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Harnessing Movement Variability to Treat and Prevent Motor Related Disorders

利用运动变异性来治疗和预防运动相关疾病

基本信息

批准号：
10245007
负责人：
NIKOLAOS STERGIOU
金额：
$ 207.05万
依托单位：
UNIVERSITY OF NEBRASKA OMAHA
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10245007
关键词：
Achievement Address Award Behavioral Biology Biomechanics Biomedical Engineering Biomedical Research Centers of Research Excellence Clinical Clinical Investigator Clinical Research Core Facility Development Disease Enrollment Faculty Foundations Funding Gait Generations Goals Growth Home Human Infrastructure Institution Intervention Investigation Joints Laboratories Longitudinal Studies Mentors Methodology Motor Movement Nebraska Neurologic Noise Parkinson Disease Patients Peripheral arterial disease Phase Pilot Projects Positioning Attribute Posture Process Prosthesis Rehabilitation therapy Research Research Infrastructure Research Personnel Research Project Grants Research Support Resources Scientist Source Specificity System Technology Time Training Translating Translational Research United States National Institutes of Health Universities Work base exoskeleton falls graduate student innovation interdisciplinary approach member movement analysis neurobehavioral neuromuscular system prevent professor prototype restoration skeletal success translational scientist undergraduate student

项目摘要

PROJECT SUMMARY In COBRE Phase I we established the Center for Research in Human Movement Variability (MOVCENTR) allowing the development of a strong critical mass of investigators and tremendous growth in terms of research infrastructure with world class facilities and resources such as the Biomechanics Research Building with its associated technologies and methodologies as well as the building’s upcoming expansion. In COBRE Phase II, we build on these foundational successes to maximize the likelihood of achieving an independent, sustainable, thematic, interdisciplinary center. We aim to further strengthen the infrastructure and expertise base to explore the mechanisms of human movement variability in order to treat and prevent motor related disorders. Therefore, we propose to establish three new research cores, the Movement Analysis Core, the Nonlinear Analysis Core, and the Machining and Prototyping Core. We also aim to expand the critical mass of funded investigators supporting research in human movement variability. As such we propose four research projects that will be carried out under the Center’s umbrella. The project titles are: (1) The influence of prosthesis use on cortical activation and movement variability, (2) Longitudinal study of gait variability to predict falls in Parkinson disease, (3) Exoskeleton optimization for reducing gait variability in patients with Peripheral Artery Disease, and (4) Variability and specificity in reactive stabilization movements to diverse slip perturbations. These projects are led by strong junior investigators paired with senior clinical NIH-funded scientists as scientific advisors. Such a mentoring relationship is unique and has worked very well in enhancing the efficiency and quality of the clinical and translational research that is conducted in each research project under our thematic scientific focus.

项目总结