Harnessing Movement Variability to Treat and Prevent Motor Related Disorders

项目摘要 在COBRE第一阶段，我们建立了人类运动可变性研究中心 （MOVCENTR），从而能够发展强大的调查员临界质量， 在拥有世界一流设施和资源的研究基础设施方面的巨大增长 如生物力学研究大楼及其相关技术， 方法以及建筑物即将进行的扩建。在COBRE第二阶段， 这些基本的成功，以最大限度地实现独立的， 可持续的、主题性的、跨学科的中心。我们的目标是进一步加强基础设施 和专业知识基础，探索人体运动变异的机制，以治疗 并预防运动相关疾病。因此，我们建议建立三个新的研究 核心，运动分析核心，非线性分析核心，加工和 原型核心。我们还旨在扩大资助调查人员的临界质量， 人体运动变异性的研究因此，我们提出了四个研究项目， 在中心的保护伞下进行。本课题的题目是：（1）假肢对人体的影响 使用皮层激活和运动变异，（2）步态变异的纵向研究， 预测帕金森病中的福尔斯，（3）用于减少帕金森病患者步态变异性的外骨骼优化， 外周动脉疾病患者，以及（4）反应稳定性的变异性和特异性 运动到不同的滑动扰动。这些项目由实力雄厚的初级调查员领导 与NIH资助的高级临床科学家作为科学顾问配对。这样的指导 这种关系是独一无二的，在提高 在我们的主题下，每个研究项目中进行的临床和转化研究 科学聚焦。

PROJECT SUMMARY In COBRE Phase I we established the Center for Research in Human Movement Variability (MOVCENTR) allowing the development of a strong critical mass of investigators and tremendous growth in terms of research infrastructure with world class facilities and resources such as the Biomechanics Research Building with its associated technologies and methodologies as well as the building’s upcoming expansion. In COBRE Phase II, we build on these foundational successes to maximize the likelihood of achieving an independent, sustainable, thematic, interdisciplinary center. We aim to further strengthen the infrastructure and expertise base to explore the mechanisms of human movement variability in order to treat and prevent motor related disorders. Therefore, we propose to establish three new research cores, the Movement Analysis Core, the Nonlinear Analysis Core, and the Machining and Prototyping Core. We also aim to expand the critical mass of funded investigators supporting research in human movement variability. As such we propose four research projects that will be carried out under the Center’s umbrella. The project titles are: (1) The influence of prosthesis use on cortical activation and movement variability, (2) Longitudinal study of gait variability to predict falls in Parkinson disease, (3) Exoskeleton optimization for reducing gait variability in patients with Peripheral Artery Disease, and (4) Variability and specificity in reactive stabilization movements to diverse slip perturbations. These projects are led by strong junior investigators paired with senior clinical NIH-funded scientists as scientific advisors. Such a mentoring relationship is unique and has worked very well in enhancing the efficiency and quality of the clinical and translational research that is conducted in each research project under our thematic scientific focus.