Institute for Clinical and Translational Science

联系PD/PI：库珀、丹M O.整体 项目摘要 自2010年以来，临床和转化科学研究所（ICTS）在UCI，一个年轻的公立大学， 大力支持转化科学，改变了我们整个医疗保健企业的临床研究。 我们通过打破我们大学传统的学术孤岛，在我们的大学建立强大的合作伙伴关系， 多样化的社区，并在整个CTSA网络中产生创新项目。下一个战略 信息和通信技术阶段解决区域和国家卫生保健方面的重大挑战和未满足的需求。我们 计划建立在良好的成就记录上，包括：1。劳动力发展。我们将发起一项 一系列培训机会，突出多样性和可及性，并创造通往卓越的途径， 为所有ICTS教师，工作人员，合作伙伴和学员提供认证。信息学和质量改进， 所有培训活动都将纳入持续学习的内容。2.协作和参与。我们将 实施团队科学培训，提供将关键利益相关者的观点纳入 临床研究规划。与NCATS试验创新网络合作，我们对社区进行了试点测试， 参与工作室培训模块，并将在整个网络传播该计划。3.一体化到 提高我们的临床试验的覆盖范围，我们将激活UCI团队在招募特殊人群方面的经验， 例如无家可归者、婴儿和儿童、退伍军人、老年人以及拉丁美洲人和亚裔美国人 我们地区的社区。在加州州3000万美元基础设施赠款的帮助下， 为了帮助得不到充分服务的儿童获得保健服务，我们聘请了国家专家进行学习保健系统研究。 我们将启动LHS项目，a）改善对患有慢性病和复杂疾病的儿童的护理， 和B）减轻对老年人的虐待。4.方法和过程。我们把统计人员从 在整个大学，并将提供方便的咨询，为例行和复杂的研究 的设计.源于我们资助的CTSA合作创新奖，我们将试点测试机器语言 在临床研究中使用流式细胞仪分析，并在整个网络中传播这些方法。建筑 基于UCI的专业知识，我们将使用可选功能：a）加速机器人在康复中的使用， 广泛的疾病和伤害，以及B）利用学校体育健身的未实现潜力 通过测试来促进整个生命周期的健康。5.信息学.我们的信息学领导者将建立研究和 新的临床信息学奖学金的培训计划，并为我们最近的临床研究工具开发 Epic EHR 6.多样性与UCI对卓越包容性的承诺相一致，ICTS将建立 新的管道计划，以加强学习，协作和职业机会，在CTS为多样化的队列 的受训者。总之，我们第三个融资周期的主要目标是与我们的350万人合作， 参与和多样化的社区。我们将成为一个转化科学的实验室， 和评估，以“开发，展示和传播”整个网络的新的研究工具。 术语表 临床研究专业人员协会 ADRC阿尔茨海默病研究中心 应用创新中心 CARE-Q加州大学应用研究联盟 道德素质 CBMI生物医学信息中心 CCIA CTSA协作创新奖 CHAMP儿童健康研究加速通过 多站点规划 CPET心脏运动测试 CTTI临床试验转型计划 DTF领域工作队 HOTTs健康导向翻译团队 LHS学习保健系统 MoTrPAC身体活动分子传感器 QbD质量源于设计 RAFT研究加速和促进小组 RISE研究基础设施战略增强 RCR相对引文比率 RTRN Research in Minority Institutions翻译 研究网络 S-BPFT校本体能测试 TBC团队建设会议 训练中的术语协调 医学与运动科学 UC BRAID加州大学生物医学研究 加速、整合和发展 UC雷克斯加州大学研究交流中心 第149页 项目概要/摘要 联系PD/PI：库珀、丹M

Contact PD/PI: Cooper, Dan M O. OVERALL PROJECT SUMMARY Since 2010, the Institute for Clinical and Translational Science (ICTS) at UCI, a young public university that vigorously supports translational science, has transformed clinical research across our healthcare enterprise. We did so by breaking down traditional academic silos at our university, building robust partnerships in our diverse community, and engendering innovative projects throughout the CTSA Network. Strategies for the next phase of ICTS address significant challenges and unmet needs in healthcare regionally and nationally. Our plans, built on a strong record of accomplishment, include: 1. Workforce Development. We will launch a range of training opportunities that highlight diversity and accessibility, and create pathways to excellence and certification for all ICTS faculty, staff, partners, and trainees. Informatics and quality improvement through continuous learning will be embedded in all training activities. 2. Collaboration and engagement. We will implement training in team science, providing skills to incorporate the perspectives of key stakeholders in clinical research planning. Working with the NCATS Trial Innovation Network, we pilot-tested a Community Engagement Studio training module and will disseminate the program across the network. 3. Integration. To improve the reach of our clinical trials, we will activate UCI teams experienced in recruiting special populations, such as the homeless, babies and children, veterans, the elderly, and the Latino and Asian American communities in our region. Aided by a State of California $30 million infrastructure grant to improve access to health care for underserved children, we engaged national experts in learning health systems research (LHS). We will launch LHS projects on a) improving care for children with chronic diseases and complex conditions, and b) mitigating abuse in the elderly. 4. Methods and processes. We coalesced statistical personnel from across the university and will provide easily accessible consultation for both routine and complex study designs. Stemming from our funded CTSA collaboration innovation award, we will pilot test machine-language analytics for flow cytometry in clinical research and disseminate these approaches across the network. Building on UCI expertise, we will use the Optional Functions to: a) accelerate the use of robotics in rehabilitation for a wide range of diseases and injuries, and b) harness the unrealized potential of school-based physical fitness testing to advance health across the lifespan. 5. Informatics. Our informatics leaders will build research and training programs for a new Clinical Informatics Fellowship and develop clinical research tools for our recently deployed Epic EHR. 6. Diversity. In concert with UCI’s commitment to inclusion excellence, ICTS will build new pipeline programs to enhance learning, collaboration, and career opportunities in CTS for a diverse cohort of trainees. In summary, a major goal of our 3rd funding cycle is to partner with the 3.5 million people in our engaged and diverse communities. We will be a laboratory for translational science, integrating data gathering and evaluation to “develop, demonstrate, and disseminate” novel research tools across the network. Glossary ACRP Association of Clinical Research Professionals ADRC Alzheimer’s Disease Research Center CAI Center for Applied Innovation CARE-Q UC-wide Consortium for Applied Research Ethics Quality CBMI Center for Biomedical Informatics CCIA CTSA Collaboration Innovation Award CHAMP Child Health Research Acceleration through Multisite Planning CPET Cardiopulmonary Exercise Testing CTTI Clinical Trials Transformation Initiative DTF Domain Task Force HOTTs Health Oriented Translational Teams LHS Learning Health Systems MoTrPAC Molecular Transducers of Physical Activity QbD Quality by Design RAFT Research Acceleration and Facilitation Team RISE Research Infrastructure Strategic Enhancement RCR Relative Citation Ratio RTRN Research in Minority Institutions Translational Research Network S-BPFT School-Based Physical Fitness Testing TBC Team Building Conference THEMES Terminology Harmonization in Exercise Medicine and Exercise Science UC BRAID University of California Biomedical Research Acceleration, Integration, and Development UC ReX University of California Research Exchange Page 149 Project Summary/Abstract Contact PD/PI: Cooper, Dan M