Maintenance and Improvement of NINDS Infrastructure

NINDS基础设施的维护和改进

• 批准号: 9157600
• 负责人: Alan Koretsky
• 金额: $ 850.34万
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9157600
• 关键词: Animals; Area; Biophysics; Cellular biology; Chief Cell; Chlorine; Clinical; Dendrites; Development; Disease; Ensure; Equipment; Farming environment; Functional Magnetic Resonance Imaging; Goals; High Pressure Liquid Chromatography; Housing; Image; Immunology; Inherited; Institutes; Laboratories; Laboratory Research; Lead; Light Microscope; Location; Magnetic Resonance Imaging; Maintenance; Molecular; Morphogenesis; Myopathy; National Center for Complementary and Alternative Medicine; National Institute of Mental Health; National Institute of Neurological Disorders and Stroke; Neuropharmacology; Neurosciences; Neurosciences Research; Phase; Physiology; Positron-Emission Tomography; Proteomics; Recruitment Activity; Research; Research Infrastructure; Research Support; Resources; Scientist; Stroke; Synapses; System; United States National Institutes of Health; Viral; Water; Wing; Work; animal facility; cost effective; drinking; extracellular; intravital imaging; mass spectrometer; neural circuit; neurosurgery; protein aminoacid sequence; relating to nervous system; structural biology; synaptic function

NATIONAL INSTITUTES OF HEALTH NINDS Facilities Planning / Equipment Bldg 35, GF352-4 The following laboratories and research support areas underwent renovations during FY 2015: 1. Perform the lab renovation for Dr Kevin Briggman, Chief, Circuit Dynamics and Connectivity unit. Location, NIH Campus, Bldg 35. 2. Relocation and activation activities for the Porter Neuroscience Research Center Phase 2, Mixed institute laboratory building, with NINDS as the lead institute. Location, NIH Bethesda Campus, Bldg 35. 3. Perform a renovation to the freezer farm room located in the Porter Neuroscience Research Center that supports multiple ICs. Location, NIH Bethesda Campus, Bldg 35. 4. Perform a renovation to the Autoclaves in B-Wing that supports multiple PIs. Location, NIH Bethesda Campus, Bldg 49. 5. Complete the lab renovation and fit-out for Dr Quan Yuan, Chief, Dendrite Morphogenesis and Plasticity Unit. Location, NIH Bethesda Campus, Bldg 35. 6. Perform a lab renovation and fit-out for Dr Kenton Swartz, Chief, Molecular Physiology & Biophysics Section. Location, NIH Bethesda Campus, Bldg 35. 7. Relocation and activation activities for the F-Wing project, Mixed institute laboratory wing. Laboratory construction includes work for laboratories and offices for two PIs, Dr Dragan Maric Chief, FACS Facility and Dr Dorian McGavern, Chief, Viral Immunology and Intravital Imaging Section and one new NINDS PI recruit. Location, NIH Bethesda Campus, Bldg 10. 8. Complete the lab renovation and fit-out for Dr Lucy Forrest, Chief, Computational Structural Biology Unit. Location, NIH Bethesda Campus, Bldg 35. 9. Perform the lab renovation and fit-out for Dr Wei Lu, Chief, Synapse and Neural Ciruit Unit. Location, NIH Bethesda Campus, Bldg 35. 10. Perform the lab renovation and fit-out for Dr Craig Blackstone, Chief, Cell Biology Section. Location, NIH Bethesda Campus, Bldg 35. 11. Perform a lab renovation and fit-out for Dr David Sibley, Chief, Molecular Neuropharmacology Section. Location, NIH Bethesda Campus, Bldg 35. 12. Renovate the chlorine repressurization animal drinking system for the PNRC Shared Animal Facility. Location, NIH Bethesda Campus, Bldg 35. 13. Renovate the procurement and administrative offices. Location, NIH Bethesda Campus, Bldg 35. 14. Perform the lab renovation for Dr Ami Mankodi, Chief, Hereditary Muscle Diseases Unit. Location, NIH Bethesda Campus, Bldg 35. 15. Perform the renovation to the office for Dr Bibiana Bielekova, Chief, Neuroimmunological Diseases Unit. Location, NIH Bethesda Campus, Bldg 10. 16. Complete the lab renovation for Dr Alex Chesler, NCCAM, as part of a collaborative and shared space arrangement. Location, NIH Bethesda Campus, Bldg 35. 17. Perform a renovation to add two offices for Dr John Hallenbeck, Chief, Stroke Branch. Location, NIH Bethesda Campus, Bldg 10. 18. Perform a renovation to install a 17T MRI Magnet to support NINDS Intramural PIs. Location, NIH Bethesda Campus, Bldg 35. 19. Initiate a renovation plan for the 11.7T MRI Magnet facility that supports NIH Intramural PIs. Location, NIH Bethesda Campus, Bldg 10. 20. Perform a renovation to the laboratory space that houses Mass Spectrometers for Dr Joseph Steiner, Chief, Neurotherapeutic Development Unit. Location, NIH Bethesda Campus, Bldg 10. 21. Perform a renovation to the office suite for Laurie Arrants, Chief, NINDS Office for Tech Transfer. Location, NIH Bethesda Campus, Bldg 31. The following pieces of major shared equipment were purchased to support a large number of PIs: 1. Zeiss LSM 880 confocal microscope for the Light Imaging Facility, Synaptic Functions Section, and Synapse and Neural Circuit Unit. 2. Waters Breeze 2 HPLC System with Spectrophotometer for the Molecular Physiology & Biophysics Section 3. Q Exactive HF Standard Mass Spectrometer for the Clinical Proteomics Unit 4. Leica TCS SP8 Mass Spectrometer for the Viral Immunology & Intravital Imaging Unit 5. LC-MS system for sequencing for the Peptide Sequencing Facility 6. XFe96 Extracellular Flux Analyzer for the Clinical Neurosurgery Unit 7. 3T & 4T MRI scanner upgrades for the shared NIMH/NINDS fMRI Facility 8. PET CT upgrade for the Clinical Center

