Research Training in the Major Psychoses and Clinical Neurobiology

描述(由申请人提供)：此申请要求继续资助一个非常成功和完善的博士后培训计划(可追溯到1991年)，主要是精神病和转化临床神经科学。它寻求将翻译临床神经科学方面的培训与重点放在精神分裂症和其他主要精神病的研究上，并使用“寿命轨迹视角”。也就是说，受训者可能会在他们特有的发病年龄研究疾病，但他们也可能从神经发育和/或衰老过程的角度来研究这些疾病。这项综合性翻译临床神经科学课程将重点放在所有三个方面：“综合性”、“翻译/临床”和“神经科学”。最终目标是培养一批年轻的研究人员，他们将对临床现象的复杂性具有高度的成熟度，并在神经科学的某些特定领域奠定坚实的基础，如神经成像、认知神经科学和遗传学/基因组学/分子生物学。该计划每年支持五个实习生名额。学员将在该项目中停留至少两年，许多人选择继续他们的培训总共三年，因为从事复杂的综合性转化临床神经科学固有的复杂性。进入该项目的最低经验要求是博士学位(M.D.，Ph.D.)，但我们的许多实习生也完成了住院医师培训，拥有医学博士/博士学位。我们希望，基础科学和临床科学的结合将有助于确定主要精神病的机制和原因，并提出改进的治疗或预防方法。根据世界卫生组织最近的一项研究，通过该项目研究的障碍(精神分裂症、抑郁症和躁郁症)是造成“全球疾病负担”的十大因素中的三个。因此，至关重要的是，我们必须培训年轻一代的研究人员，他们将在未来几十年里增进对这些疾病的了解。

DESCRIPTION (provided by applicant): This application requests continuation of funding for a very successful and well-established post-doctoral training program (dating back to 1991) in Major Psychoses and Translational Clinical Neuroscience. It seeks to integrate training in translational clinical neuroscience with an emphasis on the study of schizophrenia and other major psychoses using a "lifespan trajectory perspective." That is, trainees may study illnesses during their characteristic age of onset, but they may also examine them from the perspectives of neurodevelopmental and/or aging processes. This program in integrative translational clinical neuroscience will place strong emphasis on all three aspects: "integrative," "translational/clinical," and "neuroscience." The ultimate goal is to train a group of young investigators who will combine a high level of sophistication about the complexities of clinical phenomena with a firm grounding in some specific area of neuroscience, such as neuroimaging, cognitive neuroscience, and genetics/genomics/molecular biology. The program supports five trainee slots/year. Trainees remain in the program for a minimum of two years, and many elect to continue their training for a total of three years because of the complexities inherent in doing sophisticated integrative translational clinical neuroscience. The minimum experience required for entry into the program is a doctoral degree (M.D., Ph.D.), but many of our trainees have also completed residency training and have M.D./Ph.D.s. Relevance An integration of basic and clinical science will, we hope, help identify the mechanisms and causes of the major psychoses and to suggest improved methods for treating or preventing them. The disorders studied through this program (schizophrenia, depression, and bipolar illness) are three of the top ten contributors to the "global burden of disease," according to a recent study by the World Health Organization. Thus it is crucial that we train a young generation of investigators who will advance knowledge about these diseases over the coming decades.