Employing Magnetic Vestibular Stimulation (MVS) during Functional Imaging

在功能成像期间采用磁前庭刺激 (MVS)

• 批准号: 9126109
• 负责人: JEROME L ACKERMAN
• 金额: $ 26.44万
• 依托单位: MASSACHUSETTS EYE AND EAR INFIRMARY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-01 至 2018-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9126109
• 关键词: Address; Affect; Anatomy; Animals; Bilateral; Biological Assay; Brain; Brain imaging; Cardiovascular system; Darkness; Data; Disease; Environment; Equilibrium; Eye Movements; Functional Imaging; Functional Magnetic Resonance Imaging; Goals; Head; Human; Illusions; Image; Knowledge; Labyrinth; Lateral; Lead; MRI Scans; Magnetism; Measurable; Measures; Methods; Migraine; Motion; Motion Perception; Motion Sickness; Movement; Pathologic Nystagmus; Patients; Perception; Peripheral; Positioning Attribute; Procedures; Process; Psychometrics; Publishing; Regulation; Reporting; Research; Resolution; Rest; Rotation; Semicircular canal structure; Seminal; Stimulus; Testing; Variant; Vestibular loss; Visual; Yaws; arm; design; human study; human subject; magnetic field; otoconia; public health relevance; response; visual process; visual processing

 DESCRIPTION (provided by applicant): Functional magnetic resonance imaging (fMRI) is widely used to study brain activation with high spatial resolution. Recently, human studies have shown that the strong static magnetic field required for fMRI incidentally yields magnetic vestibular stimulation (MVS). These studies show that MVS: 1) is evoked by the static field, 2) does not require subject movement, and 3) does not depend upon magnetic field changes (e.g., dB/dt). These empirical findings suggest that magnetic vestibular stimulation (MVS) could affect a large number of fMRI studies, including resting state brain imaging, since MVS yields vestibular responses that vary with inner ear orientation relative to the magnetic field. Given the pervasive influence of vestibular stimuli - including influences on visual processing, cardiovascular regulation, equilibrium, and motion sickness - MVS could potentially contaminate a broad range of imaging studies. To address these concerns, we propose to develop a procedure to minimize the influences of MVS (Aim 1). Furthermore, once we can minimize the influences of MVS, we will also choose to employ MVS when desired (Aim 2). More specifically, our goal in Aim 1 is to develop a procedure to minimize the influence of MVS by measuring perception and nystagmus in a 7T magnet to find a range of head positions for each subject that yield no perceptible and minimal measurable MVS effects. To minimize the influence of variations in peripheral vestibular anatomy, we also propose to image the gross anatomy (e.g., semicircular canal orientation) of the vestibular periphery. To demonstrate that MVS impacts resting state activation and to demonstrate that we can minimize its influence, functional imaging will be performed with the head tilted into one of two positions - a position found to eliminate MVS-evoked perceptual illusions and minimize nystagmus and a second position that yields both perceptual illusions and nystagmus. After determining how to minimize MVS due to the static magnetic field in Aim 1, we propose to employ MVS evoked by the static magnetic field in Aim 2 to investigate why fMRI activation differs from normal for patients suffering from vestibular migraine (VM) - a disorder accompanied by abnormal processing of vestibular stimuli.

 描述（由申请人提供）：功能性磁共振成像（fMRI）广泛用于以高空间分辨率研究大脑激活。最近，人体研究表明，功能磁共振成像所需的强静磁场附带产生磁前庭刺激（MVS）。这些研究表明，MVS：1）由静态场诱发，2）不需要对象移动，以及3）不依赖于磁场变化（例如，dB/dt）。这些实证研究结果表明，磁前庭刺激（MVS）可能会影响大量的功能磁共振成像研究，包括静息态脑成像，因为MVS产生前庭反应，随着内耳方向相对于磁场而变化。鉴于 前庭刺激的普遍影响-包括对视觉处理、心血管调节、平衡和运动病的影响- MVS可能潜在地污染广泛的成像研究。为了解决这些问题，我们建议制定一个程序，以尽量减少MVS的影响（目标1）。此外，一旦我们可以最大限度地减少MVS的影响，我们也将选择在需要时使用MVS（目标2）。 更具体地说，我们在目标1中的目标是开发一种程序，通过测量7 T磁体中的感知和眼球震颤来最大限度地减少MVS的影响，从而为每名受试者找到一系列头部位置，这些位置不会产生可感知和最小可测量的MVS效应。为了最小化外周前庭解剖结构变化的影响，我们还建议对大体解剖结构进行成像（例如，半规管方向）的前庭周边。为了证明MVS影响静息状态激活并证明我们可以最大限度地减少其影响，将在头部倾斜到两个位置之一时进行功能成像-一个位置可以消除MVS诱发的知觉错觉并最大限度地减少眼球震颤，另一个位置可以产生知觉错觉和眼球震颤。在确定如何最大限度地减少MVS由于目标1中的静磁场，我们建议采用MVS诱发的静磁场在目标2调查为什么功能磁共振成像激活不同于正常的患者患有前庭偏头痛（VM）-伴随着异常处理前庭刺激的疾病。