Frontiers in Stem Cells and Regeneration Course

描述(由申请人提供)：多能干细胞和再生医学是迅速崛起的领域，在NIH的临床、翻译、生物医学和行为组合的整个范围内都具有巨大的生物医学意义。这份新的R25申请申请为我们的高级培训课程寻求五年的赞助，名为：干细胞和再生的前沿(FrSCR)，每年在伍兹霍尔的MBL举办，由Jennifer Morgan(MBL)和Gerald Schatten(匹兹堡)共同担任董事。FSCR是从我们目前资助的U13奖发展而来的，我们在过去几年里在伍兹霍尔成功地提供了这一奖项。FSCR建立在现有课程的显著优势和成功的基础上，同时扩展到纳入新的、重要的生物医学概念和再生和多能性方面的尖端技术突破。这门课程使参与培训的学员能够在多潜能干细胞(PSC)和再生医学领域开始成功的研究计划，包括多潜能成体干细胞(ASC)。我们为学员提供实验室技术、职业指导和PSC研究的伦理法律社会影响(ELSI)方面的必要知识，以极大地促进他们成功进入该领域。为了实现这一目标，我们提出了以下具体目标：1.深入讲授干细胞和再生的基本概念。2.提供有关使用尖端技术进行干细胞实验和再生的详细方法的实践培训。3.就该领域的未决问题以及如何利用干细胞和再生生物学解决与人类发育和生殖障碍有关的问题对受训者进行教育。4.为职业规划和晋升提供机会，并就再生医学研究所涉及的法律、道德和监管领域对受训人员进行教育。5.营造一个国际化的大学环境，为学生提供长期互动和合作的网络机会。FSCR是一个充满活力和不断发展的实体，每年提供一系列关于新兴概念的新的每日讲座，随后是为期一周的延长讨论、实验室研究、技术密集讲习班和非正式研讨会。本课程面向那些致力于基础、转化性或最终临床研究的资深研究员和新独立的科学家。这门课程解决了当前的主要问题，然后是批判性的讨论和实验室实验，在这些实验中，提出了先进的新技术来探索这些问题。因此，这门课程将通过培训新的研究人员为生物医学研究提供显著的好处。 在干细胞和再生领域。

DESCRIPTION (provided by applicant): Pluripotent stem cells and regenerative medicine are rapidly emerging fields with enormous biomedical implications across the entire spectrum of NIH's clinical, translational, biomedical and behavioral portfolios. This new R25 application seeks five years of sponsorship for our advanced training course entitled: Frontiers in Stem Cells and Regeneration (FrSCR) held annually at the MBL in Woods Hole under the Co-Directorship of Jennifer Morgan (MBL) and Gerald Schatten (Pittsburgh). FrSCR developed from our currently funded U13 award, which we offered successfully at Woods Hole during the past years. FrSCR builds on the significant strengths and successes of the existing course, while expanded to incorporate emerging, important biomedical concepts and sophisticated technological breakthroughs in regeneration and pluripotency. This course enables participating trainees to start successful research programs in the fields of pluripotent stem cells (PSC) and regenerative medicine, including multipotent adult stem cells (ASC). We provide trainees the necessary knowledge of laboratory techniques, career mentoring and ethical legal societal impact (ELSI) of PSC research to greatly enhance their successful entry into this field. In order to achieve this goal, we propose the following specific aims: 1. To provide in-depth instruction on the fundamental concepts in stem cells and regeneration. 2. To provide hands-on training in the detailed methods for experimentation with stem cells and regeneration, using cutting-edge techniques. 3. To educate trainees on the open questions in the field, and how stem cells and regenerative biology can be used to solve problems related to human developmental and reproductive disorders. 4. To provide opportunities for career planning and advancement, and to educate trainees on the legal, ethical, and regulatory landscape in which regenerative medicine research occurs. 5. To foster a collegial, international environment, and to provide students with networking opportunities that lead to long-term interactions and collaborations. FrSCR is a dynamic and evolving entity that each year offers a fresh series of daily lectures on emerging concepts, followed by extended discussions, laboratory research, technologically intense workshops and informal seminars over a week-long period. The course is directed towards established investigators as well as advanced fellows and newly independent scientists who are committed to fundamental, translational or eventual clinical research studies. The course addresses major current problems, followed by critical discussions and laboratory experiments in which advanced new techniques are presented to explore these problems. Thus, this course will provide a significant benefit to biomedical research through the training of new investigators in the field of stem cells and regeneration.