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Revealing functional networks and circuits of the posteromedial cortex with anatomical connectivity

揭示具有解剖连接性的后内侧皮质的功能网络和回路

基本信息

批准号：
10516723
负责人：
Sarah Rachel Heilbronner
金额：
$ 1.56万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-11-07 至 2023-06-09
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10516723
关键词：
Anatomy Anxiety Area Arousal Attention Axon Biological Biology Brain Brain region Cells Cognitive Complex Corpus striatum structure Data Deep Brain Stimulation Diffusion Magnetic Resonance Imaging Disease Dorsal Etiology Fiber Goals Human Impaired cognition Individual Injections Intervention Knowledge Label Laboratories Link Macaca mulatta Major Depressive Disorder Maps Medial Mental Depression Mental disorders Methods Neurons Non-Invasive Detection Pathway interactions Pattern Population Projection Positioning Attribute Post-Traumatic Stress Disorders Predisposition Prefrontal Cortex Research Research Personnel Rest Rewards Role Schizophrenia Scientist Self Perception Social Anxiety Disorder Temporal Lobe Tracer Transcranial magnetic stimulation Ventral Striatum Work base cingulate cortex connectome diffusion weighted experimental study improved neural neuroimaging neuronal circuitry neuroregulation nonhuman primate patient population response white matter

项目摘要

Project Summary The posteromedial cortex is a brain region that is especially abnormal in many psychiatric diseases, including depression, schizophrenia, and anxiety. However, it has traditionally received little attention from neuroscientists, in part because we do not understand its underlying biology. We propose to remedy this problem by uncovering posteromedial cortical circuits using tract-tracing in nonhuman primates and diffusion- weighted magnetic resonance imaging in nonhuman primates and humans. This pipeline will allow us to create a segmentation of the posteromedial cortex according to its anatomical connectivity. First, we propose to tile the nonhuman primate posteromedial cortex with tract-tracer injections, which will allow us to analyze its connectivity with other, better-understood brain regions. We will use these data to segment the posteromedial cortex according to its anatomical connectivity. We expect that different segments will connect with distinct, well-defined networks within the brain. Next, we will collect diffusion-weighted neuroimaging data in nonhuman primates and humans. Although this method allows noninvasive detection of some connections, it is highly susceptible to errors. We will use the principles of white matter organization identified in the tract-tracing data to guide and debug these neuroimaging data. Because tract-tracing cannot be performed in humans, this pipeline offers a rare possibility to infer anatomical connectivity in the human brain. Finally, based on prior neuroimaging experiments, scientists have hypothesized that the posteromedial cortex may connect with a particularly large number of brain regions and networks. Thus, we would like to determine the extent of axonal collateralization in the neurons of this brain region. In other words, does a single posteromedial cortical neuron project to many other brain regions, or are the circuits largely separate? Together, we expect these projects will elucidate PMC anatomical connectivity in such a way that large-scale neuroimaging networks can be linked with specific neuronal circuits.

项目概要后内侧皮质是在许多精神疾病中尤其异常的大脑区域，包括抑郁症、精神分裂症和焦虑症。但传统上它很少受到关注神经科学家，部分原因是我们不了解其基础生物学。我们建议对此进行补救通过使用非人类灵长类动物的束追踪和扩散来揭示后内侧皮质回路来解决问题非人类灵长类动物和人类的加权磁共振成像。该管道将允许我们创建根据其解剖连接性对后内侧皮质进行分割。首先，我们建议平铺非人类灵长类动物后内侧皮质注射了束示踪剂，这将使我们能够分析其与其他更容易理解的大脑区域的连接。我们将使用这些数据来分割后内侧皮质根据其解剖连接性。我们预计不同的细分市场将与不同的、大脑内定义明确的网络。接下来，我们将收集非人类的扩散加权神经影像数据灵长类动物和人类。虽然这种方法可以非侵入性地检测某些连接，但它的效率很高。容易出错。我们将使用在纤维束追踪数据中确定的白质组织原理指导和调试这些神经影像数据。由于管道追踪无法在人类身上进行，因此管道为推断人脑的解剖连接性提供了罕见的可能性。最后根据之前的通过神经影像实验，科学家们假设后内侧皮层可能与特别大量的大脑区域和网络。因此，我们想确定轴突的范围该大脑区域神经元的抵押。换句话说，单个后内侧皮质神经元投射到许多其他大脑区域，或者这些回路基本上是分开的？我们共同期待这些项目将通过连接大规模神经影像网络的方式阐明 PMC 解剖连接性具有特定的神经元回路。