Training Program in Diabetes Research

描述(由申请人提供)： 这项申请是对最先进的糖尿病研究中的儿科内分泌学研究员的培训的更新申请。该培训计划旨在为芭芭拉·戴维斯中心(BDC)和科罗拉多大学医学院(UCSOM)提供糖尿病研究方面的多学科培训。建议的理由是：1)国家严重缺乏儿科内分泌学家，特别是那些在糖尿病研究方面训练有素和经验丰富的人。2)糖尿病是儿科人口中日益严重的医疗问题，从个人和健康经济学的角度来看，对未来造成毁灭性的后果。3)当前糖尿病调查的快速发展要求更多训练有素的高技能内科科学家，在儿科1型和2型糖尿病方面开展相关、高质量的基础和临床转化研究，将糖尿病研究的进展带到临床舞台上。芭芭拉·戴维斯中心在年轻研究人员的研究培训方面有着广泛和成熟的记录。BDC和UCSOM在1型糖尿病的免疫生物学、遗传学和分子生物学以及2型糖尿病的异常病理生理学方面拥有完善的研究网络。这一经验丰富的导师网络非常适合将下一代年轻的儿科内分泌学家培养成独立的糖尿病调查人员。芭芭拉·戴维斯中心的研究重点领域包括胰岛细胞生理学、遗传学、分子生物学、移植免疫学、1型糖尿病的自身免疫、预测和预防，以及1型和2型糖尿病的流行病学、预防和治疗。这些领域的研究是迫切需要的，已被确定为对国家公共健康至关重要，以应对糖尿病在美国的流行。这一应用得到了NIH支持的糖尿病和内分泌学研究中心、成熟的NIH支持的儿科和成人临床转化研究中心、临床营养研究单位、NIH支持的K30临床科学家课程奖以及公共卫生理学硕士项目的加强。这项申请得到了儿科、内科、预防医学部和丹佛儿童医院(TCH)的支持。在我们培训计划的最初四年中，我们展示了我们有能力通过临床科学计划提供关于人类研究的统计学、流行病学、研究方法、伦理学和监管、医学写作、生物化学、药物动力学和分子生物学的强大教学课程，以及通过人类遗传学计划提供人类医学遗传学和分子遗传学，包括基因组学、蛋白质组学和代谢组学。这一教学计划与BDC和UCSOM强大的指导教师队伍相结合，已经并将继续使我们能够提供年轻的儿科内分泌学家发展成为独立研究人员所需的培训，能够在独立研究资金方面具有竞争力。我们的毕业生成功地在学术中心获得了NIH和JDRF个人导师奖和教师职位，我们能够吸引明确致力于学术研究事业的优秀学员，这表明了BDC在糖尿病研究领域培训儿科内分泌学家方面的实力。UCSOM内支持该计划的项目包括免疫耐受网络、自身免疫预防中心和TCH研究基金会。

DESCRIPTION (provided by applicant): This application is a renewal application for the training of pediatric endocrinology fellows in state of the art diabetes research. This training program is designed to provide multidisciplinary training in diabetes research at The Barbara Davis Center (BDC) and The University of Colorado School of Medicine (UCSOM). The proposal's rationale is: 1) there is a critical shortage of pediatric endocrinologists in the country, particularly those trained and experienced in diabetes research 2) Diabetes is an increasingly significant healthcare problem in the pediatric population with devastating consequences from a personal and health economic point of view into the future 3) Current rapid advances in diabetes investigation calls for an increased pool of highly skilled physician scientists trained in clinical, biochemical, epidemiological, and behavioral research to carry out relevant, high quality basic and clinical translational research in pediatric type 1 and type 2 diabetes to bring advances in diabetes research to the clinical arena. The Barbara Davis Center has an extensive and a proven record in research training of young investigators. The BDC and UCSOM have a well established network of investigators working in the immunobiology, genetics, and molecular biology of type 1 diabetes, as well as the abnormal pathophysiology of type 2 diabetes. This network of experienced mentors is ideally suited to develop the next generation of young pediatric endocrinologists into independent diabetes investigators. Areas of research focus within The Barbara Davis Center include islet cell physiology, genetics, molecular biology, transplant immunology, and the autoimmunity, prediction and prevention of type 1 diabetes, as well as the epidemiology, prevention and treatment of type 1 and type 2 diabetes. These areas of research are urgently needed and have been identified as important to the national public health to address the epidemic of diabetes in the U.S. This application is enhanced by the NIH supported Diabetes and Endocrinology Research Center, well established, NIH supported Pediatric and Adult Clinical Translational Research Centers, and a Clinical Nutrition Research Unit, an NIH supported K30 Clinical Scientist Curriculum Award, as well as a strong Masters of Science in Public Health Program. This application has the support of the Departments of Pediatrics, Medicine, Preventive Medicine and The Children's Hospital of Denver (TCH). In the initial four years of our Training Program we have shown our ability to provide strong didactic coursework in statistics, epidemiology, research methods, ethics and regulation of human research, medical writing, biochemistry, pharmacokinetics and molecular biology through the Program in Clinical Science, as well as human medical genetics and molecular genetics, including genomics, proteomics, and metabolomics through the Program in Human Genetics. This didactic program combined with the strong mentoring faculty at the BDC and UCSOM has and will continue to allow us to provide the training young pediatric endocrinologists require to develop into independent investigators, capable of being competitive for independent research funding. The success of our graduates to secure NIH and JDRF individual mentored awards and faculty positions in academic centers, and our ability to attract excellent trainees with a clear commitment to academic research careers indicates the strength of the BDC in training pediatric endocrinologists in diabetes research. Programs within UCSOM which will be supportive of the program include The Immune Tolerance Network, the Autoimmune Prevention Center and TCH Research Foundation.