Predictors of Psychotherapy Impact Analysis of 6 RCTs in Non Western Countries

非西方国家 6 项随机对照试验的心理治疗影响分析的预测因素

• 批准号: 8961005
• 负责人: Judith Karen Bass
• 金额: $ 32.4万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8961005
• 关键词: Accounting; Adult; Advocate; Affect; Age; Anxiety; Bass; Caring; Characteristics; Code; Cognitive Therapy; Comorbidity; Conflict (Psychology); Coping Skills; Country; Data; Data Analyses; Data Set; Databases; Demographic Factors; Disasters; Disease; Education; Effectiveness; Evidence based treatment; Exposure to; Funding; Future; Grant; Health; Health Personnel; Health Professional; Impairment; Income; Individual; Intervention; Intervention Trial; Jordan; Knowledge; Marital Status; Mental Depression; Mental Health; Meta-Analysis; Methods; Modeling; Movement; National Institute of Mental Health; Participant; Population; Post-Traumatic Stress Disorders; Process; Provider; Psyche structure; Psychotherapy; Randomized Controlled Trials; Reporting; Research; Respondent; Risk; Role; Sampling; Severities; Sorting - Cell Movement; Specialist; Stream; Stress and Coping; Structure; Substance Use Disorder; Survivors; Symptoms; System; Training; Trauma; Treatment Factor; Treatment Protocols; Violence; Work; arm; burden of illness; cognitive process; contextual factors; disability; disability-adjusted life years; evidence base; improved; improved functioning; interpersonal therapy; intervention effect; meetings; mental function; public health relevance; scale up; sex; skills training; success

 DESCRIPTION (provided by applicant): The burden of mental health problems in low- and middle-income countries (LMIC) is substantial. Although the burden associated with these problems is high, the gap between those who suffer from them and those who receive any sort of evidence-based treatment is large. Among the factors associated with this treatment gap in LMIC is the scarcity of trained mental health professionals, leading to the growing movement advocating use of non-specialists in task-sharing models to provide evidence-based treatments. Despite the growing number of rigorous studies showing promising effects of psychotherapeutic interventions provided through task-sharing strategies by non-specialist mental health providers, a gap exists in our knowledge as to modifying factors and demographic characteristics that influence the magnitude of these intervention impacts because the intervention trials have not been powered to examine effects by sub-groups providing little information about which treatments work best for which participants. Study Methods: The proposed study will evaluate the modifying effects of individual, symptom specific and contextual factors on the utilization and impacts of psychotherapy provided by non-specialist providers using data from six randomized controlled trials in LMIC across 4 continents. This synthesis will use integrative data analysis of pooled data (i.e., combining and analyzing individual-level data across numerous studies using coordinated coding and analysis methods that maximize precision of comparisons). The Specific Aims include Aim 1: building a consolidated database of respondents from the trials which have a combined baseline sample of n=1611. And the following aims which look at different factors that may predict differential utilization and impacts of psychotherapy provided by non-specialist providers: Aim 2: Identify individual factors such as sex, age, education, marital status, and trauma exposure; Aim 3: Identify factors related to symptoms, disorders, and impairment such as symptom severity, and increased impairment; Aim 4: Identify contextual and treatment factors such as degree of insecurity, provider training, provider sex and specific therapy used; and a Secondary Aim: Explore the role of symptom comorbidity. Furthering our understanding of predictors of treatment success, which includes treatment completion, reduced symptomatology, and improved functioning, will identify further adaptations of training and treatment protocols to meet the needs of a wider range of populations in LMIC than is currently able to be treated, an important step for disseminating and scaling up promising treatments, improving the mental health of the population in the LMICs, and reducing the Global Burden of Disease.

 描述（由申请人提供）：低收入和中等收入国家（LMIC）的心理健康问题负担很大。尽管与这些问题相关的负担很高，但患有这些问题的人与接受任何循证治疗的人之间的差距很大。与LMIC中这种治疗差距相关的因素之一是训练有素的心理健康专业人员的稀缺，导致越来越多的运动倡导在任务分担模式中使用非专家来提供循证治疗。尽管越来越多的严谨研究表明，非专业心理健康提供者通过任务分担策略提供的心理治疗干预措施具有良好的效果，我们对影响这些干预影响程度的修正因素和人口统计学特征的认识存在差距，因为干预试验没有足够的动力来检查亚组的影响，小组提供的关于哪种治疗方法对哪种参与者最有效的信息很少。研究方法：拟议的研究将评估个人，症状特异性和背景因素对使用的修改效果， 使用来自四大洲LMIC的六项随机对照试验的数据，研究非专业提供者提供的心理治疗的影响。本综合报告将使用以下综合数据分析： 合并数据（即，使用协调的编码和分析方法组合和分析众多研究中的个体水平数据，以最大限度地提高比较的精度）。具体目标包括目标1：建立来自试验的应答者的统一数据库，这些试验具有n=1611的合并基线样本。以下目标着眼于不同的因素，这些因素可能预测非专业提供者提供的心理治疗的差异利用和影响：目标2：确定个人因素，如性别，年龄，教育，婚姻状况和创伤暴露;目标3：确定与症状，障碍和损伤相关的因素，如症状严重程度和增加的损伤;目标4：确定背景和治疗因素，如不安全程度，提供者培训，提供者性别和使用的特定治疗;和次要目的：探索症状合并症的作用。进一步了解治疗成功的预测因素，包括完成治疗、减少精神病和改善功能，将确定进一步调整培训和治疗方案，以满足中低收入国家比目前能够治疗的更广泛人群的需求，这是传播和扩大有希望的治疗方法的重要一步，改善中低收入国家人口的心理健康，减少全球疾病负担。