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英文摘要
 DESCRIPTION (provided by applicant): The goal of this project is to test the efficacy of a silent speech interface (SSI) as an alternative mode of oral communication for persons who are unable to use their voice (e.g., after laryngectomy, surgical removal of larynx due to the treatment of cancer). We have recently developed a real-time, interactive SSI based on a commercial electromagnetic articulograph. The SSI converts tongue and lip movement to text, and then plays back corresponding synthesized speech sounds with natural sounding voice in real-time. The SSI has potential to restore the patient's voice by identifying the patient's voice characteristics before laryngectomy. Preliminary tests on healthy participants demonstrated the feasibility of the SSI. In this project, we further evaluate the system by studying 15 participants after laryngectomy and 15 age- and gender-matched healthy controls. If successful, the SSI has the potential to transform clinical practice for speech-language pathologists other related health care professionals. The proposed research will enhance human health by making an impact on individuals after laryngectomy and potentially to a broad range of other speech and voice disorders.
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Striatal ensemble plasticity in alcohol use disorder
Development of dual inhibitors targeting the viral main protease and the host cathepsin L as SARS-CoV-2 antivirals
High-Resolution Spatial MIST Technology for Functional Proteomic Study of Neuroinflammation in Alzheimer's Disease
Repurposing of Maraviroc for the treatment of neuropathic pain
国内基金
海外基金
补阳还五汤通过AGE-RAGE通路调控脓毒症免疫失衡的机制与转化研究
靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
  • 批准号:
    JCZRQN202500010
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2025
  • 负责人:
  • 依托单位:
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
  • 批准号:
    2025JJ70209
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2025
  • 负责人:
    雷芬芳
  • 依托单位:
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
  • 批准号:
    --
  • 项目类别:
    面上项目
  • 资助金额:
    --
  • 批准年份:
    2024
  • 负责人:
    万荣
  • 依托单位: