Bloomington Drosophila Stock Center at Indiana University

印第安纳大学布卢明顿果蝇库存中心

• 批准号: 8898260
• 负责人: KEVIN R COOK
• 金额: $ 67.41万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8898260
• 关键词: Accounting; Animal Model; Behavior; Biological Models; Biological Process; Cells; Cellular biology; Characteristics; Collection; Communities; Complex; Consultations; Country; Data; Databases; Development; Discipline; Disease; Drosophila genus; Drosophila melanogaster; Ecology; Equilibrium; Eukaryota; Evolution; Fees; Funding; Future; Genes; Genetic; Genetic Transcription; Genome; Genotype; Goals; Grant; Health; Human; Income; Indiana; Individual; Information Resources; Insecta; Institutes; International; Investigation; Investments; Laboratories; Life; Link; Maintenance; Maps; Methodology; Modeling; Molecular; Mutation; N.I.H. Research Support; Neurobiology; Organism; Phenotype; Physiology; Population Biology; Principal Investigator; Recovery; Research; Research Personnel; Research Project Grants; Resource Development; Resources; Role; Sampling; Scientist; Services; Shipping; Ships; Source; Technology; Tissues; United States National Institutes of Health; Universities; Work; base; cost; disease phenotype; drug discovery; fly; functional genomics; genetic strain; genetic technology; genome sequencing; human disease; improved; medical specialties; meetings; mutant; operation; programs; repository; success; tool; trend; web site

DESCRIPTION (provided by applicant): The Bloomington Drosophila Stock Center (BDSC) supports a large, worldwide community of scientists using the insect Drosophila melanogaster as a model organism for biomedical experimentation. The goals of the BDSC are to provide a collection of documented living stocks of broad value to current research, to preserve documented strains with clear future value, and to provide information and support services that promote maximal exploitation of these materials. These goals facilitate research by providing universal and rapid access to the most generally useful stocks, by preserving specialty genotypes with exceptional characteristics, and by providing information that helps researchers identify stocks appropriate to their needs. Drosophila is used extensively in studies of biological processes relevant to human health and investigations of molecular mechanisms underlying disease, because genetic technologies available to Drosophila researchers are among the most sophisticated in any multicellular organism. As the most comprehensive source of stocks for genetic experimentation with Drosophila, the BDSC is central to the success of many research projects including a large number of NIH grants. The first specific aim of this proposal is to continue acquiring, maintaining and distributing Drosophila strains and to continue developing associated information resources to meet the research needs of Drosophila scientists while maintaining and promoting excellent user support. Key to this aim is the administration and advancement of the highly successful cost recovery program that finances operational expenses from user fees. Consequently, the proposal focuses on support and development of the core management team as the most effective way to leverage the investment of NIH resources. The second specific aim is to undertake research to increase the utility of a subset of BDSC stocks which have been preserved for their distinctive mutant phenotypes. The work will experimentally map mutations in these stocks to specific transcription units in the genome sequence and will substantially increase the usefulness and relevance of the stocks to researchers investigating the functional significance of molecularly defined genes.

描述（由申请人提供）：布卢明顿果蝇库存中心 (BDSC) 支持全球范围内的大型科学家群体，使用昆虫果蝇作为生物医学实验的模式生物。 BDSC 的目标是提供一系列对当前研究具有广泛价值的记录在案的生物种群，保存记录在案的具有明确未来价值的菌株，并提供信息和支持服务，以促进最大限度地利用这些材料。这些目标通过普遍和快速地获取最普遍有用的种群、保留具有特殊特征的特殊基因型以及提供帮助研究人员识别适合其需求的种群的信息来促进研究。果蝇广泛用于生物学研究 与人类健康相关的过程以及疾病分子机制的研究，因为果蝇研究人员可用的遗传技术是所有多细胞生物中最复杂的。作为果蝇基因实验最全面的资源来源，BDSC 对于许多研究项目（包括大量 NIH 拨款）的成功至关重要。该提案的第一个具体目标是继续获取​​、维护和分发果蝇菌株，并继续开发相关信息资源以满足果蝇科学家的研究需求，同时维持和促进优秀的用户支持。这一目标的关键是管理和推进非常成功的成本回收计划，该计划通过用户费用来资助运营费用。因此，该提案重点关注核心管理团队的支持和发展，将其作为利用 NIH 资源投资的最有效方式。第二个具体目标是开展研究，以提高 BDSC 种群子集的实用性，这些种群因其独特的突变表型而得以保留。这项工作将通过实验将这些种群中的突变映射到基因组序列中的特定转录单元，并将大大增加这些种群对研究分子定义基因功能意义的研究人员的有用性和相关性。