University of California Health Participation in the National COVID Cohort Collaborative (N3C)

项目摘要 通过这一补充，我们将协调在大学的五个CTSA中心的集体努力， 加州（UC）卫生部向国家COVID队列提供数据，并成为其战略合作伙伴 协作（N3 C）。通过结合加州大学戴维斯分校的数据资源和研究信息学专业知识， 弗朗西斯科、洛杉矶、欧文和圣地亚哥，加州大学健康中心具有独特的优势，可以提供高质量的临床 加州不同患者人群的数据，以帮助N3 C履行其使命，“建立一个 集中的国家数据资源，研究界可以用来研究COVID-19，并确定 随着疫情的不断发展，潜在的治疗方法。”拟议的工作将利用现有的UC- UC COVID研究数据集（UC CORDS），一个持续更新的HIPAA 有限的数据集，包含在任何时间接受COVID-19检测的所有患者的全面临床信息 加州大学健康中心为了确保高质量和及时的数据交付，我们将创建一个UC范围内的治理 代表所有五个UC与NCATS建立主数据传输和使用协议（DTUA CTSA中心，除了协调研究伦理审查。我们还将建立一个信息工作组 让每个UC CTSA中心的关键利益相关者参与协调站点级数据工作。数据汇总、质量 将由中心的UC Health Data Warehouse（UCHDW）团队执行 数据驱动的洞察力和创新（CDI 2）在总统的UC办公室。 术语表 临床试验的ACT累积 CDI 2数据驱动的见解和创新 CDW临床数据仓库 生物医学信息学中心 2019冠状病毒病（COVID-19） CTSA临床和转化科学奖 DTUA数据传输和使用协议 电子健康记录 i2 b2整合生物学和床边的信息学 N3 C国家COVID队列协作 OMOP观察性医疗结果伙伴关系 PCORnet国家以患者为中心的临床研究 网络 共享健康研究信息网络 UC BRAID加州大学生物医学研究 加速、整合和发展 UC CORDS加州大学COVID研究 数据集 加州大学戴维斯分校CTSC加州大学戴维斯分校 翻译科学中心 UC Irvine ICTS加州大学欧文分校 临床和转化科学 UC雷克斯加州大学研究交流中心 UCHDW加州大学健康数据仓库 UCLA CTSI加州大学，洛杉矶临床 翻译科学研究所 加州大学圣地亚哥分校 临床和转化研究所 加州大学旧金山分校弗朗西斯科分校 临床和转化科学研究所

PROJECT SUMMARY Through this supplement, we will orchestrate a collective effort across the five CTSA Hubs at the University of California (UC) Health to contribute data to, and become a strategic partner of, the National COVID Cohort Collaborative (N3C). By combining the data resources and research informatics expertise at UC Davis, San Francisco, Los Angeles, Irvine, and San Diego, UC Health is uniquely positioned to provide high-quality clinical data of diverse patient populations across the State of California to help N3C fulfill its mission to “build a centralized national data resource that the research community can use to study COVID-19 and identify potential treatments as the pandemic continues to evolve.” The proposed work will leverage an existing UC- wide initiative on curating the UC COVID Research Data Set (UC CORDS), a continuously updated HIPAA Limited Data Set that contains comprehensive clinical information of all patients tested for COVID-19 at any UC Health facility. To ensure high-quality and timely data delivery, we will create a UC-wide governance structure to establish a master Data Transfer and Use Agreement (DTUA) with NCATS on behalf of all five UC CTSA Hubs, in addition to coordinating research ethics reviews. We will also create an informatics task force involving key stakeholders at each UC CTSA Hub to coordinate site-level data work. Data aggregation, quality assurance, and submission will be performed by the UC Health Data Warehouse (UCHDW) team at the Center for Data-Driven Insights and Innovation (CDI2) in the UC Office of the President. Glossary ACT Accrual to Clinical Trials CDI2 Data-Driven Insights and Innovation CDW Clinical Data Warehouse CMBI Center for Biomedical Informatics COVID-19 Coronavirus Disease 2019 (COVID-19) CTSA Clinical and Translational Science Awards DTUA Data Transfer and Use Agreement EHR Electronic health records i2b2 Informatics for Integrating Biology and the Bedside N3C National COVID Cohort Collaborative OMOP Observational Medical Outcomes Partnership PCORnet National Patient-Centered Clinical Research Network SHRINE Shared Health Research Information Network UC BRAID University of California Biomedical Research Acceleration, Integration, and Development UC CORDS University of California COVID Research Data Set UC Davis CTSC University of California, Davis Clinical and Translational Science Center UC Irvine ICTS University of California, Irvine Institute for Clinical and Translational Science UC ReX University of California Research Exchange UCHDW University of California Health Data Warehouse UCLA CTSI University of California, Los Angeles Clinical and Translational Science Institute UCSD ACTRI University of California, San Diego Altman Clinical and Translational Research Institute UCSF CTSI University of California, San Francisco Clinical and Translational Science Institute