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Anatomical connections subserving the default mode network

支持默认模式网络的解剖连接

基本信息

批准号：
9088499
负责人：
Sarah Rachel Heilbronner
金额：
$ 6万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-07-16 至 2017-07-15
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The default mode network (DMN) is a set of brain regions consistently activated at rest and deactivated during task performance. DMN activity is abnormal in many neurological and psychiatric disorders, including major depressive disorder (MDD) and drug addiction. The two main parts of the DMN are the medial prefrontal cortex (mPFC) and posteromedial cortex (PMC), two areas that are spatially distant and have distinct canonical functions. While there is some evidence of direct connections between these general cortical areas, little is known about their specifics and how they link the network together as a whole. I hypothesize that the DMN is linked together by specific hub subareas that contain converging connections from multiple DMN regions, and the cingulum bundle and the internal capsule are the major connecting white matter bundles for this network. Thus, the goal of this proposal is to delineate how anatomical connections and pathways between mPFC and PMC allow them to operate as a network. Combining traditional anatomical techniques with diffusion magnetic resonance imaging (dMRI), I will determine the connections that underlie the DMN. Defining these specific DMN connections will establish the circuitry subserving neuroimaging results. This basic knowledge is fundamental and is the first step in understanding the changes in the DMN in disease. Functional connectivity within the DMN may result from direct anatomical links, indirect ones, or some combination of both. The first overall aim of this grant i to delineate the direct and indirect connections between subregions of the mPFC and PMC to find potential zones of converging connections. Furthermore, dMRI has identified psychiatric disorders, including MDD and addiction, with specific abnormalities within white matter pathways that likely link DMN structures. These abnormalities likely reflect disruption of specific connections. However, the fibers traveling through any given location within a white matter bundle remain unknown. The second and third aims are to establish white matter pathways that connect DMN structures using tracing and dMRI methods. This will link dMRI and anatomical tract-tracing, testing the validity of dMRI and providing a guide for how to interpret its results.

描述（由申请人提供）：默认模式网络（DMN）是一组在休息时持续激活并在任务执行期间停用的大脑区域。DMN活性在许多神经和精神疾病中是异常的，包括重度抑郁症（MDD）和药物成瘾。DMN的两个主要部分是内侧前额叶皮层（mPFC）和后内侧皮层（PMC），这两个区域在空间上相距很远，具有不同的典型功能。虽然有一些证据表明这些一般皮层区域之间存在直接联系，但对它们的具体细节以及它们如何将网络作为一个整体联系在一起知之甚少。我假设，DMN是由特定的枢纽子区域，包含从多个DMN区域的会聚连接连接在一起，扣带束和内囊是这个网络的主要连接白色物质束。因此，本提案的目标是描述mPFC和PMC之间的解剖学连接和通路如何使它们作为网络运行。结合传统的解剖技术和弥散磁共振成像（dMRI），我将确定DMN的基础连接。定义这些特定的DMN连接将建立有助于神经成像结果的电路。这些基本知识是基础，是了解疾病中DMN变化的第一步。 DMN内的功能连接可能来自直接解剖学连接、间接解剖学连接或两者的某种组合。该补助金的第一个总体目标是描绘mPFC和PMC次区域之间的直接和间接联系，以找到潜在的融合联系区。此外，dMRI已经确定了精神疾病，包括MDD和成瘾，在白色物质通路内可能连接DMN结构的特定异常。这些异常可能反映了特定的连接.然而，在一束白色物质中，穿过任何给定位置的纤维仍然是未知的。第二个和第三个目标是建立白色物质通路，使用跟踪和dMRI方法连接DMN结构。这将把dMRI和解剖追踪联系起来，测试dMRI的有效性，并为如何解释其结果提供指导。