Gene Regulatory Networks for Development

描述(由申请人提供)：这项建议是为了支持伍兹霍尔海洋生物实验室提供的关于基因调控网络发展主题的短期课程。该课程于2008年秋季由加州理工学院的Eric Davidson博士和杜克大学的David McClay博士首次组织和指导，此后每年都开设。本课程提供了解开发的系统级方法的基本信息。它是为有兴趣将他们的研究转向更定量的方向的生物学家，以及希望获得生物系统专业知识并专注于开发的具有计算或物理背景的科学家而设计的。这门课程提供了一系列密集的教学讲座、讨论、粉笔演讲、实验室演示和研讨会互动，以推进转录因子功能、基因调控网络组织的原则，以及解决开发中系统级问题的方法。它包括将开发中的研究成果转化为系统级概念和模型的实际实验室演示，如果需要，还可以亲身体验。所有学生都参与项目，从给定的文献来源构建基因网络并获取 这些网络都在BioTapestry计算平台上。学生的范围从高级研究生和博士后研究员到生物学、计算机科学、物理、数学和临床科学的教师。课程教师包括基因组学、分子遗传学、基因调控机制、生物信息学、计算和图形设计以及开发方面的专家。

DESCRIPTION (provided by applicant): This proposal is for support of a short course on the topic of gene regulatory networks in development offered at the Marine Biological Laboratory in Woods Hole. This course was first organized and directed by Dr. Eric Davidson (Caltech) and Dr. David McClay (Duke) in the fall of 2008 and has been offered each year since then. The course provides essential information of systems level approaches to understand development. It is designed for biologists who have an interest in moving their research in more quantitative directions, and for scientists from computational or physics backgrounds who wish to gain expertise in biological systems with a focus on development. The course provides an intense series of didactic lectures, discussions, chalk talks, laboratory demonstrations, and workshop interactions that advance the principles of transcription factor function, gene regulatory network organization, and approaches for addressing systems-level problems in development. It includes practical laboratory demonstrations, with hands on experience if desired, for transforming research results in development to systems level concepts and models. Students all participate in projects to construct gene networks from given literature sources and to capture these networks in the BioTapestry computational platform. Students have ranged from advanced graduate students and postdoctoral fellows to faculty in biology, computer science, physics, mathematics, and clinical sciences. Course faculty includes experts in genomics, molecular genetics, gene regulatory mechanisms, bioinformatics, computation and graphic design, and development.