Harnessing Movement Variability to Treat and Prevent Motor Related Disorder

利用运动变异性来治疗和预防运动相关疾病

• 批准号: 8902214
• 负责人: NIKOLAOS STERGIOU
• 金额: $ 203.43万
• 依托单位: UNIVERSITY OF NEBRASKA OMAHA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8902214
• 关键词: Harnessing; Movement; Variability; Treat; Prevent

DESCRIPTION (provided by applicant): We propose to establish a center of biomedical research excellence at the University of Nebraska Omaha that will create the infrastructure and expertise base to explore the mechanisms of human movement variability in order to treat and prevent motor related disorders. This proposal involves four research projects, each lead by a junior faculty member who will be mentored by at least one senior faculty member who is an established clinical investigator. In Project 1, Dr. Myers proposes to identify an assessment metric for clinical decision making in patients with peripheral disease using gait variability. In Project 2, Dr. Mukherjee will investigate if Virtual Reality simulations providing perception of self-motion influence gait variability in stroke survivors. This research will identify if augmente visual inputs can help to remove sensory conflicts that commonly exist during gat rehabilitation. In Project 3, Dr. Qiao will explore if older adults who are at risk of falls will demonstrate improvements in gait variability that approach that of healthy young when walking with a variable visual stimulus, compared to an invariant visual stimulus and a random visual stimulus. The short and long-term effects of the three stimuli on gait variability and performance of adaptive gait tasks will be investigated. In Project 4, Dr. Kyvelidou will investigate if differencs exist between typically developing infants and infants at risk for autism in terms of developing postural sway variability and gaze behavior in the first year as well as their relationship to late presence of diagnosis. This information could allow the development of an early detection paradigm for autism and the advancement of foundational knowledge from which treatments for autism may be developed. A strong mentoring program is established for the junior investigators, enabling them to achieve successful independent careers. This Center builds on existing expertise on the study of human movement variability and utilizes a new dedicated building with state of-the art laboratories demonstrating strong institutional support. This COBRE will be perpetuated by the addition of new projects and investigators. The result will be a continuing, self-sustaining, and competitive research Center that will transform the research culture and stimulate excellence in UNO and throughout Nebraska. PUBLIC HEALTH RELANCE: Human movement variability has been largely ignored as a source of important clinical information and has been treated as noise and error in the motor system. However, altered human movement variability is found increasingly in a variety of motor related disorders indicating reduced adaptive capacity in the neuromuscular system. The scientists in this Center will determine optimal approaches for therapies grounded on the restoration of variability and complexity of movement that could be applied across a range of diseases

描述（由申请人提供）：我们建议在内布拉斯加大学奥马哈分校建立一个卓越的生物医学研究中心，该中心将创建基础设施和专业知识基础，以探索人类运动变异性的机制，以治疗和预防运动相关疾病。该提案涉及四个研究项目，每个项目由一名初级教师领导，他们将由至少一名资深教师指导，该教师是一名成熟的临床研究者。在项目1中，Myers博士建议使用步态变异性确定外周疾病患者临床决策的评估指标。在项目2中，Mukherjee博士将研究提供自我运动感知的虚拟现实模拟是否会影响中风幸存者的步态变异性。这项研究将确定是否增强视觉输入可以帮助消除在gat康复过程中普遍存在的感觉冲突。在项目3中，乔博士将探索与不变视觉刺激和随机视觉刺激相比，有福尔斯风险的老年人在行走时的步态变异性是否会得到改善，接近健康年轻人。将研究这三种刺激对步态变异性和自适应步态任务性能的短期和长期影响。在项目4中，Kyvelidou博士将研究在第一年发展姿势摇摆变异性和凝视行为方面，正常发育的婴儿和有自闭症风险的婴儿之间是否存在差异，以及它们与晚期诊断的关系。这些信息可以帮助开发自闭症的早期检测范式，并促进基础知识的发展，从而开发自闭症的治疗方法。为初级调查员建立了一个强有力的指导方案，使他们能够实现成功的独立职业生涯。该中心建立在现有的人类运动变异性研究的专业知识，并利用一个新的专用建筑与国家的最先进的实验室展示强大的机构支持。COBRE将通过增加新的项目和调查人员来延续。其结果将是一个持续的，自我维持的和有竞争力的研究中心，将改变研究文化，并刺激卓越的UNO和整个内布拉斯加州。 公共卫生保健：人体运动变异性作为重要的临床信息来源在很大程度上被忽视，并被视为运动系统中的噪声和错误。然而，在各种运动相关疾病中越来越多地发现改变的人类运动变异性，这表明神经肌肉系统的适应能力降低。该中心的科学家将确定基于恢复运动的可变性和复杂性的最佳治疗方法，这些方法可以应用于一系列疾病