Gulf Longitudinal Follow-up (GuLF) Study

海湾纵向随访（GuLF）研究

• 批准号: 9143506
• 负责人: Dale P Sandler
• 金额: $ 54.24万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9143506
• 关键词: Area; Behavioral; Biological; Biological Markers; Burn injury; Cardiovascular system; Chemicals; Clinic; Clinical; Collection; DNA Damage; Data; Development; Disasters; Economics; Environment; Environmental and Occupational Exposure; Epigenetic Process; Exposure to; Gene Expression; Health; Heat Stress Disorders; Hepatic; Hormones; Human; Immune; Immunologics; International; Interview; Journals; Kidney; Lead; Life Style; Longitudinal Studies; Malignant Neoplasms; Mental Health; Mental Health Services; Mexico; Monitor; National Institute of Environmental Health Sciences; Nervous System Physiology; Neurologic; Oils; Outcome; Participant; Peer Review; Persons; Petroleum; Physiological; Population; Population Study; Preparation; Publications; Pulmonary function tests; Questionnaires; Renal function; Reporting; Research; Research Personnel; Resources; Safety; Saliva; Sampling; Scientist; Statistical Models; Stress; Subgroup; Substance abuse problem; Testing; Toxin; Training; United States National Institutes of Health; Work; Writing; cohort; design; experience; follow-up; health care service utilization; interest; meetings; member; reproductive; respiratory; traumatic event

NIEHS is leading a National Institutes of Health (NIH) long term study looking at the potential health effects of the oil spill in various responder populations. During FY 2015, the GuLF STUDY (Gulf Long-term Follow-Up Study) actively conducted the follow-up interviews. Additionally, NIEHS investigators are in the midst of inviting 6,200 English-speaking cohort members from within 60 miles of clinics in New Orleans, LA or Mobile, AL to take part in clinical examinations for the Biomedical Surveillance Sub-Cohort, in hopes of completing exams with 3,500 to 4,000 participants. Participants undergo comprehensive lung function testing and be asked to complete a battery of behavioral and physiological tests to assess neurological function. Biological samples will be collected to assess immune, renal, and kidney function. Smaller clinical sub-studies, such as assessing temporal changes in stress hormones through collection of repeat saliva samples, are also included. Finally, participants complete a comprehensive clinical mental health assessment which includes questionnaire modules to assess traumatic events and substance abuse as well as questions designed to assess mental health services utilization by participants. In the meantime, NIEHS investigators are working to evaluate all of the available environmental and occupational exposure monitoring data in order to more completely characterize exposures in the study population. Ongoing statistical modeling will lead to the development of cleanup-task specific exposure matrices that will allow assignment of exposure estimates for volatile compounds and other exposures related to oil spill cleanup. Approaches and preliminary results from exposure characterization efforts were presented at national and international meetings. Cleaning and analysis of the baseline data has begun and we will be reporting findings at scientific meetings and writing up the results for publication in peer-reviewed journals.

NIEHS正在领导一项美国国立卫生研究院（NIH）的长期研究，研究石油泄漏对不同响应人群的潜在健康影响。在2015财年，GuLF STUDY （GuLF Long-term Follow-Up STUDY）积极开展了随访访谈。此外，NIEHS的调查人员正在邀请6200名讲英语的队列成员，他们来自洛杉矶新奥尔良或美国莫比尔60英里范围内的诊所，参加生物医学监测亚队列的临床检查，希望能完成3500至4000名参与者的检查。参与者接受全面的肺功能测试，并被要求完成一系列行为和生理测试，以评估神经功能。收集生物样本以评估免疫、肾脏和肾脏功能。较小的临床亚研究，如通过收集重复唾液样本来评估压力激素的时间变化，也包括在内。最后，参与者完成一项全面的临床心理健康评估，其中包括评估创伤性事件和药物滥用的问卷模块，以及评估参与者利用心理健康服务情况的问题。