Anatomical connections subserving the default mode network

支持默认模式网络的解剖连接

• 批准号: 8889983
• 负责人: Sarah Rachel Heilbronner
• 金额: $ 5.6万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-16 至 2017-07-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8889983
• 关键词: 3-Dimensional; Area; Brain region; Cell Density; Cells; Data; Diffusion Magnetic Resonance Imaging; Disease; Distant; Dorsal; Drug Addiction; Fiber; Functional Magnetic Resonance Imaging; Goals; Grant; Human; Internal Capsule; Knowledge; Label; Link; Literature; Location; Major Depressive Disorder; Maps; Medial; Mediating; Mental Depression; Mental disorders; Modeling; Pathway interactions; Prefrontal Cortex; Research; Research Personnel; Rest; Signal Transduction; Structure; Task Performances; Techniques; Testing; Thalamic structure; Tracer; Travel; addiction; anatomical tracing; density; human subject; imaging modality; insight; nervous system disorder; neuroimaging; public health relevance; white matter

DESCRIPTION (provided by applicant): The default mode network (DMN) is a set of brain regions consistently activated at rest and deactivated during task performance. DMN activity is abnormal in many neurological and psychiatric disorders, including major depressive disorder (MDD) and drug addiction. The two main parts of the DMN are the medial prefrontal cortex (mPFC) and posteromedial cortex (PMC), two areas that are spatially distant and have distinct canonical functions. While there is some evidence of direct connections between these general cortical areas, little is known about their specifics and how they link the network together as a whole. I hypothesize that the DMN is linked together by specific hub subareas that contain converging connections from multiple DMN regions, and the cingulum bundle and the internal capsule are the major connecting white matter bundles for this network. Thus, the goal of this proposal is to delineate how anatomical connections and pathways between mPFC and PMC allow them to operate as a network. Combining traditional anatomical techniques with diffusion magnetic resonance imaging (dMRI), I will determine the connections that underlie the DMN. Defining these specific DMN connections will establish the circuitry subserving neuroimaging results. This basic knowledge is fundamental and is the first step in understanding the changes in the DMN in disease. Functional connectivity within the DMN may result from direct anatomical links, indirect ones, or some combination of both. The first overall aim of this grant i to delineate the direct and indirect connections between subregions of the mPFC and PMC to find potential zones of converging connections. Furthermore, dMRI has identified psychiatric disorders, including MDD and addiction, with specific abnormalities within white matter pathways that likely link DMN structures. These abnormalities likely reflect disruption of specific connections. However, the fibers traveling through any given location within a white matter bundle remain unknown. The second and third aims are to establish white matter pathways that connect DMN structures using tracing and dMRI methods. This will link dMRI and anatomical tract-tracing, testing the validity of dMRI and providing a guide for how to interpret its results.

描述（由申请人提供）：默认模式网络（DMN）是一组大脑区域，在任务性能期间持续激活并停用。在许多神经系统和精神疾病中，DMN活性异常，包括重度抑郁症（MDD）和药物成瘾。 DMN的两个主要部分是内侧前额叶皮层（MPFC）和后内侧皮层（PMC），这两个区域在空间上距离且具有独特的规范功能。尽管这些一般皮质区域之间有直接联系的证据，但对它们的细节以及它们如何将网络链接在一起几乎一无所知。我假设DMN通过包含来自多个DMN区域的收敛连接的特定集线器次群链接在一起，而Cingulum Bundle和内部胶囊是该网络的主要连接白质公司捆绑包。因此，该提案的目的是描述MPFC和PMC之间的解剖连接和路径如何使它们作为网络运行。将传统的解剖技术与扩散磁共振成像（DMRI）相结合，我将确定DMN构成的连接。定义这些特定的DMN连接将建立电路下降的神经成像结果。这种基本知识是基本的，并且是理解疾病中DMN变化的第一步。 DMN内的功能连通性可能是由直接解剖链接，间接链接或两者的某种组合引起的。该赠款I的第一个总体目的是描述MPFC和PMC子区域之间的直接和间接连接，以找到收敛连接的潜在区域。此外，DMRI已经确定了包括MDD和成瘾在内的精神疾病，并具有可能连接DMN结构的白质途径中的特定异常。这些异常可能反映了特定的破坏 连接。但是，穿过白色物质束中任何给定位置的纤维仍然未知。第二和第三的目的是建立使用跟踪和DMRI方法连接DMN结构的白质途径。这将链接DMRI和解剖区追踪，测试DMRI的有效性，并为如何解释其结果提供指南。