Bloomington Drosophila Stock Center at Indiana University

印第安纳大学布卢明顿果蝇库存中心

• 批准号: 8742627
• 负责人: KEVIN R COOK
• 金额: $ 68.78万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8742627
• 关键词: Accounting; Animal Model; Behavior; Biological Models; Biological Process; Cells; Cellular biology; Characteristics; Collection; Communities; Complex; Consultations; Country; Data; Databases; Development; Discipline; Disease; Drosophila genus; Drosophila melanogaster; Ecology; Equilibrium; Eukaryota; Evolution; Fees; Funding; Future; Genes; Genetic; Genetic Transcription; Genome; Genotype; Goals; Grant; Health; Human; Income; Indiana; Individual; Information Resources; Insecta; Institutes; International; Investigation; Investments; Laboratories; Life; Link; Maintenance; Maps; Methodology; Modeling; Molecular; Mutation; N.I.H. Research Support; Neurobiology; Organism; Phenotype; Physiology; Population Biology; Principal Investigator; Recovery; Research; Research Personnel; Research Project Grants; Resource Development; Resources; Role; Sampling; Scientist; Services; Shipping; Ships; Source; Technology; Tissues; United States National Institutes of Health; Universities; Work; base; cost; disease phenotype; drug discovery; fly; functional genomics; genetic strain; genetic technology; genome sequencing; human disease; improved; medical specialties; meetings; mutant; operation; programs; public health relevance; repository; success; tool; trend; web site

DESCRIPTION (provided by applicant): The Bloomington Drosophila Stock Center (BDSC) supports a large, worldwide community of scientists using the insect Drosophila melanogaster as a model organism for biomedical experimentation. The goals of the BDSC are to provide a collection of documented living stocks of broad value to current research, to preserve documented strains with clear future value, and to provide information and support services that promote maximal exploitation of these materials. These goals facilitate research by providing universal and rapid access to the most generally useful stocks, by preserving specialty genotypes with exceptional characteristics, and by providing information that helps researchers identify stocks appropriate to their needs. Drosophila is used extensively in studies of biological processes relevant to human health and investigations of molecular mechanisms underlying disease, because genetic technologies available to Drosophila researchers are among the most sophisticated in any multicellular organism. As the most comprehensive source of stocks for genetic experimentation with Drosophila, the BDSC is central to the success of many research projects including a large number of NIH grants. The first specific aim of this proposal is to continue acquiring, maintaining and distributing Drosophila strains and to continue developing associated information resources to meet the research needs of Drosophila scientists while maintaining and promoting excellent user support. Key to this aim is the administration and advancement of the highly successful cost recovery program that finances operational expenses from user fees. Consequently, the proposal focuses on support and development of the core management team as the most effective way to leverage the investment of NIH resources. The second specific aim is to undertake research to increase the utility of a subset of BDSC stocks which have been preserved for their distinctive mutant phenotypes. The work will experimentally map mutations in these stocks to specific transcription units in the genome sequence and will substantially increase the usefulness and relevance of the stocks to researchers investigating the functional significance of molecularly defined genes.

描述（由申请人提供）：布卢明顿果蝇储备中心（BDSC）支持一个庞大的全球科学家社区，使用昆虫黑腹果蝇作为生物医学实验的模式生物。BDSC的目标是提供对当前研究具有广泛价值的已记录生物种群的集合，保存具有明确未来价值的已记录菌株，并提供促进最大限度利用这些材料的信息和支持服务。这些目标通过提供普遍和快速获取最普遍有用的种群、保存具有特殊特征的特殊基因型以及提供帮助研究人员确定适合其需要的种群的信息来促进研究。果蝇在生物学研究中被广泛使用