Revealing functional networks and circuits of the posteromedial cortex with anatomical connectivity

揭示具有解剖连接性的后内侧皮质的功能网络和回路

基本信息

批准号：
10292991
负责人：
Sarah Rachel Heilbronner
金额：
$ 37.68万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-11-07 至 2023-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10292991
关键词：
Anatomy Anxiety Area Arousal Attention Axon Biological Biology Brain Brain region Cells Cognitive Complex Corpus striatum structure Data Deep Brain Stimulation Diffusion Magnetic Resonance Imaging Disease Dorsal Etiology Fiber Goals Human Impaired cognition Individual Injections Intervention Knowledge Label Laboratories Link Macaca mulatta Major Depressive Disorder Maps Medial Mental Depression Mental disorders Methods Neurons Non-Invasive Cancer Detection Pathway interactions Pattern Population Projection Positioning Attribute Post-Traumatic Stress Disorders Prefrontal Cortex Research Research Personnel Rest Rewards Role Schizophrenia Scientist Self Perception Social Anxiety Disorder Temporal Lobe Tracer Transcranial magnetic stimulation Ventral Striatum Work base cingulate cortex connectome diffusion weighted experimental study improved neuroimaging neuronal circuitry neuroregulation nonhuman primate patient population relating to nervous system response white matter

项目摘要

Project Summary The posteromedial cortex is a brain region that is especially abnormal in many psychiatric diseases, including depression, schizophrenia, and anxiety. However, it has traditionally received little attention from neuroscientists, in part because we do not understand its underlying biology. We propose to remedy this problem by uncovering posteromedial cortical circuits using tract-tracing in nonhuman primates and diffusion- weighted magnetic resonance imaging in nonhuman primates and humans. This pipeline will allow us to create a segmentation of the posteromedial cortex according to its anatomical connectivity. First, we propose to tile the nonhuman primate posteromedial cortex with tract-tracer injections, which will allow us to analyze its connectivity with other, better-understood brain regions. We will use these data to segment the posteromedial cortex according to its anatomical connectivity. We expect that different segments will connect with distinct, well-defined networks within the brain. Next, we will collect diffusion-weighted neuroimaging data in nonhuman primates and humans. Although this method allows noninvasive detection of some connections, it is highly susceptible to errors. We will use the principles of white matter organization identified in the tract-tracing data to guide and debug these neuroimaging data. Because tract-tracing cannot be performed in humans, this pipeline offers a rare possibility to infer anatomical connectivity in the human brain. Finally, based on prior neuroimaging experiments, scientists have hypothesized that the posteromedial cortex may connect with a particularly large number of brain regions and networks. Thus, we would like to determine the extent of axonal collateralization in the neurons of this brain region. In other words, does a single posteromedial cortical neuron project to many other brain regions, or are the circuits largely separate? Together, we expect these projects will elucidate PMC anatomical connectivity in such a way that large-scale neuroimaging networks can be linked with specific neuronal circuits.

项目摘要后内侧皮质是一个大脑区域，在许多精神病中尤为异常，包括抑郁症，精神分裂症和焦虑。但是，传统上几乎没有受到关注神经科学家，部分原因是我们不了解其潜在的生物学。我们建议解决这个问题通过在非人类灵长类动物和扩散中使用道追踪探测后内侧皮质回路的问题非人类灵长类动物和人类中的加权磁共振成像。该管道将使我们能够创建根据其解剖连通性对后内侧皮质进行分割。首先，我们建议瓷砖带有道追踪的非人类灵长类动物后体皮层，这将使我们能够分析其与其他更好理解的大脑区域的连通性。我们将使用这些数据分割后代皮质根据其解剖连通性。我们希望不同的细分市场将与不同的联系大脑中定义明确的网络。接下来，我们将收集非人类的扩散加权神经影像学数据灵长类动物和人类。尽管这种方法允许对某些连接的无创检测，但它是高度的容易受到错误。我们将使用在路追踪数据中确定的白质组织的原理指导和调试这些神经影像数据。因为无法在人类中进行探针，所以管道提供了推断人脑解剖连通性的罕见可能性。最后，基于先验神经影像学实验，科学家假设后体皮层可能与特别是大量大脑区域和网络。因此，我们想确定轴突的程度该大脑区域的神经元的抵押。换句话说，单个后代皮质神经元投影到许多其他大脑区域，还是电路大部分是分开的？在一起，我们期望这些项目将以大规模神经影像网络的方式阐明PMC解剖连通性具有特定的神经元电路。