Training Program in Diabetes Research

描述(由申请人提供)： 这项申请是儿科内分泌学研究员和初级儿科内分泌学教员培训的联合申请的一部分。这一培训计划旨在为芭芭拉·戴维斯中心(BDC)和科罗拉多大学健康科学中心(UCHSC)提供糖尿病研究方面的多学科培训。这项建议的基本原理是：1)国家严重缺乏儿科内分泌学家，特别是那些在糖尿病研究方面受过培训和有经验的人。2)糖尿病是儿科人口中日益严重的医疗问题，从个人和健康经济角度来看，未来会产生毁灭性的后果。3)当前糖尿病研究的快速发展要求更多受过临床、生化、流行病学和行为研究培训的内科科学家进行儿科1型和2型糖尿病的翻译研究，将糖尿病研究的进展带到临床领域。芭芭拉·戴维斯中心在年轻研究人员的研究培训方面拥有广泛和可靠的记录。BDC和UCHSC拥有完善的研究网络，研究1型糖尿病的免疫生物学、遗传学和分子生物学，以及2型糖尿病的异常病理生理学。这一经验丰富的导师网络非常适合将下一代年轻的儿科内分泌学家培养成独立的糖尿病调查人员。芭芭拉·戴维斯中心的研究重点领域包括胰岛细胞生理学、遗传学、分子生物学、移植免疫学、1型糖尿病的自身免疫、预测和预防，以及1型和2型糖尿病的流行病学、预防和治疗。这一应用程序得到了NIH支持的糖尿病和内分泌学研究中心、成熟的NIH支持的儿科和成人临床研究中心、临床营养研究单位、NIH支持的K30临床研究课程奖以及强大的公共卫生科学硕士项目的支持。这项申请得到了儿科、内科、预防医学部和丹佛儿童医院的支持。通过临床科学课程提供统计学、流行病学、研究方法、伦理学和人类研究的监管、医学写作、生物化学、药代动力学和分子生物学以及人类医学遗传学和分子遗传学的强大教学课程的能力，以及BDC和UCHSC强大的指导教师队伍，将使我们能够通过培训和发展成为独立的研究人员，为年轻的儿科内分泌学家提供持续的培训和发展，使他们能够在独立的研究资金和研究活动中具有竞争力。UCHSC内支持这一计划的其他计划包括人类遗传学计划、免疫耐受网络和自身免疫预防中心。

DESCRIPTION (provided by applicant): This application is part of a combined application for training of pediatric endocrinology fellows and junior pediatric endocrinology faculty. This training program is designed to provide multidisciplinary training in diabetes research at The Barbara Davis Center (BDC) and The University of Colorado Health Sciences Center (UCHSC).This proposal's rationale is: 1) there is a critical shortage of pediatric endocrinologists in the country, particularly those trained and experienced in diabetes research 2) Diabetes is an increasingly significant healthcare problem in the pediatric population with devastating consequences from a personal and health economic point of view into the future. 3) Current rapid advances in diabetes investigation calls for an increased pool of physician scientists trained in clinical, biochemical, epidemiological, and behavioral research to carry out translation research in pediatric type 1 and type 2 diabetes to bring advances in diabetes research to the clinical arena. The Barbara Davis Center has extensive and a proven record in research training of young investigators. The BDC and UCHSC have a well established network of investigators working in the immunobiology, genetics, and molecular biology of type 1 diabetes, as well as the abnormal pathophysiology of type 2 diabetes. This network of experienced mentors is ideally suited to develop the next generation of young pediatric endocrinologists into independent diabetes investigators. Areas of research focus within The Barbara Davis Center include islet cell physiology, genetics, molecular biology, transplant immunology, and the autoimmunity, prediction and prevention of type 1 diabetes, and the epidemiology, prevention and treatment of type 1 and type 2 diabetes. This application is enhanced by the NIH supported Diabetes and Endocrinology Research Center, well established, NIH supported Pediatric and Adult Clinical Research Centers, and a Clinical Nutrition Research Unit, an NIH supported K30 Clinical Research Curriculum Award, as well as a strong Masters of Science in Public Health Program. This application has the support of the Departments of Pediatrics, Medicine, Preventive Medicine and The Children's Hospital of Denver. The ability to provide strong didactic coursework in statistics, epidemiology, research methods, ethics and regulation of human research, medical writing, biochemistry, pharmacokinetics and molecular biology, as well as human medical genetics and molecular genetics through the Program in Clinical Science, combined with a strong mentoring faculty at the BDC and UCHSC will allow us to provide the continuous training and development of young pediatric endocrinologists through their training and development into independent investigators, capable of being competitive for independent research funding and research activity. Other programs within UCHSC which will be supportive of this program include the Program in Human Genetics, The Immune Tolerance Network and the Autoimmune Prevention Center.