Harnessing Movement Variability to Treat and Prevent Motor Related Disorder

我们建议在内布拉斯加大学奥马哈分校建立一个生物医学研究卓越中心 这将创造基础设施和专业知识基础，以探索人类运动的机制 可变性，以治疗和预防运动相关疾病。这项建议涉及四个研究项目， 每个项目由一名初级教师领导，并由至少一名高级教师指导，该教师是 临床研究者。在项目1中，Myers博士建议确定临床评估指标。 使用步态变异性的外周疾病患者的决策。在项目2中，慕克吉博士将 研究提供自我运动感知的虚拟现实模拟是否会影响中风患者的步态变异性 幸存者这项研究将确定增强的视觉输入是否有助于消除感官冲突， 通常存在于GAT康复期间。在项目3中，乔博士将探讨老年人谁是在风险， 福尔斯将证明步态变异性的改善，接近健康年轻人在行走时的步态变异性。 与不变视觉刺激和随机视觉刺激相比，可变视觉刺激。短 以及三种刺激对步态变异性和自适应步态任务性能的长期影响， 研究了在项目4中，Kyvelidou博士将研究在典型的发展中国家之间是否存在差异。 婴儿和有自闭症风险的婴儿在发展中的姿势摇摆变异性和凝视行为， 第一年以及它们与后来诊断的关系。这些信息可以让 发展自闭症的早期检测模式和基础知识的进步 由此可以开发出治疗自闭症的方法。一个强大的指导计划是为初级建立 调查员，使他们能够实现成功的独立职业生涯。该中心建立在现有的 研究人体运动变化的专业知识，并利用一个新的专用建筑与国家的最先进的 实验室展示了强大的机构支持。这种COBRE将通过增加 新项目和调查人员。其结果将是一个持续的，自我维持的，有竞争力的研究 中心，将改变研究文化，并刺激卓越的UNO和整个内布拉斯加州。

We propose to establish a center of biomedical research excellence at the University of Nebraska Omaha that will create the infrastructure and expertise base to explore the mechanisms of human movement variability in order to treat and prevent motor related disorders. This proposal involves four research projects, each lead by a junior faculty member who will be mentored by at least one senior faculty member who is an established clinical investigator. In Project 1, Dr. Myers proposes to identify an assessment metric for clinical decision making in patients with peripheral disease using gait variability. In Project 2, Dr. Mukherjee will investigate if Virtual Reality simulations providing perception of self-motion influence gait variability in stroke survivors. This research will identify if augmented visual inputs can help to remove sensory conflicts that commonly exist during gat rehabilitation. In Project 3, Dr. Qiao will explore if older adults who are at risk of falls will demonstrate improvements in gait variability that approach that of healthy young when walking with a variable visual stimulus, compared to an invariant visual stimulus and a random visual stimulus. The short and long-term effects of the three stimuli on gait variability and performance of adaptive gait tasks will be investigated. In Project 4, Dr. Kyvelidou will investigate if differences exist between typically developing infants and infants at risk for autism in terms of developing postural sway variability and gaze behavior in the first year as well as their relationship to later presence of diagnosis. This information could allow the development of an early detection paradigm for autism and the advancement of foundational knowledge from which treatments for autism may be developed. A strong mentoring program is established for the junior investigators, enabling them to achieve successful independent careers. This Center builds on existing expertise on the study of human movement variability and utilizes a new dedicated building with state-of-the-art laboratories demonstrating strong institutional support. This COBRE will be perpetuated by the addition of new projects and investigators. The result will be a continuing, self-sustaining, and competitive research Center that will transform the research culture and stimulate excellence in UNO and throughout Nebraska.