国立卫生研究院 NINDS设施规划/设备 35号楼，GF 352 -4 以下实验室和研究支持领域在2015财年进行了翻新： 1. 为电路动力学和连接部主任Kevin Briggman博士进行实验室改造。地点，NIH校园，35号楼。 2. 波特神经科学研究中心第2阶段的搬迁和激活活动，混合研究所实验室大楼，NINDS作为牵头研究所。地点：NIH Bethesda Campus，Bldg 35。 3. 对位于Porter神经科学研究中心的冷冻室进行改造，该冷冻室支持多个IC。 地点：NIH Bethesda Campus，Bldg 35。 4. 对B翼的高压灭菌器进行改造，以支持多个PI。 地点，NIH Bethesda Campus，Bldg 49。 5. 为袁泉博士（枝晶形态发生和可塑性研究室主任）完成实验室的装修。 地点：NIH Bethesda Campus，Bldg 35。 6. 为分子生理学和生物物理学科科长Dr. Swartz进行实验室翻新和装修。 地点：NIH Bethesda Campus，Bldg 35。 7. F-Wing项目的搬迁和激活活动，混合研究所实验室翼。实验室建设包括两名PI的实验室和办公室工作，Dragan Maric博士，FACS设施主任和Dorian McGavern博士，病毒免疫学和活体成像科科长，以及一名新的NINDS PI招聘。地点：NIH Bethesda Campus，Bldg 10。 8. 完成实验室装修和露西福雷斯特博士，首席，计算结构生物学单位。地点：NIH Bethesda Campus，Bldg 35。 9. 为神经网络和神经回路部主任卢伟博士进行实验室改造和装修。地点：NIH Bethesda Campus，Bldg 35。 10. 为细胞生物学科科长克雷格博士黑石进行实验室改造和装修。 地点：NIH Bethesda Campus，Bldg 35。 11. 为分子神经药理学科科长大卫西布利博士进行实验室翻新和装修。 地点：NIH Bethesda Campus，Bldg 35。 12. 更新PNRC共享动物设施的氯加压动物饮水系统。 地点：NIH Bethesda Campus，Bldg 35。 13. 更新采购和行政办公室。 地点：NIH Bethesda Campus，Bldg 35。 14. 为遗传性肌肉疾病科科长Ami Mankodi博士进行实验室改造。 地点：NIH Bethesda Campus，Bldg 35。 15. 为神经免疫疾病科科长Bibiana Bielekova博士的办公室进行装修。 地点：NIH Bethesda Campus，Bldg 10。 16. 完成亚历克斯·切斯勒博士，NCCAM的实验室改造，作为合作和共享空间安排的一部分。 地点：NIH Bethesda Campus，Bldg 35。 17. 进行翻修，为中风分支主任John Hallenbeck博士增加两个办公室。 地点：NIH Bethesda Campus，Bldg 10。 18. 进行改造，安装17 T MRI磁体，以支持NINDS Intramural PI。 地点：NIH Bethesda Campus，Bldg 35。 19. 启动支持NIH校内PI的11.7T MRI磁体设施的改造计划。 地点：NIH Bethesda Campus，Bldg 10。 20. 为神经治疗开发部门负责人约瑟夫·施泰纳博士对实验室空间进行改造，该空间装有质谱仪。 地点：NIH Bethesda Campus，Bldg 10。 21. 为NINDS技术转移办公室主任劳里·阿兰茨进行办公室装修。 地点：NIH Bethesda Campus，Bldg 31。 购买了以下主要共用设备，以支持大量的专业人员： 1. 蔡司LSM 880共聚焦显微镜用于光成像设备、突触功能部分以及突触和神经回路单元。 2. 配备分光光度计的沃茨Breeze 2 HPLC系统，用于分子生理学和生物物理学部分 3. 用于临床蛋白质组学单元的Q Exactive HF标准质谱仪 4. 用于病毒免疫学和活体成像单元的Leica TCS SP 8质谱仪 5. 用于肽测序设施测序的LC-MS系统 6. XFe 96细胞外液流量分析仪用于临床神经外科 7. NIMH/NINDS共享fMRI设施的3 T和4 T MRI扫描仪升级 8. 临床中心PET CT升级