarity to a known DS cell called J-RGCs, but differ in their respective dendritic field areas. I call these new cells the "J-family". Because dendritic field ara correlates strongly with sensory acuity, the J-family may process object motion over a range of spatial resolutions. Here I propose a series of experiments to better understand this novel cell type family, including their relative organization, receptive field properties, and development. I will also test the role of candidate molecules in J-cell circuit formation and function. These studies will reveal fundamental principles in the development of a related neuronal set, and elucidate how similar aspects of sensory processing may be delegated across divergent cell type families in the CNS.
描述(由申请人提供):神经系统功能需要不同神经元亚型之间的精确连接。在视网膜中,人们在了解视网膜神经节细胞(RGC)的各个亚型如何形成具有特定功能的层限制回路方面取得了进展,例如检测物体移动(称为方向选择性[DS])。关于密切相关的神经元集合(家族)的组织和连接方式,以处理相关的视觉信息,我们知之甚少。最近,我发现了一个新的RGC家族的多个成员,包括两个以前未描述的RGC亚型。这些细胞与已知的称为J-RGC的DS细胞显示出惊人的形态和分子相似性,但在各自的树突状区域中不同。我称这些新细胞为“J家族”。由于树突场ara与感觉敏锐度密切相关,J家族可以在一定范围的空间分辨率上处理对象运动。在这里,我提出了一系列的实验,以更好地了解这种新的细胞类型的家庭,包括他们的相对组织,感受野的属性,和发展。我还将测试候选分子在J细胞回路形成和功能中的作用。这些研究将揭示相关神经元组发育的基本原理,并阐明感觉处理的相似方面如何在CNS中的不同细胞类型家族中被委派。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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David Leon Rousso其他文献
David Leon Rousso的其他文献
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{{ truncateString('David Leon Rousso', 18)}}的其他基金
Characterization of a newly-discovered cell type family in the retina
视网膜中新发现的细胞类型家族的表征
- 批准号:
8987424 - 财政年份:2014
- 资助金额:
$ 5.6万 - 项目类别:
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