Maintenance and Improvement of NINDS Infrastructure

NINDS基础设施的维护和改进

• 批准号: 9157600
• 负责人: Alan Koretsky
• 金额: $ 850.34万
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9157600
• 关键词: Animals; Area; Biophysics; Cellular biology; Chief Cell; Chlorine; Clinical; Dendrites; Development; Disease; Ensure; Equipment; Farming environment; Functional Magnetic Resonance Imaging; Goals; High Pressure Liquid Chromatography; Housing; Image; Immunology; Inherited; Institutes; Laboratories; Laboratory Research; Lead; Light Microscope; Location; Magnetic Resonance Imaging; Maintenance; Molecular; Morphogenesis; Myopathy; National Center for Complementary and Alternative Medicine; National Institute of Mental Health; National Institute of Neurological Disorders and Stroke; Neuropharmacology; Neurosciences; Neurosciences Research; Phase; Physiology; Positron-Emission Tomography; Proteomics; Recruitment Activity; Research; Research Infrastructure; Research Support; Resources; Scientist; Stroke; Synapses; System; United States National Institutes of Health; Viral; Water; Wing; Work; animal facility; cost effective; drinking; extracellular; intravital imaging; mass spectrometer; neural circuit; neurosurgery; protein aminoacid sequence; relating to nervous system; structural biology; synaptic function

NATIONAL INSTITUTES OF HEALTH NINDS Facilities Planning / Equipment Bldg 35, GF352-4 The following laboratories and research support areas underwent renovations during FY 2015: 1. Perform the lab renovation for Dr Kevin Briggman, Chief, Circuit Dynamics and Connectivity unit. Location, NIH Campus, Bldg 35. 2. Relocation and activation activities for the Porter Neuroscience Research Center Phase 2, Mixed institute laboratory building, with NINDS as the lead institute. Location, NIH Bethesda Campus, Bldg 35. 3. Perform a renovation to the freezer farm room located in the Porter Neuroscience Research Center that supports multiple ICs. Location, NIH Bethesda Campus, Bldg 35. 4. Perform a renovation to the Autoclaves in B-Wing that supports multiple PIs. Location, NIH Bethesda Campus, Bldg 49. 5. Complete the lab renovation and fit-out for Dr Quan Yuan, Chief, Dendrite Morphogenesis and Plasticity Unit. Location, NIH Bethesda Campus, Bldg 35. 6. Perform a lab renovation and fit-out for Dr Kenton Swartz, Chief, Molecular Physiology & Biophysics Section. Location, NIH Bethesda Campus, Bldg 35. 7. Relocation and activation activities for the F-Wing project, Mixed institute laboratory wing. Laboratory construction includes work for laboratories and offices for two PIs, Dr Dragan Maric Chief, FACS Facility and Dr Dorian McGavern, Chief, Viral Immunology and Intravital Imaging Section and one new NINDS PI recruit. Location, NIH Bethesda Campus, Bldg 10. 8. Complete the lab renovation and fit-out for Dr Lucy Forrest, Chief, Computational Structural Biology Unit. Location, NIH Bethesda Campus, Bldg 35. 9. Perform the lab renovation and fit-out for Dr Wei Lu, Chief, Synapse and Neural Ciruit Unit. Location, NIH Bethesda Campus, Bldg 35. 10. Perform the lab renovation and fit-out for Dr Craig Blackstone, Chief, Cell Biology Section. Location, NIH Bethesda Campus, Bldg 35. 11. Perform a lab renovation and fit-out for Dr David Sibley, Chief, Molecular Neuropharmacology Section. Location, NIH Bethesda Campus, Bldg 35. 12. Renovate the chlorine repressurization animal drinking system for the PNRC Shared Animal Facility. Location, NIH Bethesda Campus, Bldg 35. 13. Renovate the procurement and administrative offices. Location, NIH Bethesda Campus, Bldg 35. 14. Perform the lab renovation for Dr Ami Mankodi, Chief, Hereditary Muscle Diseases Unit. Location, NIH Bethesda Campus, Bldg 35. 15. Perform the renovation to the office for Dr Bibiana Bielekova, Chief, Neuroimmunological Diseases Unit. Location, NIH Bethesda Campus, Bldg 10. 16. Complete the lab renovation for Dr Alex Chesler, NCCAM, as part of a collaborative and shared space arrangement. Location, NIH Bethesda Campus, Bldg 35. 17. Perform a renovation to add two offices for Dr John Hallenbeck, Chief, Stroke Branch. Location, NIH Bethesda Campus, Bldg 10. 18. Perform a renovation to install a 17T MRI Magnet to support NINDS Intramural PIs. Location, NIH Bethesda Campus, Bldg 35. 19. Initiate a renovation plan for the 11.7T MRI Magnet facility that supports NIH Intramural PIs. Location, NIH Bethesda Campus, Bldg 10. 20. Perform a renovation to the laboratory space that houses Mass Spectrometers for Dr Joseph Steiner, Chief, Neurotherapeutic Development Unit. Location, NIH Bethesda Campus, Bldg 10. 21. Perform a renovation to the office suite for Laurie Arrants, Chief, NINDS Office for Tech Transfer. Location, NIH Bethesda Campus, Bldg 31. The following pieces of major shared equipment were purchased to support a large number of PIs: 1. Zeiss LSM 880 confocal microscope for the Light Imaging Facility, Synaptic Functions Section, and Synapse and Neural Circuit Unit. 2. Waters Breeze 2 HPLC System with Spectrophotometer for the Molecular Physiology & Biophysics Section 3. Q Exactive HF Standard Mass Spectrometer for the Clinical Proteomics Unit 4. Leica TCS SP8 Mass Spectrometer for the Viral Immunology & Intravital Imaging Unit 5. LC-MS system for sequencing for the Peptide Sequencing Facility 6. XFe96 Extracellular Flux Analyzer for the Clinical Neurosurgery Unit 7. 3T & 4T MRI scanner upgrades for the shared NIMH/NINDS fMRI Facility 8. PET CT upgrade for the Clinical Center

