Harnessing Movement Variability to Treat and Prevent Motor Related Disorder

描述(申请人提供)：我们建议在内布拉斯加州奥马哈大学建立一个生物医学研究卓越中心，该中心将创建基础设施和专业知识基础，以探索人类运动可变性的机制，以治疗和预防运动相关疾病。这项提案涉及四个研究项目，每个项目由一名初级教员领导，该教员将至少由一名资深教员指导，该教员是一名成熟的临床研究员。在项目1中，迈尔斯博士建议使用步态变异性为周围性疾病患者的临床决策确定一个评估指标。在项目2中，慕克吉博士将研究提供自我运动感知的虚拟现实模拟是否会影响中风幸存者的步态可变性。这项研究将确定增强视觉输入是否有助于消除在GAT康复过程中普遍存在的感觉冲突。在项目3中，乔博士将探索，与不变的视觉刺激和随机的视觉刺激相比，有跌倒风险的老年人是否会表现出步态可变性的改善，与不变的视觉刺激和随机的视觉刺激相比，步态可变性接近健康年轻人。将研究这三种刺激对步态可变性和自适应步态任务性能的短期和长期影响。在项目4中，Kyvelidou博士将调查发育正常的婴儿和有自闭症风险的婴儿在第一年的姿势摆动变异性和凝视行为方面是否存在差异，以及它们与确诊时间较晚的关系。这些信息可以使自闭症早期检测范例的发展和基础知识的进步，从而可以开发自闭症的治疗方法。为初级调查人员建立了强大的指导计划，使他们能够实现成功的独立职业生涯。该中心建立在研究人体运动可变性的现有专业知识的基础上，并利用一座新的专用建筑，该建筑拥有最先进的实验室，展示了强有力的机构支持。这个科布雷将通过增加新的项目和调查人员而永久存在。其结果将是一个持续的、自我维持的和具有竞争力的研究中心，它将改变研究文化，并在联合国大学和整个内布拉斯加州促进卓越。 与公共卫生有关：人类运动的可变性作为重要临床信息的来源在很大程度上被忽视了，并被视为运动系统中的噪音和误差。然而，在各种与运动相关的疾病中，越来越多地发现人类运动可变性的改变，表明神经肌肉系统的适应能力降低。该中心的科学家将根据运动的可变性和复杂性的恢复来确定最佳的治疗方法，这些方法可以应用于一系列疾病

DESCRIPTION (provided by applicant): We propose to establish a center of biomedical research excellence at the University of Nebraska Omaha that will create the infrastructure and expertise base to explore the mechanisms of human movement variability in order to treat and prevent motor related disorders. This proposal involves four research projects, each lead by a junior faculty member who will be mentored by at least one senior faculty member who is an established clinical investigator. In Project 1, Dr. Myers proposes to identify an assessment metric for clinical decision making in patients with peripheral disease using gait variability. In Project 2, Dr. Mukherjee will investigate if Virtual Reality simulations providing perception of self-motion influence gait variability in stroke survivors. This research will identify if augmente visual inputs can help to remove sensory conflicts that commonly exist during gat rehabilitation. In Project 3, Dr. Qiao will explore if older adults who are at risk of falls will demonstrate improvements in gait variability that approach that of healthy young when walking with a variable visual stimulus, compared to an invariant visual stimulus and a random visual stimulus. The short and long-term effects of the three stimuli on gait variability and performance of adaptive gait tasks will be investigated. In Project 4, Dr. Kyvelidou will investigate if differencs exist between typically developing infants and infants at risk for autism in terms of developing postural sway variability and gaze behavior in the first year as well as their relationship to late presence of diagnosis. This information could allow the development of an early detection paradigm for autism and the advancement of foundational knowledge from which treatments for autism may be developed. A strong mentoring program is established for the junior investigators, enabling them to achieve successful independent careers. This Center builds on existing expertise on the study of human movement variability and utilizes a new dedicated building with state of-the art laboratories demonstrating strong institutional support. This COBRE will be perpetuated by the addition of new projects and investigators. The result will be a continuing, self-sustaining, and competitive research Center that will transform the research culture and stimulate excellence in UNO and throughout Nebraska. PUBLIC HEALTH RELANCE: Human movement variability has been largely ignored as a source of important clinical information and has been treated as noise and error in the motor system. However, altered human movement variability is found increasingly in a variety of motor related disorders indicating reduced adaptive capacity in the neuromuscular system. The scientists in this Center will determine optimal approaches for therapies grounded on the restoration of variability and complexity of movement that could be applied across a range of diseases