Institute for Clinical and Translational Science

联系PD/PI：库珀，DAN M 我们的驱动目标是通过基础转化科学发现切实有益于健康， 执行和培训。UCI临床和转化科学研究所（ICTS）将使广泛的 在我们的机构和我们地区进行的一系列翻译研究在一个特殊的环境中， 质量、安全和效率。我们将为我们的中心提供独特的计划和人才， 创新和持续改进，丰富整个国家网络。我们将创造和跟踪小说 在NCATS概述的每个基本领域的计划：1）劳动力发展：受训人员（在两个 K和NRSA级别）将利用UCI的优势，包括现有的沉浸式培训项目， 例如系统生物学，可以缩短和改善训练经验。社区大学 校外实习将提供广泛的经验学习，包括“健康和司法系统”和“药物 在当地初创企业中的发现。”我们的临床实习生将在所有员工的劳动力发展中发挥不可或缺的作用， 例如我们最近开发的学习协调员认证计划。在UCI的特殊人才， 科学和团队科学的实施导致了团队科学核心课程，这将是 纳入所有信通技术培训。2)协作和参与：ICTS生态系统是我们 学术健康中心积极与区域合作伙伴合作：独立的儿童医院， 橙子县（CHOC），当地的VA，和一个不断发展的社区为基础的负责任的护理组织在我们的 地区信通技术将领导机构和区域努力，提高质量和效率，使我们做好准备， 一个在多中心临床研究中脱颖而出的中心。通过利用成功的临床试验经验 我们的教师，建立在多年的有效的社区外展，我们与社区诊所的整合， 先进的EHR队列发现工具，临床试验应计和保留核心的目的是最佳的 从最年轻的年轻人（早产儿）到最年长的老年人（90岁以上），以及从典型的 临床研究中代表性不足的群体。3)整合：将通过以下方式促进儿童健康研究： 与AAP儿科研究办公室网络合作;正式的研究战略计划 与CHOC;并通过一个可选模块与其他十九个CTSA（儿童健康研究加速 通过多站点规划）。4)方法和过程：我们与五个UC联盟的参与 CTSAs（BRAID-生物医学研究加速集成和开发）已作为测试 多站点研究的新方法的基础。BRAID发起的信任和依赖IRB和UC研究 交换队列发现工具正在被纳入NCATS ACT项目。利用UCI的优势， 运动医学，运动医学和运动科学术语协调（可选 模块）将改变运动生物标志物在临床研究中的使用。总之，翻译研究将 在这种“一切都被质疑，没有现状”的环境中茁壮成长。 项目摘要/摘要第129页 联系PD/PI：库珀，DAN M

Contact PD/PI: COOPER, DAN M Our driving aim is to tangibly benefit health through fundamental translational science discovery, implementation, and training. The UCI Institute for Clinical and Translational Science (ICTS) will enable a wide range of translational research conducted at our institution and in our region in an environment of exceptional quality, safety and efficiency. We will empower programs and talent unique to our Hub that will foster innovation and continuous improvement enriching the entire national network. We will create and track novel programs in each of the essential areas outlined by NCATS: 1) Workforce Development: Trainees (at both the K and NRSA levels) will harness strengths at UCI, including existing immersive training programs in areas such as systems biology that can shorten and improve the training experience. Community-university externships will provide wide-ranging experiential learning including “health and the judicial system” and “drug discovery in local start-ups.” Our clinical trainees will play an integral role in workforce development of all staff, such as our recently developed certification program for study coordinators. Particular talent at UCI in both the science and implementation of team science resulted in a Team Science Core Curriculum, which will be integrated into all ICTS training. 2) Collaboration and Engagement: The ICTS ecosystem is one in which our academic health center actively collaborates with regional partners: the freestanding Children’s Hospital of Orange County (CHOC), the local VA, and a growing community-based accountable care organization in our region. The ICTS will lead an institutional and regional effort to improve quality and efficiency, preparing us as a Hub poised to excel in multicenter clinical investigations. By engaging the successful clinical trial experience of our faculty, building on years of effective community outreach, our integration with community clinics, and advanced EHR cohort discovery tools, the clinical trials Accrual and Retention Core is designed to optimally recruit from the youngest of the young (premature babies) to the oldest of the old (90+), and from typically underrepresented groups in clinical research. 3) Integration: Child health research will be fostered through: collaborations with the AAP Pediatric Research in Office Settings network; a formal Research Strategic Plan with CHOC; and through an Optional Module with nineteen other CTSAs (Child Health Research Acceleration through Multisite Planning). 4) Methods and Processes: Our involvement with the consortium of the five UC CTSAs (BRAID–Biomedical Research Acceleration Integration and Development) has served as a testing ground of novel approaches for multisite research. BRAID-initiated Trust-and-Rely IRB and the UC-Research Exchange cohort discovery tool are being integrated into the NCATS ACT project. Building on UCI strengths in exercise medicine, the Terminology Harmonization in Exercise Medicine and Exercise Science (an Optional Module) will transform the use of exercise biomarkers in clinical research. In sum, translational research will thrive in this environment where “everything is questioned and there is no status quo.” Project Summary/Abstract Page 129 Contact PD/PI: COOPER, DAN M