Gene Regulatory Networks for Development

描述（由申请人提供）：本提案是为伍兹霍尔海洋生物实验室提供的关于基因调控网络发展主题的短期课程提供支持。本课程于2008年秋季首次由Eric Davidson博士（加州理工学院）和David McClay博士（杜克大学）组织和指导，从那时起每年都开设。本课程提供了理解开发的系统级方法的基本信息。它是专为生物学家谁有兴趣在更多的定量方向移动他们的研究，并为科学家从计算或物理背景谁希望获得专业知识的生物系统与重点发展。本课程提供一系列密集的教学讲座、讨论、粉笔讲座、实验室演示和研讨会互动，以推进转录因子功能原理、基因调控网络组织以及解决发展中系统级问题的方法。它包括实际的实验室演示，如果需要的话，可以亲自体验，将开发中的研究成果转化为系统级的概念和模型。学生们都参与项目，从给定的文献来源构建基因网络并捕获

DESCRIPTION (provided by applicant): This proposal is for support of a short course on the topic of gene regulatory networks in development offered at the Marine Biological Laboratory in Woods Hole. This course was first organized and directed by Dr. Eric Davidson (Caltech) and Dr. David McClay (Duke) in the fall of 2008 and has been offered each year since then. The course provides essential information of systems level approaches to understand development. It is designed for biologists who have an interest in moving their research in more quantitative directions, and for scientists from computational or physics backgrounds who wish to gain expertise in biological systems with a focus on development. The course provides an intense series of didactic lectures, discussions, chalk talks, laboratory demonstrations, and workshop interactions that advance the principles of transcription factor function, gene regulatory network organization, and approaches for addressing systems-level problems in development. It includes practical laboratory demonstrations, with hands on experience if desired, for transforming research results in development to systems level concepts and models. Students all participate in projects to construct gene networks from given literature sources and to capture these networks in the BioTapestry computational platform. Students have ranged from advanced graduate students and postdoctoral fellows to faculty in biology, computer science, physics, mathematics, and clinical sciences. Course faculty includes experts in genomics, molecular genetics, gene regulatory mechanisms, bioinformatics, computation and graphic design, and development.