Temperamental emotionality in preschoolers and depression risk

学龄前儿童的气质情绪与抑郁风险

• 批准号: 9981825
• 负责人: Daniel N Klein
• 金额: $ 78.95万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9981825
• 关键词: 21 year old; 3 year old; Adolescence; Adult; Age; Age Factors; Age-Years; Anxiety; Anxiety Disorders; Area; Aversive Stimulus; Behavioral; Child; Childhood; Clinical; Communities; Data; Data Analytics; Data Set; Depressed mood; Depressive disorder; Desire for food; Development; Disease; Early Intervention; Early identification; Electrophysiology (science); Emotional; Event-Related Potentials; Exhibits; Family Relationship; Family history of; Frequencies; Goals; Impairment; Incidence; Intercept; Laboratories; Lead; Life Stress; Link; Longevity; Longitudinal Studies; Machine Learning; Maps; Measures; Mediating; Mental Depression; Mental disorders; Modeling; Morbidity - disease rate; National Institute of Mental Health; Negative Valence; Neurobiology; Onset of illness; Pathway interactions; Phase; Play; Positive Valence; Predictive Value; Procedures; Process; Psychopathology; Research Domain Criteria; Risk; Risk Factors; Role; Sampling; Social Processes; Specificity; Stimulus; Strategic Planning; Stress; Substance Use Disorder; Symptoms; System; Techniques; Temperament; Testing; Time; biobehavior; clinically significant; cohort; depressive symptoms; economic cost; emerging adult; emerging adulthood; indexing; information processing; middle childhood; mortality; nerve stem cell; neurodevelopment; novel; peer; prevent; prospective; psychosocial; relating to nervous system; response; social; social media

PROJECT SUMMARY Depressive disorders (DD) are one of the most prevalent forms of mental disorders, and are associated with significant mortality, morbidity, and economic costs. The incidence of DD begins to increase in early-mid adolescence and peaks in emerging adulthood. The Stony Brook Temperament Study is a longitudinal study that seeks to identify early behavioral and neural precursors and risk factors for DD and understand the neurobiological and psychosocial processes through which these early manifestations develop into clinically significant psychopathology. We initially assessed a large community sample of 3-year old children, and have followed them at 3-year intervals through age 15. This competing renewal application seeks to re-evaluate the sample at ages 18 and 21. Specifically, we propose to trace pathways from laboratory observations of temperamental low positive emotionality and high negative emotionality at age 3 to neural indices of emotional and social information processing and DD symptoms and onsets from middle childhood through emerging adulthood. In addition, we seek to understand how life stress over the lifespan and the developmental challenges of emerging adulthood contribute to risk for DD, and to examine the specificity of these risk pathways in comparison with anxiety and substance use disorders. Finally, we will use cutting-edge machine learning techniques to maximize prediction of DD and understand which domains and developmental periods contribute most to prediction. This information about risk pathways and processes should contribute to understanding when and how to intervene in order to prevent DD and limit their progression.

项目摘要 抑郁症（DD）是精神障碍的最普遍形式之一，并且与 显著的死亡率、发病率和经济成本。DD的发病率在早中期开始增加， 青春期和成年期的高峰期。斯托尼布鲁克气质研究是一项纵向研究 旨在确定DD的早期行为和神经前体和风险因素，并了解 神经生物学和心理社会过程，通过这些早期表现发展为临床 重要的精神病理学我们最初评估了3岁儿童的大型社区样本， 每隔3年对他们进行一次跟踪调查，直到他们15岁。这一竞争性续期申请旨在重新评估 18岁和21岁的样本。具体来说，我们建议从实验室观察中追踪 3岁时气质性低的正性情绪和高的负性情绪对情绪神经指标的影响 和社会信息处理和DD症状和发病从童年中期到新兴 成年此外，我们试图了解生活压力如何在生命周期和发展过程中， 成年期的挑战有助于DD的风险，并检查这些风险的特异性 与焦虑和物质使用障碍相比。最后，我们将使用尖端的机器 学习技术以最大限度地预测DD并了解哪些领域和发展时期 对预测贡献最大。关于风险途径和过程的信息应有助于 了解何时以及如何进行干预，以预防DD并限制其进展。