Bone Quality Assessment with a Novel Three-Bore Magnet Extremity MRI Scanner

使用新型三孔磁铁肢体 MRI 扫描仪进行骨质量评估

• 批准号: 9885138
• 负责人: JEROME L ACKERMAN
• 金额: $ 49.89万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-01 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9885138
• 关键词: 3-Dimensional; Address; Age; American; Animals; Biological; Biological Markers; Bone Density; Bone Matrix; Calibration; Capital; Cessation of life; Chemicals; Clinic; Clinical Data; Clinical Research; Clinical Trials; Coupled; Data; Deformity; Development; Diagnosis; Diagnostic; Disease; Dual-Energy X-Ray Absorptiometry; Elderly; Funding; Future; Gender; Generations; Goals; Health; Health system; Human; Image; Imaging Techniques; Ionizing radiation; Joints; Knowledge; Laboratories; Leg; Limb structure; MRI Scans; Magnetic Resonance Imaging; Measurement; Measures; Metabolic Bone Diseases; Methodology; Methods; Minerals; Noise; Osteomalacia; Osteoporosis; Pain; Patients; Performance; Peripheral; Phosphorus; Physiologic pulse; Postmenopause; Protons; Public Health; RF coil; Radiation Dose Unit; Radiation exposure; Renal Osteodystrophy; Resolution; Safety; Scanning; Serum; Signal Transduction; Societies; Solid; Specimen; Suggestion; Technology; Testing; Time; United States; United States National Institutes of Health; Woman; Writing; accurate diagnosis; animal tissue; arm; base; bone; bone fragility; bone imaging; bone quality; cohort; cost; density; design; design and construction; diagnostic panel; economic cost; experimental study; fracture risk; fragility fracture; healthy volunteer; image reconstruction; imaging modality; metabolic abnormality assessment; mineralization; network architecture; novel; quantitative imaging; reconstruction; screening; skeletal; soft tissue; solid state; stem; technology development

Osteoporosis and related metabolic bone diseases are nearly universal problems associated with advanced age, particularly for postmenopausal women, expecting to cost society over $22 billion annually by 2020, and leading to 65,000 deaths each year stemming from bone fragility fractures. Recent studies have demonstrated that MRI may be of particular utility for addressing several factors related to bone quality that can only be measured with difficulty in patients. High spatial resolution MRI can be used to accurately characterize trabecular microarchitecture, and follow it with treatment, without the attendant ionizing radiation dose of DXA or CT. Solid state MRI can uniquely measure the organic bone matrix content noninvasively as well as the mineral. Proton (1H) solid state MRI has been used to measure bone matrix, while phosphorus (31P) solid state MRI has potential to accurately assess 3D bone mineral density. Combining these two measurements in a single simultaneous measurement could facilitate a more informative diagnostic for metabolic bone disease, especially if coupled with high spatial resolution 3D trabecular imaging. MRI is an expensive measurement, and not justified for screening for or diagnosing metabolic bone disease. However, if the cost of MRI could be drastically reduced, such measurements could become financially competitive with DXA while providing significantly increased diagnostic information content, and at the same time completely eliminating ionizing radiation exposure. In this project, we will develop the methodology of MRI characterization of metabolic bone disease using a unique dedicated inexpensive, compact, cryogen-free extremity MRI scanner designed and constructed in a previous NIH-funded project. Notably, the magnet of this scanner has been designed for comfortable and efficacious extremity scanning, and in particular contains three bores: a central bore that is the “active” bore in which the limb being scanned is inserted, and two peripheral “nonactive” bores that comfortably accept the leg not being scanned. Both the capital and operating costs of this scanner, as well as the clinic “real estate” it occupies, are drastically lower than for the typical whole body scanner. As of this writing, a second generation compact tiltable magnet with multiple openings may arrive in the PI's lab by the beginning of this project. The specific aims are: 1) Further the technical development of high spatial resolution 3D MRI of trabecular network architecture, and solid state proton and phosphorus MRI for quantitative bone mineral and matrix measurement; 2) Assess the quantitative accuracy of solid state MRI for these measurements in phantoms, animal tissues, and live animals; 3) Evaluate the repeatability and accuracy of high spatial resolution and solid state MRI scanning in healthy volunteer subjects; and 4) Carry out studies of metabolic bone disease patients and age- and gender-matched normals to make a preliminary assessment of the accuracy of MRI-based bone characterization, and to acquire statistical information that will permit the design of future clinical trials.

骨质疏松及相关的代谢性骨病几乎是老年痴呆症的普遍问题