Institute for Clinical and Translational Science

联系PD/PI：Cooper，Dan M 我们的驱动目标是通过基础翻译科学发现切实造福健康， 实施和培训。UCI临床与翻译科学研究所(ICTS)将使广泛的 在我们机构和我们地区在特殊环境下进行的一系列翻译研究 质量、安全、效率。我们将支持我们中心独有的计划和人才，这些计划和人才将促进 不断创新、不断完善，丰富了整个国家网络。我们将创作和跟踪小说 NCATS概述的每个基本领域的方案：1)劳动力发展：受训人员(在两个方面 K和NRSA级别)将利用UCI的优势，包括现有的沉浸式培训计划 如系统生物学，可以缩短和改善培训体验。社区大学 外部奖学金将提供广泛的经验性学习，包括“健康和司法系统”和“毒品”。 在当地初创企业中的发现。我们的临床实习生将在全体员工的劳动力发展中发挥不可或缺的作用， 例如我们最近为研究协调员开发的认证计划。UCI在这两个领域的特殊才华 科学和团队科学的实施导致了团队科学核心课程，这将是 整合到所有ICTS培训中。2)协作和参与：ICTS生态系统是我们的 学术卫生中心积极与地区合作伙伴合作：独立的儿童医院 奥兰治县(CHOC)、当地退伍军人事务部和我们的不断发展的社区责任关怀组织 区域。信息和通信技术中心将领导机构和区域努力提高质量和效率，使我们做好准备 一个准备在多中心临床研究中脱颖而出的中心。通过参与成功的临床试验经验 在多年有效的社区外展、我们与社区诊所的整合以及 先进的EHR队列发现工具，临床试验应计和保留核心旨在优化 从最小的年轻人(早产儿)到最年长的老年人(90+)，以及从典型的 在临床研究中代表不足的群体。3)一体化：将通过以下方式促进儿童健康研究： 与AAP儿科办公室环境研究网络的合作；正式的研究战略计划 通过CHAC；并通过与其他19个CTSA(儿童健康研究加速)一起的可选模块 通过多站点规划)。4)方法和流程：我们与五个UC联盟的参与 CTSA(辫子-生物医学研究加速集成和开发)作为一种测试 多站点研究的新方法的基础。辫子发起的信任依赖IRB及其UC研究 正在将Exchange队列发现工具集成到NCATS ACT项目中。以UCI的优势为基础 运动医学，运动医学和运动科学中术语的统一(可选 模块)将改变运动生物标记物在临床研究中的使用。总而言之，翻译研究将 在这个“一切都受到质疑，没有现状”的环境中茁壮成长。 项目摘要/摘要页129 联系PD/PI：Cooper，Dan M

Contact PD/PI: COOPER, DAN M Our driving aim is to tangibly benefit health through fundamental translational science discovery, implementation, and training. The UCI Institute for Clinical and Translational Science (ICTS) will enable a wide range of translational research conducted at our institution and in our region in an environment of exceptional quality, safety and efficiency. We will empower programs and talent unique to our Hub that will foster innovation and continuous improvement enriching the entire national network. We will create and track novel programs in each of the essential areas outlined by NCATS: 1) Workforce Development: Trainees (at both the K and NRSA levels) will harness strengths at UCI, including existing immersive training programs in areas such as systems biology that can shorten and improve the training experience. Community-university externships will provide wide-ranging experiential learning including “health and the judicial system” and “drug discovery in local start-ups.” Our clinical trainees will play an integral role in workforce development of all staff, such as our recently developed certification program for study coordinators. Particular talent at UCI in both the science and implementation of team science resulted in a Team Science Core Curriculum, which will be integrated into all ICTS training. 2) Collaboration and Engagement: The ICTS ecosystem is one in which our academic health center actively collaborates with regional partners: the freestanding Children’s Hospital of Orange County (CHOC), the local VA, and a growing community-based accountable care organization in our region. The ICTS will lead an institutional and regional effort to improve quality and efficiency, preparing us as a Hub poised to excel in multicenter clinical investigations. By engaging the successful clinical trial experience of our faculty, building on years of effective community outreach, our integration with community clinics, and advanced EHR cohort discovery tools, the clinical trials Accrual and Retention Core is designed to optimally recruit from the youngest of the young (premature babies) to the oldest of the old (90+), and from typically underrepresented groups in clinical research. 3) Integration: Child health research will be fostered through: collaborations with the AAP Pediatric Research in Office Settings network; a formal Research Strategic Plan with CHOC; and through an Optional Module with nineteen other CTSAs (Child Health Research Acceleration through Multisite Planning). 4) Methods and Processes: Our involvement with the consortium of the five UC CTSAs (BRAID–Biomedical Research Acceleration Integration and Development) has served as a testing ground of novel approaches for multisite research. BRAID-initiated Trust-and-Rely IRB and the UC-Research Exchange cohort discovery tool are being integrated into the NCATS ACT project. Building on UCI strengths in exercise medicine, the Terminology Harmonization in Exercise Medicine and Exercise Science (an Optional Module) will transform the use of exercise biomarkers in clinical research. In sum, translational research will thrive in this environment where “everything is questioned and there is no status quo.” Project Summary/Abstract Page 129 Contact PD/PI: COOPER, DAN M