Molecular Mycology: Current Approaches to Fungal Pathogenesis

分子真菌学：真菌发病机制的最新方法

• 批准号: 8203997
• 负责人: WILLIAM S. REZNIKOFF
• 金额: $ 0.8万
• 依托单位: MARINE BIOLOGICAL LABORATORY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8203997
• 关键词: Acquired Immunodeficiency Syndrome; Address; Animal Model; Antifungal Agents; Antifungal Therapy; Area; Aspergillus; Autoimmune Diseases; Bacterial Infections; Biological; Candida; Cell Culture Techniques; Chimeric Proteins; Clinical; Collaborations; Communities; Cryptococcus; Diagnostic; Disease; Education; Educational Curriculum; Elements; Ensure; Environment; Faculty; Fostering; Functional disorder; Funding; Funding Agency; Fungal Proteins; Genes; Genetic Techniques; Goals; Human; Immune response; Immunocompromised Host; In Vitro; Incidence; Individual; Infection; Institutes; Invertebrates; Laboratories; Lead; Leadership; Life; Malignant Neoplasms; Marines; Massachusetts; Medical; Mission; Modeling; Molecular; Molecular Analysis; Molecular Genetics; Mycoses; National Institute of Allergy and Infectious Disease; Organ Transplantation; Organism; Ownership; Parasitic Diseases; Pathogenesis; Patients; Pharmaceutical Preparations; Pharmacologic Substance; Play; Populations at Risk; Postdoctoral Fellow; Predisposition; Process; Recording of previous events; Recruitment Activity; Research; Research Personnel; Resources; Role; Scientist; Severities; Staining method; Stains; Students; Techniques; The science of Mycology; Training; Transplant Recipients; Virulence; Virus Diseases; Visit; Wood material; career; comparative; cost; design; experience; functional genomics; fungus; genetic manipulation; graduate student; insight; lecturer; meetings; mutant; next generation; novel; novel diagnostics; novel therapeutics; pathogen; patient population; research study; time use; tool

DESCRIPTION (provided by applicant): The Molecular Mycology Course at the Marine Biological Laboratory (MBL) in Woods Hole, Massachusetts is an intensive training course for research on human fungal pathogens. This course is designed for advanced graduate students, post-doctoral fellows, and faculty. Over the past fourteen years, this course has successfully advanced both the use of genetic techniques in the study of pathogenic fungi and the use of in vitro, cell culture and animal models of human fungal infections and their treatment. The course has also been responsible for recruiting outstanding new investigators to the field of medical mycology. A major part of the course is the participation of a large number of faculty from within the fungal pathogenesis community. Interaction between students and faculty in the intimate setting of the MBL provides connections for the students as they launch independent careers. Furthermore, the course has a history of fostering highly productive collaborations between mycology research teams. Thus, the course has played a major role in elevating the level at which fungal pathogenesis research is performed, fostering interactions and the exchange of ideas within the community, and advancing the careers of individuals who are now becoming leaders in the field. The Molecular Mycology course is evolving to meet the needs of the current students. The course has begun a process of rotating leadership to ensure broad representation and ownership within the fungal community, and new experiments and topics at the cutting edge of the field are continually added to the curriculum. While the Molecular Mycology course has been largely supported by several funding sources in the past, including student tuition, the Burroughs Wellcome Fund, the Howard Hughes Medical Institute, the MBL Educational office, and various pharmaceutical companies, these funding sources may not be sufficient to both maintain and develop scientific excellence and to keep student costs low enough that we can recruit the most promising and diverse class possible as we move forward. Thus, the course seeks to partner with NIAID to develop sustained and adequate funding. With such support, the MBL Molecular Mycology course directors and faculty will be able to continue to train the next generation of leaders in medical mycology research who will be instrumental in revealing the key elements of fungal diseases, and developing new therapeutic and diagnostic tools for the management of human fungal infections. PUBLIC HEALTH RELEVANCE: The Molecular Mycology Course at the Marine Biological Laboratories has been an important resource of the medical mycology research community since its inception fourteen years ago. The goal of this course is to train the next generation of leaders in medical mycology research. These scientists will lead the field in developing new therapeutic and diagnostic strategies for life-threatening fungal infections in humans.

描述（由申请人提供）：位于马萨诸塞州伍兹霍尔的海洋生物实验室（MBL）的分子真菌学课程是针对人类真菌病原体研究的强化培训课程。本课程是专为高级研究生，博士后研究员和教师。在过去的14年里，这门课程成功地推进了遗传技术在致病真菌研究中的应用，以及人类真菌感染及其治疗的体外细胞培养和动物模型的应用。该课程还负责为医学真菌学领域招募优秀的新研究人员。该课程的一个主要部分是来自真菌发病机理社区的大量教师的参与。学生和教师之间的互动在MBL的亲密设置为学生提供连接，因为他们推出独立的职业生涯。此外，该课程有培养真菌学研究团队之间的高效合作的历史。因此，该课程在提升真菌致病机理研究的水平，促进社区内的互动和思想交流，以及推进现在成为该领域领导者的个人的职业生涯方面发挥了重要作用。 分子真菌学课程正在发展，以满足当前学生的需求。该课程已经开始了轮换领导的过程，以确保真菌社区内的广泛代表性和所有权，并在该领域的前沿新的实验和主题不断添加到课程。虽然分子真菌学课程在过去主要得到了几个资金来源的支持，包括学生学费，Burroughs Wellcome基金，霍华德休斯医学研究所，MBL教育办公室和各种制药公司，这些资金来源可能不足以维持和发展科学卓越，也不足以保持足够低的学生成本，使我们能够招募最有前途和多样化的班级当我们向前迈进。因此，该课程寻求与NIAID合作，以开发持续和充足的资金。有了这样的支持，MBL分子真菌学课程主任和教师将能够继续培养医学真菌学研究的下一代领导者，他们将有助于揭示真菌疾病的关键因素，并开发新的治疗和诊断工具用于管理人类真菌感染。 公共卫生相关性：海洋生物实验室的分子真菌学课程自14年前成立以来一直是医学真菌学研究界的重要资源。本课程的目标是培养医学真菌学研究的下一代领导者。这些科学家将领导该领域为危及生命的人类真菌感染开发新的治疗和诊断策略。