Lab on a chip point of care assay for the rapid serodiagnosis of Lyme disease
用于莱姆病快速血清诊断的芯片即时检测实验室
基本信息
- 批准号:9052111
- 负责人:
- 金额:$ 100万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-09-03 至 2018-04-30
- 项目状态:已结题
- 来源:
- 关键词:AffectAftercareAlgorithmsAntibioticsAntibodiesAntigensAreaArthritisBedside TestingsBiological AssayBiological MarkersBloodBlood VolumeBorrelia burgdorferiCaringCenters for Disease Control and Prevention (U.S.)CollaborationsDataDetectionDevelopmentDevicesDiagnosisDiagnosticDiagnostic testsDiseaseDisease OutcomeDisease ProgressionEarly DiagnosisEarly treatmentEnzyme-Linked Immunosorbent AssayExtramural ActivitiesFingersHealthHeartHumanIn VitroInjuryJointsLaboratoriesLeadLettersLyme DiseaseMicrofluidicsNervous system structurePhaseRefractoryReproducibilityRunningSensitivity and SpecificitySerodiagnosesSerologicalSerumSkinStagingSymptomsSyndromeSystemTechnologyTestingTimeUnited StatesValidationVector-transmitted infectious diseasebasebody systemcostcross reactivitydesignimprovedmicro-total analysis systemoutcome forecastperformance testspoint of carepolypeptidepreventprototypestandard of carevalidation studies
项目摘要
DESCRIPTION: Caused by Borrelia burgdorferi, Lyme disease (LD) can affect the skin, heart, joints or nervous system leading to an array of largely non-specific symptoms that overlap with those of other debilitating illnesses. Disease progression can lead to development of conditions with unfavorable prognosis such as antibiotic-refractory arthritis or Post- Treatment Lyme disease Syndrome (PTLDS). Early diagnosis and treatment is key to improving disease outcomes. Current assays do not discriminate between early and late stages of the disease and cannot predict prognosis. We propose to use ultrasensitive microfluidics technology to develop the first quantitative rapid lab-on-a-chip point of care (POC) assay for the serodiagnosis of Lyme disease. The proposed POC test will provide sensitive and definitive detection and differentiation of early- and late- stage Lyme disease in a single test. It is a versatile and informative first-tier assay which can evolve to replace the current bi-serologic two-tier standard
of care.
产品说明:莱姆病(LD)由伯氏疏螺旋体引起,可以影响皮肤,心脏,关节或神经系统,导致一系列与其他衰弱性疾病重叠的非特异性症状。疾病进展可导致具有不利预后的病症的发展,例如难治性关节炎或治疗后莱姆病综合征(PTLDS)。早期诊断和治疗是改善疾病结局的关键。目前的检测方法不能区分疾病的早期和晚期,也不能预测预后。我们建议使用超灵敏的微流体技术来开发第一个定量的快速芯片实验室护理点(POC)检测,用于莱姆病的血清诊断。拟议的POC测试将提供敏感和明确的检测和区分早期和晚期莱姆病在一个单一的测试。它是一种通用的、信息丰富的一级检测试剂盒,可发展为替代当前的双血清学两级标准品
照顾。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Borrelia burgdorferi BBI39 Paralogs, Targets of Protective Immunity, Reduce Pathogen Persistence Either in Hosts or in the Vector.
伯氏疏螺旋体 BBI39 旁系同源物是保护性免疫的目标,可减少宿主或载体中病原体的持续存在。
- DOI:10.1093/infdis/jix036
- 发表时间:2017
- 期刊:
- 影响因子:0
- 作者:Singh,Preeti;Verma,Deepshikha;Backstedt,BrianT;Kaur,Simarjot;Kumar,Manish;Smith,AlexisA;Sharma,Kavita;Yang,Xiuli;Azevedo,JoséF;Gomes-Solecki,Maria;Buyuktanir,Ozlem;Pal,Utpal
- 通讯作者:Pal,Utpal
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Maria Gomes-Solecki其他文献
Maria Gomes-Solecki的其他文献
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{{ truncateString('Maria Gomes-Solecki', 18)}}的其他基金
ImmunoPET Probes for the Imaging of Lyme Disease
用于莱姆病成像的免疫PET探针
- 批准号:
10802275 - 财政年份:2023
- 资助金额:
$ 100万 - 项目类别:
Antibody isotyping for discrimination of disease stage and diagnosis of early Lyme disease.
用于区分疾病阶段和诊断早期莱姆病的抗体同种型。
- 批准号:
10080461 - 财政年份:2020
- 资助金额:
$ 100万 - 项目类别:
Antibody isotyping for discrimination of disease stage and diagnosis of early Lyme disease.
用于区分疾病阶段和诊断早期莱姆病的抗体同种型。
- 批准号:
10204992 - 财政年份:2020
- 资助金额:
$ 100万 - 项目类别:
Field trial and modeling of transmission blocking vaccine to prevent Lyme disease
预防莱姆病的传播阻断疫苗的现场试验和建模
- 批准号:
10159849 - 财政年份:2019
- 资助金额:
$ 100万 - 项目类别:
Field trial and modeling of transmission blocking vaccine to prevent Lyme disease
预防莱姆病的传播阻断疫苗的现场试验和建模
- 批准号:
9815231 - 财政年份:2019
- 资助金额:
$ 100万 - 项目类别:
Field trial and modeling of transmission blocking vaccine to prevent Lyme disease
预防莱姆病的传播阻断疫苗的现场试验和建模
- 批准号:
10636945 - 财政年份:2019
- 资助金额:
$ 100万 - 项目类别:
Field trial and modeling of transmission blocking vaccine to prevent Lyme disease
预防莱姆病的传播阻断疫苗的现场试验和建模
- 批准号:
10415156 - 财政年份:2019
- 资助金额:
$ 100万 - 项目类别:
Lab on a chip point of care assay for the rapid serodiagnosis of Lyme disease
用于莱姆病快速血清诊断的芯片即时检测实验室
- 批准号:
8195733 - 财政年份:2011
- 资助金额:
$ 100万 - 项目类别:
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