Moving MRI: Imaging a Moving Body with a Moving MRI Magnet

移动 MRI：使用移动 MRI 磁体对移动的身体进行成像

• 批准号: 10007118
• 负责人: JEROME L ACKERMAN
• 金额: $ 85.41万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-12 至 2023-09-11
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10007118
• 关键词: 3-Dimensional; Address; Anatomy; Animals; Athletic; Automobile Driving; Autonomic nervous system; BRAIN initiative; Basic Science; Behavioral; Blood; Brain; Brain Diseases; Brain Mapping; Brain imaging; Cardiovascular system; Clinic; Clinical; Complex; Conflict (Psychology); Coupled; Cues; Development; Diagnosis; Disease; Electroencephalography; Engineering; Environment; Equilibrium; Eye; Feedback; Financial compensation; Fingers; Functional Imaging; Functional Magnetic Resonance Imaging; Functional disorder; Goals; Gymnastics; Hand; Head; Helium; Homeostasis; Human; Human Resources; Image; Imaging technology; Individual; Injury; Knowledge; Laboratories; Leg; Life; Light; Limb structure; Liquid substance; Locomotion; Loudness; Magnetic Resonance Imaging; Manuals; Manufactured Baseball; Maps; Measures; Methodology; Methods; Migraine; Modification; Morphologic artifacts; Motion; Motion Sickness; Motor; Movement; Muscle; Near-Infrared Spectroscopy; Nervous System Physiology; Nervous system structure; Neurology; Neurons; Neurosciences; Nitrogen; Patients; Performance; Perfusion; Physics; Physiologic pulse; Physiology; Pilot Projects; Planet Earth; Population; Positioning Attribute; Process; Psychological reinforcement; RF coil; Rattus; Regulation; Research; Research Methodology; Resolution; Rodent; Role; Rotation; Safety; Scheme; Sensory; Sensory-Somatic Nervous System; Series; Sprague-Dawley Rats; Stimulus; Surface; Symptoms; Synovial Fluid; System; Technology; Testing; Time; Tissues; Translations; Traumatic Brain Injury; Vision; Visual system structure; Work; active vision; anatomic imaging; arm; arm movement; brain tissue; cranium; experience; imaging modality; imaging system; improved; instrument; magnetic field; mind control; motor control; neuroimaging; neurological rehabilitation; new technology; novel; portability; prevent; prototype; relating to nervous system; response; robot control; signal processing; sound; virtual reality

In response to BRAIN RFA-EB-19-001 we propose to demonstrate a novel noninvasive brain imaging method, Moving MRI (mMRI). In mMRI, a high resolution, high field, superconducting MRI magnet moves such that the subject's head and body effectively remain stationary with respect to the magnet. (This is neither portable nor head-mounted MRI.) By eliminating the relative motion between head and magnet, massive motion artifacts are largely suppressed. Moving MRI would for the first time enable recording of high quality anatomic and functional images in subjects experiencing true motion stimulation (i.e., rotations, tilts, and translations). Neuronal activation associated with naturalistic stimulation of the vestibular system can thereby be revealed with functional MRI (fMRI). The three- dimensional deformation of brain tissue and fluid displacement may be mapped using displacement- and flow- sensitive MRI, with applications to traumatic brain injury (TBI) and aerospace physiology. Brain functional networks responding to vestibular stimuli might be studied to enhance our knowledge of vestibular physiology or to diagnose disorders such as vestibular migraine. Tissue deformation in response to motion might be studied safely, noninvasively and in real time, yielding accurate three-dimensional maps of tissue strain tensors, and blood and synovial fluid perfusion and flow. New superconducting magnet technology (cryogen-free magnets in which the main coil is conduction-cooled by an electrically powered cryocooler while eliminating the need for liquid helium or nitrogen) makes possible the construction of MRI magnets that can be safely tilted and moved while at field. Our laboratory has such a magnet, which has been tested to confirm its high field stability under conditions of dynamic tilt and translation. In this project, this magnet will be equipped with a simple motion platform to demonstrate the concept of mMRI. While vestibular testing in both the clinic and laboratory uses motion platforms, high spatial resolution imaging technologies for these motion applications do not exist. Although methodologies such as electroencephalography (EEG), which does not offer high spatial resolution, and functional near-infrared spectroscopy (fNIRS), which can image only the cortical surface, are established for human research, mMRI promises to introduce high quality information-rich imaging to the field of brain activation during motion. This could yield a singular advance for our understanding of brain activation during motion that could dramatically advance TBI research. The specific aims are: 1) Adapt an existing cryogen-free magnet so that it can be moved via a simple motion platform; 2) Demonstrate anatomic and functional mMRI in phantoms, and in a pilot study using live rats. Motion paradigms will include large-scale dynamic tilt and Earth-vertical rotation. The ultimate goal of this work is to lay the groundwork for the development of a human-scale mMRI scanner.

作为对BRAIN RFA-EB-19-001的回应，我们提出了一种新的非侵入性脑成像方法， 移动MRI（mMRI）。在mMRI中，高分辨率、高场、超导MRI磁体移动，使得磁共振成像系统中的磁共振成像系统中 对象的头部和身体相对于磁体有效地保持静止。(This既不便携， 头戴式MRI。）通过消除头部和磁铁之间的相对运动，产生大量运动伪影 在很大程度上被压制了。 移动MRI将首次能够记录受试者的高质量解剖和功能图像 经历真实的运动刺激（即，旋转、倾斜和平移）。神经元激活与 因此，前庭系统的自然刺激可以用功能性MRI（fMRI）来揭示。三个- 脑组织的尺寸变形和流体位移可以使用位移和流动来映射， 敏感的MRI，应用于创伤性脑损伤（TBI）和航空航天生理学。脑功能 可以研究对前庭刺激做出反应的网络，以增强我们对前庭生理学的了解 或诊断诸如前庭性偏头痛的疾病。运动引起的组织变形 安全、非侵入性和真实的时间研究，产生组织应变的精确三维图 张量以及血液和滑液灌注和流动。 新的超导磁体技术（无致冷剂磁体，其中主线圈是传导冷却的 通过电动低温冷却器，同时消除了对液氦或液氮的需要）使得 MRI磁体的结构，可以安全地倾斜和移动，而在外地。我们实验室就有这样一个 磁铁，已被测试，以确认其在动态倾斜和平移条件下的高场稳定性。 在这个项目中，这个磁铁将配备一个简单的运动平台来演示mMRI的概念。 虽然临床和实验室中的前庭测试都使用运动平台，但高空间分辨率成像 不存在用于这些运动应用的技术。尽管诸如 脑电图（EEG），它不提供高的空间分辨率，和功能性近红外 核磁共振波谱（fNIRS），它只能成像皮层表面，建立了人类的研究，mMRI 有望将高质量的信息丰富的成像引入运动期间的大脑激活领域。这 可以为我们理解运动中的大脑激活带来一个独特的进步， TBI研究进展 具体的目标是：1）改造现有的无致冷剂磁体，使其可以通过简单的运动来移动 2）在幻影中以及在使用活体大鼠的初步研究中展示解剖和功能mMRI。 运动范例将包括大规模的动态倾斜和地球垂直旋转。这项工作的最终目标 是为开发人类规模的核磁共振成像扫描仪奠定基础。