Strategies and Techniques for Analyzing Microbial Population Structures
分析微生物种群结构的策略和技术
基本信息
- 批准号:8734959
- 负责人:
- 金额:$ 11.4万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-09-15 至 2018-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressBioinformaticsBiologicalCommunitiesComplexComputer ArchitecturesComputer softwareComputersDNADNA SequenceDataData AnalysesData SetDevelopmentEcologyEducational workshopEquipment and supply inventoriesExerciseFacultyGenesGenomicsGoalsHealthHigh-Throughput DNA SequencingHumanHuman MicrobiomeInvestigationLaboratoriesLearningLibrariesLifeMarinesMassive Parallel SequencingMetabolicMetagenomicsMethodologyMetricMicrobeMolecularPersonal SatisfactionPopulationPostdoctoral FellowPreparationQuality ControlRNAResearchResearch PersonnelScheduleSeriesShotgunsStatistical ModelsStructureStudentsTechniquesTechnologyTimeTrainingUrsidae FamilyWood materialanalytical toolbasecostdesigngraduate studenthigh end computerlaptoplecturesmicrobialmicrobial communitynext generation sequencingnovelposterspublic health relevancetheoriestool
项目摘要
DESCRIPTION (provided by applicant): Strategies and Techniques for Analyzing Microbial Population Structures (STAMPS) - A workshop at the Marine Biological Laboratory in Woods Hole. This proposal describes a new, 10-day emersion course that will focus on design and analysis of marker gene and shotgun metagenomic projects for advanced graduate students, postdoctoral fellows and established investigators who seek to leverage the power of massively-parallel DNA sequencing technologies for investigations of microbial communities including the human microboime and host associated microbes. The format will include a series of lectures and computer laboratory exercises on the theory, application and experimental strategies for analysis of microbial communities through massively parallel, high-throughput DNA sequencing technology. Topics will include: current technologies for massively parallel sequencing (MPS) of DNA and RNA, experimental strategies for using MPS in studies of microbial communities, library preparation techniques, organization of next generation sequence data and associated meta-data, principles of quality control of sequence data, the theory of clustering sequences by similarity and rarefaction analyses, taxonomic assignments for high-throughput data, statistical models for estimating microbial diversity, microbial community comparison methodology and metrics, network analyses, and the annotation and interpretation of shotgun metagenomic data. Authors of analytical tools for analysis of marker gene and shotgun metagenomic data will challenge the students with tutorials that address real world problems that bear on human health and well- being. Using their laptops, students will gain access to the high-performance computer architecture in the Josephine Bay Paul Center at the MBL for analysis of large data sets. As importantly, this new course will promote a dialogue and exchange of ideas between experts who seek to guide the development of new analytical paradigms for the rapidly evolving field of molecular microbial ecology. Early in the course schedule, students will have the opportunity to present research posters in order to promote interactions with other students and with faculty who can offer advice about data analysis.
描述(由申请人提供):分析微生物种群结构的策略和技术(STAMPS)-伍兹霍尔海洋生物实验室的研讨会。该提案描述了一个新的,为期10天的再现课程,将侧重于设计和分析标记基因和鸟枪宏基因组项目,为高级研究生,博士后研究员和既定的研究人员寻求利用并行DNA测序技术的力量来调查微生物群落,包括人类微生物和宿主相关微生物。该格式将包括一系列讲座和计算机实验室练习的理论,应用和实验策略,通过大规模并行,高通量DNA测序技术分析微生物群落。主题将包括:当前的DNA和RNA大规模并行测序(MPS)技术、在微生物群落研究中使用MPS的实验策略、文库制备技术、下一代序列数据和相关元数据的组织、序列数据质量控制原则、通过相似性和稀疏性分析对序列进行聚类的理论、高通量数据的分类学分配,用于估计微生物多样性的统计模型、微生物群落比较方法和指标、网络分析以及鸟枪宏基因组数据的注释和解释。分析标记基因和鸟枪宏基因组数据的分析工具的作者将用教程挑战学生,这些教程解决了影响人类健康和福祉的真实的世界问题。使用他们的笔记本电脑,学生将获得访问的高性能计算机架构在约瑟芬湾保罗中心在MBL的大型数据集的分析。同样重要的是,这门新课程将促进专家之间的对话和思想交流,这些专家寻求为快速发展的分子微生物生态学领域指导新的分析范式的发展。在课程安排的早期,学生将有机会展示研究海报,以促进与其他学生和教师的互动,他们可以提供有关数据分析的建议。
项目成果
期刊论文数量(0)
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专利数量(0)
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WILLIAM S. REZNIKOFF其他文献
WILLIAM S. REZNIKOFF的其他文献
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{{ truncateString('WILLIAM S. REZNIKOFF', 18)}}的其他基金
Strategies and Techniques for Analyzing Microbial Population Structures
分析微生物种群结构的策略和技术
- 批准号:
8548735 - 财政年份:2013
- 资助金额:
$ 11.4万 - 项目类别:
Molecular Mycology: Current Approaches to Fungal Pathogenesis
分子真菌学:真菌发病机制的最新方法
- 批准号:
8203997 - 财政年份:2011
- 资助金额:
$ 11.4万 - 项目类别:
Microbial Diversity Course: Building Capacity for Human Microbiome Exploration
微生物多样性课程:人类微生物组探索能力建设
- 批准号:
8008563 - 财政年份:2010
- 资助金额:
$ 11.4万 - 项目类别:
Biology of the Inner Ear: Experimental and Analytical Approaches
内耳生物学:实验和分析方法
- 批准号:
8073974 - 财政年份:2009
- 资助金额:
$ 11.4万 - 项目类别:
Biology of the Inner Ear: Experimental and Analytical Approaches
内耳生物学:实验和分析方法
- 批准号:
8470154 - 财政年份:2009
- 资助金额:
$ 11.4万 - 项目类别:
Biology of the Inner Ear: Experimental and Analytical Approaches
内耳生物学:实验和分析方法
- 批准号:
7792370 - 财政年份:2009
- 资助金额:
$ 11.4万 - 项目类别:
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