Research Core

摘要 妇幼医院是一家重要的地区性医院，在临床和 翻译研究。妇婴医院管理局认识到，除了临床 卓越，需要致力于基础科学和翻译科学，以加强医院的研究 进取号。Kilguss研究所是用机构承诺、慈善事业提供的资金建立的 以及卫生资源服务管理局奖。科布雷在过去10年的支持允许 显著加强了Kilguss研究所的研究，重点是发育生物学 和生殖疾病。研究核心带来了当代成像，分子生物学，组织学， 流式细胞术、细胞分类和实时基因表达为目标研究人员提供了以前在很大程度上 临床环境。在第一阶段和第二阶段取得成功的基础上，科布雷第三阶段的目标是 完成国家认可的妇婴围产期生物学中心的建立 医院，并在五年内过渡到一个自给自足、可持续发展的中心。研究核心将 与试点项目和行政核心合作，朝着这一目标迈进。在第三阶段， Research Core将在Kilguss研究所开发一个可持续设施，将提供先进的 为克尔古斯围产期生物学中心的研究人员提供成像和分子生物学能力 研究所和外部用户。 我们提出以下相互关联的具体目标，以实现我们的目标： 具体目标1.提供尖端技术和培训，促进我们的创新研究 用户。我们将发展和升级我们的专业显微镜设施，以巩固我们的优势，并提供 新的成像模式。 具体目标2.通过围产期生物学试点计划和提供新的、 罗德岛生物医学社区目前无法获得的按需技术。我们会 与其他创意机构密切合作，促进资源的交叉利用，并鼓励外部 用户。 具体目标3.实行按服务收费的结构，为核心创造收入，与 强大的机构承诺和捐赠支持，将导致到第5年建立一个自给自足的中心。

ABSTRACT Women & Infants Hospital is an important regional hospital with established excellence in clinical and translational research. Women & Infants Hospital Administration recognized that in addition to clinical excellence, a commitment to basic and translational science was required to enhance the Hospital’s research enterprise. The Kilguss Research Institute was built with funding from Institutional commitments, philanthropy and a Health Resources Services Administration award. The COBRE support for the last 10 years allowed remarkable enhancement of research in the Kilguss Research Institute, with a focus on developmental biology and reproductive diseases. The Research Core brought contemporary imaging, molecular biology, histology, flow cytometry, cell sorting, and real-time gene expression to Target Investigators in a previously largely clinical environment. Based on the success of Phase I & Phase II, the goals of this COBRE Phase III are to complete the establishment of a nationally recognized Center for Perinatal Biology at Women & Infants Hospital, and to transition to a self-supported, sustainable Center in five years. The Research Core will cooperate with the Pilot Projects and Administrative Core to advance towards this target. During Phase III, the Research Core will develop a sustainable facility at the Kilguss Research Institute that will provide advanced imaging and molecular biology capabilities to researchers at the Center for Perinatal Biology, the Kilguss Research Institute, and outside users. We propose the following interrelated specific aims to achieve our goals: Specific Aim 1. Provide cutting edge technologies and training to promote innovative research amongst our users. We will develop and upgrade our specialized microscope facility, to build on our strengths and provide new imaging modalities. Specific Aim 2. Grow our user base by means of the Pilot program in Perinatal Biology and by providing new, in-demand technologies that are not currently available to the Rhode Island biomedical community. We will collaborate closely with other IDeA facilities to promote cross -utilization of resources and encourage outside users. Specific Aim 3. Implement a fee-for-service structure to generate income for the Core which, together with a strong Institutional commitment and endowment support, will lead to a self-sustaining Center by year 5.