国家卫生研究院 NINDS 设施规划/设备 35号楼，GF352-4 以下实验室和研究支持区域在 2015 财年进行了翻修： 1. 为电路动力学和连接部门主管 Kevin Briggman 博士进行实验室改造。地点，NIH 校区，35 号楼。 2. 波特神经科学研究中心二期混合研究所实验室大楼的搬迁和启用活动，以 NINDS 为牵头机构。地点，NIH 贝塞斯达校区，35 号楼。 3. 对波特神经科学研究中心支持多种 IC 的冷冻农场进行改造。 地点，NIH 贝塞斯达校区，35 号楼。 4. 对 B-Wing 中支持多个 PI 的高压灭菌器进行改造。 地点，NIH 贝塞斯达校区，49 号楼。 5. 完成枝晶形态发生与可塑性研究组组长袁泉博士的实验室改造和装修。 地点，NIH 贝塞斯达校区，35 号楼。 6. 为分子生理学和生物物理学科科长 Kenton Swartz 博士进行实验室改造和装修。 地点，NIH 贝塞斯达校区，35 号楼。 7. 混合研究所实验室翼 F-Wing 项目的搬迁和启动活动。实验室建设包括两名 PI 的实验室和办公室工作，即 FACS 设施主任 Dragan Maric 博士和病毒免疫学和活体成像科主任 Dorian McGavern 博士以及一名新聘的 NINDS PI。地点，NIH 贝塞斯达校区，10 号楼。 8. 完成计算结构生物学组组长 Lucy Forrest 博士的实验室改造和装修。地点，NIH 贝塞斯达校区，35 号楼。 9. 为突触和神经回路组组长卢伟博士进行实验室改造和装修。地点，NIH 贝塞斯达校区，35 号楼。 10. 为细胞生物学科科长 Craig Blackstone 博士进行实验室改造和装修。 地点，NIH 贝塞斯达校区，35 号楼。 11. 为分子神经药理学科科长 David Sibley 博士进行实验室改造和装修。 地点，NIH 贝塞斯达校区，35 号楼。 12. 改造 PNRC 共享动物设施的氯加压动物饮水系统。 地点，NIH 贝塞斯达校区，35 号楼。 13. 装修采购和行政办公室。 地点，NIH 贝塞斯达校区，35 号楼。 14. 为遗传性肌肉疾病科主任 Ami Mankodi 博士进行实验室改造。 地点，NIH 贝塞斯达校区，35 号楼。 15. 对神经免疫疾病科主任 Bibiana Bielekova 博士的办公室进行翻修。 地点，NIH 贝塞斯达校区，10 号楼。 16. 完成 NCCAM Alex Chesler 博士的实验室改造，作为协作和共享空间安排的一部分。 地点，NIH 贝塞斯达校区，35 号楼。 17. 进行翻修，为中风科主任 John Hallenbeck 医生增设两间办公室。 地点，NIH 贝塞斯达校区，10 号楼。 18. 进行翻新，安装 17T MRI 磁铁，以支持 NINDS 壁内 PI。 地点，NIH 贝塞斯达校区，35 号楼。 19. 启动支持 NIH 校内 PI 的 11.7T MRI 磁体设施改造计划。 地点，NIH 贝塞斯达校区，10 号楼。 20. 对神经治疗开发部门负责人 Joseph Steiner 博士配备质谱仪的实验室空间进行翻修。 地点，NIH 贝塞斯达校区，10 号楼。 21. 对 NINDS 技术转让办公室主任 Laurie Arrants 的办公套件进行翻修。 地点，NIH 贝塞斯达校区，31 号楼。 为了支持大量PI，购买了以下主要共享设备： 1. 用于光学成像设备、突触功能部分以及突触和神经回路单元的 Zeiss LSM 880 共焦显微镜。 2. 用于分子生理学和生物物理学部分的带分光光度计的 Waters Breeze 2 HPLC 系统 3. 用于临床蛋白质组学单元的 Q Exactive HF 标准质谱仪 4. 用于病毒免疫学和活体成像装置的 Leica TCS SP8 质谱仪 5. 用于肽测序设施测序的 LC-MS 系统 6. 用于临床神经外科的XFe96细胞外通量分析仪 7. 共享 NIMH/NINDS fMRI 设施的 3T 和 4T MRI 扫描仪升级 8. 临床中心PET CT升级