Research Training in the Major Psychoses and Clinical Neurobiology

描述（由申请人提供）：本申请要求继续资助一个非常成功和完善的博士后培训计划（可追溯到1991年）在重大精神病和转化临床神经科学。它旨在整合转化临床神经科学的培训，重点是使用“生命轨迹观点”研究精神分裂症和其他主要精神病。“也就是说，学员可以在疾病特征发病年龄期间研究疾病，但他们也可以从神经发育和/或衰老过程的角度来研究疾病。这个综合转化临床神经科学课程将重点放在三个方面：“综合”，“转化/临床”和“神经科学”。“最终目标是培养一批年轻的研究人员，他们将联合收割机结合对临床现象复杂性的高度复杂性和神经科学某些特定领域的坚实基础，如神经成像，认知神经科学和遗传学/基因组学/分子生物学。该计划每年支持五个实习生名额。受训者在该计划中至少停留两年，许多人选择继续接受为期三年的培训，因为进行复杂的综合转化临床神经科学的复杂性。进入该计划所需的最低经验是博士学位（医学博士，Ph.D.），但我们的许多学员也完成了住院医师培训，并获得了医学博士学位。博士学位我们希望，基础科学和临床科学的结合将有助于确定主要精神病的机制和原因，并提出治疗或预防这些疾病的改进方法。根据世界卫生组织最近的一项研究，通过该项目研究的疾病（精神分裂症、抑郁症和双相情感障碍）是“全球疾病负担”的十大贡献者之三。因此，至关重要的是，我们要培养年轻一代的研究人员，他们将在未来几十年内推动对这些疾病的认识。

DESCRIPTION (provided by applicant): This application requests continuation of funding for a very successful and well-established post-doctoral training program (dating back to 1991) in Major Psychoses and Translational Clinical Neuroscience. It seeks to integrate training in translational clinical neuroscience with an emphasis on the study of schizophrenia and other major psychoses using a "lifespan trajectory perspective." That is, trainees may study illnesses during their characteristic age of onset, but they may also examine them from the perspectives of neurodevelopmental and/or aging processes. This program in integrative translational clinical neuroscience will place strong emphasis on all three aspects: "integrative," "translational/clinical," and "neuroscience." The ultimate goal is to train a group of young investigators who will combine a high level of sophistication about the complexities of clinical phenomena with a firm grounding in some specific area of neuroscience, such as neuroimaging, cognitive neuroscience, and genetics/genomics/molecular biology. The program supports five trainee slots/year. Trainees remain in the program for a minimum of two years, and many elect to continue their training for a total of three years because of the complexities inherent in doing sophisticated integrative translational clinical neuroscience. The minimum experience required for entry into the program is a doctoral degree (M.D., Ph.D.), but many of our trainees have also completed residency training and have M.D./Ph.D.s. Relevance An integration of basic and clinical science will, we hope, help identify the mechanisms and causes of the major psychoses and to suggest improved methods for treating or preventing them. The disorders studied through this program (schizophrenia, depression, and bipolar illness) are three of the top ten contributors to the "global burden of disease," according to a recent study by the World Health Organization. Thus it is crucial that we train a young generation of investigators who will advance knowledge about these diseases over the coming decades.