Harnessing Movement Variability to Treat and Prevent Motor Related Disorders

利用运动变异性来治疗和预防运动相关疾病

• 批准号: 10004062
• 负责人: NIKOLAOS STERGIOU
• 金额: $ 211.99万
• 依托单位: UNIVERSITY OF NEBRASKA OMAHA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10004062
• 关键词: Achievement; Address; Award; Behavioral; Biology; Biomechanics; Biomedical Engineering; Biomedical Research; Centers of Research Excellence; Clinical; Clinical Investigator; Clinical Research; Core Facility; Development; Disease; Enrollment; Faculty; Foundations; Funding; Gait; Generations; Goals; Growth; Home environment; Human; Infrastructure; Institution; Intervention; Investigation; Joints; Laboratories; Longitudinal Studies; Mentors; Methodology; Motor; Movement; Nebraska; Neurologic; Noise; Parkinson Disease; Patients; Peripheral arterial disease; Phase; Pilot Projects; Positioning Attribute; Posture; Process; Prosthesis; Rehabilitation therapy; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Scientist; Source; Specificity; System; Technology; Time; Training; Translating; Translational Research; United States National Institutes of Health; Universities; Work; base; exoskeleton; falls; graduate student; innovation; interdisciplinary approach; member; movement analysis; neurobehavioral; neuromuscular system; prevent; professor; prototype; restoration; skeletal; success; translational scientist; undergraduate student

PROJECT SUMMARY In COBRE Phase I we established the Center for Research in Human Movement Variability (MOVCENTR) allowing the development of a strong critical mass of investigators and tremendous growth in terms of research infrastructure with world class facilities and resources such as the Biomechanics Research Building with its associated technologies and methodologies as well as the building’s upcoming expansion. In COBRE Phase II, we build on these foundational successes to maximize the likelihood of achieving an independent, sustainable, thematic, interdisciplinary center. We aim to further strengthen the infrastructure and expertise base to explore the mechanisms of human movement variability in order to treat and prevent motor related disorders. Therefore, we propose to establish three new research cores, the Movement Analysis Core, the Nonlinear Analysis Core, and the Machining and Prototyping Core. We also aim to expand the critical mass of funded investigators supporting research in human movement variability. As such we propose four research projects that will be carried out under the Center’s umbrella. The project titles are: (1) The influence of prosthesis use on cortical activation and movement variability, (2) Longitudinal study of gait variability to predict falls in Parkinson disease, (3) Exoskeleton optimization for reducing gait variability in patients with Peripheral Artery Disease, and (4) Variability and specificity in reactive stabilization movements to diverse slip perturbations. These projects are led by strong junior investigators paired with senior clinical NIH-funded scientists as scientific advisors. Such a mentoring relationship is unique and has worked very well in enhancing the efficiency and quality of the clinical and translational research that is conducted in each research project under our thematic scientific focus.

项目概要 在 COBRE 第一阶段，我们建立了人体运动变异性研究中心 （MOVCENTR）允许培养强大的关键调查人员和 研究基础设施的巨大增长，拥有世界一流的设施和资源 例如生物力学研究大楼及其相关技术和 方法以及该建筑即将进行的扩建。在 COBRE 第二阶段，我们建立在 这些基础性的成功最大限度地提高了实现独立、 可持续、专题、跨学科中心。我们的目标是进一步加强基础设施 和专业知识基础来探索人体运动变异的机制，以治疗 并预防运动相关疾病。因此，我们建议建立三个新的研究 核心、运动分析核心、非线性分析核心以及加工和 原型设计核心。我们还旨在扩大受资助的研究人员的临界数量，以支持 人类运动变异性的研究。因此，我们提出了四个研究项目 在该中心的保护下进行。项目名称为：（1）假肢的影响 用于皮层激活和运动变异性，（2）步态变异性的纵向研究 预测帕金森病跌倒，(3) 外骨骼优化以减少步态变异 患有外周动脉疾病的患者，以及（4）反应稳定的变异性和特异性 各种滑移扰动的运动。这些项目由实力雄厚的初级研究人员领导 与 NIH 资助的高级临床科学家配对作为科学顾问。这样的辅导 这种关系是独一无二的，并且在提高效率和质量方面发挥了很好的作用。 在我们的主题下的每个研究项目中进行的临床和转化研究 科学聚焦。