Harnessing Movement Variability to Treat and Prevent Motor Related Disorders

项目总结 在科布雷第一阶段，我们建立了人类运动可变性研究中心 (MOVCENTR)允许发展强大的临界群体的调查人员和 拥有世界一流设施和资源的研究基础设施的巨大增长 如生物力学研究大楼及其相关技术和 方法论以及大楼即将进行的扩建。在科布雷第二阶段，我们在 这些基础性的成功最大限度地实现了独立、 可持续的、专题的、跨学科的中心。我们致力于进一步加强基础设施 和专业知识基础，以探索人类运动可变性的机制，以便治疗 并预防与运动相关的疾病。因此，我们建议建立三个新的研究 型芯，运动分析型芯，非线性分析型芯，加工和 原型核心。我们的目标也是扩大资助调查人员支持的临界质量 研究人类运动的可变性。因此，我们提出了四个研究项目，这些项目将 在该中心的保护伞下进行。项目名称为：(1)假体的影响 用于皮质激活和运动可变性，(2)步态可变性的纵向研究 预测帕金森病跌倒，(3)外骨骼优化减少步态变异性 外周动脉疾病患者；(4)反应稳定的变异性和特异性 移动到不同的滑移扰动。这些项目由实力雄厚的初级调查人员领导 与美国国立卫生研究院资助的资深临床科学家一起担任科学顾问。这样的指导 这种关系是独一无二的，并在提高效率和质量方面发挥了很好的作用 在我们主题下的每个研究项目中进行的临床和转化性研究 科学聚焦。

PROJECT SUMMARY In COBRE Phase I we established the Center for Research in Human Movement Variability (MOVCENTR) allowing the development of a strong critical mass of investigators and tremendous growth in terms of research infrastructure with world class facilities and resources such as the Biomechanics Research Building with its associated technologies and methodologies as well as the building’s upcoming expansion. In COBRE Phase II, we build on these foundational successes to maximize the likelihood of achieving an independent, sustainable, thematic, interdisciplinary center. We aim to further strengthen the infrastructure and expertise base to explore the mechanisms of human movement variability in order to treat and prevent motor related disorders. Therefore, we propose to establish three new research cores, the Movement Analysis Core, the Nonlinear Analysis Core, and the Machining and Prototyping Core. We also aim to expand the critical mass of funded investigators supporting research in human movement variability. As such we propose four research projects that will be carried out under the Center’s umbrella. The project titles are: (1) The influence of prosthesis use on cortical activation and movement variability, (2) Longitudinal study of gait variability to predict falls in Parkinson disease, (3) Exoskeleton optimization for reducing gait variability in patients with Peripheral Artery Disease, and (4) Variability and specificity in reactive stabilization movements to diverse slip perturbations. These projects are led by strong junior investigators paired with senior clinical NIH-funded scientists as scientific advisors. Such a mentoring relationship is unique and has worked very well in enhancing the efficiency and quality of the clinical and translational research that is conducted in each research project under our thematic scientific focus.