Epidemiology and Outcomes of HIV-associated Cancer

HIV 相关癌症的流行病学和结果

• 批准号: 9297960
• 负责人: Lifang Hou
• 金额: $ 10.04万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-09 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9297960
• 关键词: AIDS prevention; Acquired Immunodeficiency Syndrome; Adult; Africa; Africa South of the Sahara; Aging; Anti-Retroviral Agents; Area; Caring; Child; Clinical Trials; Collaborations; Country; Disease; Distance Learning; Doctor of Philosophy; Educational workshop; Emergency Situation; Epidemic; Epidemiology; Funding; Goals; Grant; HIV; Health; Health Priorities; Incidence; Institution; Interdisciplinary Study; International AIDS; Intervention; Kaposi Sarcoma; Laboratory Research; Lead; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Medical Education; Medical Research; Mentorship; Morbidity - disease rate; Nigeria; Non-Hodgkin' s Lymphoma; Oncogenic; Outcome; Pathogenesis; Pathology; Population; Provider; Research; Research Personnel; Research Project Grants; Research Training; Scientist; Teaching Hospitals; Time; Training; Training Programs; Translational Research; United States; Universities; Viral; base; cancer epidemiology; co-infection; experience; improved; innovation; mortality; novel; oncology; programs; translational clinical trial; treatment program; virology

DESCRIPTION (provided by applicant): AIDS malignancies are a serious problem in sub-Saharan Africa because of the widespread HIV epidemic and a high burden of oncogenic viral co-infections. Antiretroviral treatment programs put into place by PEPFAR, the Global Fund and others, have resulted in a remarkable decrease in HIV-related morbidity and mortality, however, the rate of malignancies and other non-communicable diseases is rising while at the same time, the population is aging. Most medical and research institutions in Africa are ill prepared to deal with these emerging health challenges. The University of Jos and Jos University Teaching Hospital (JUTH) HIV Care and Treatment Program, established in 2002, currently provides care, treatment and support to over 20,000 HIV- infected adults and children. This university-based center is one of the largest providers of HIV care in Africa. In an effort to improve the management of AIDS-associated malignancies in West Africa and the continent, University of Jos/JUTH in conjunction with Northwestern University, proposes to build a multidisciplinary research-training program, which will build upon collaborations and enhance capacity in Nigeria by developing research teams focused on innovative collaborative endeavors in AIDS-defining malignancies (cervical cancer, Kaposi sarcoma, and non-Hodgkin lymphoma). Our primary hypothesis is that building capacity in cancer epidemiology, clinical trials, translational, and laboratory research on AIDS-defining malignancies will lead to a significant reduction in incidence and related morbidity and mortality. We will build on existing in-country training capacity provided by the United States President's Emergency Program for AIDS Relief (PEPFAR), Northwestern University AIDS International Training and Research Program (Northwestern-AITRP), and Medical Education Partnership Initiative Nigeria (MEPIN) to achieve our objectives in this important health priority area. The specific aims of this proposal are: 1) advance training of HIV clinician-investigators capable of performing translational research on the pathogenesis, epidemiology, and prevention of AIDS-defining malignancies; 2) initiate training of oncology clinician-investigators capable of performing clinical trial research on novel interventions for the treatment and prevention of AIDS-defining malignancies; 3) develop training of pathology and virology scientists to perform research on oncogenic mechanisms and pathogenesis; 4) create a multidisciplinary research team capable of performing advanced in-country research on AIDS-defining malignancies in Jos, Nigeria. We will accomplish our training goals through strong mentorship and a combination of long-term master's and PhD degree granting programs, medium-term research project-driven training experiences, short-term in-country workshops, and innovative distance learning approaches. At the end of this project, we aspire to make the University of Jos a center of excellence in the research and care of AIDS malignancies in Nigeria and West Africa.

描述（由申请人提供）：艾滋病恶性肿瘤是撒哈拉以南非洲的一个严重问题，因为艾滋病毒的广泛流行和致癌性病毒合并感染的高负担。艾滋病紧急救援计划、全球基金和其他机构实施的抗逆转录病毒治疗方案显著降低了与艾滋病毒有关的发病率和死亡率，然而，恶性肿瘤和其他非传染性疾病的发病率正在上升，与此同时，人口正在老龄化。非洲大多数医疗和研究机构对应对这些新出现的卫生挑战准备不足。乔斯大学和乔斯大学教学医院艾滋病毒护理和治疗方案成立于2002年，目前为2万多名感染艾滋病毒的成人和儿童提供护理、治疗和支持。这个以大学为基础的中心是非洲最大的艾滋病护理提供者之一。为了改善西非和非洲大陆艾滋病相关恶性肿瘤的管理，乔斯大学/JUTH与西北大学联合提议建立一个多学科研究培训项目，该项目将以合作为基础，通过发展研究团队，专注于艾滋病定义恶性肿瘤（宫颈癌、卡波西肉瘤和非霍奇金淋巴瘤）的创新合作努力，提高尼日利亚的能力。我们的主要假设是，在癌症流行病学、临床试验、转化和艾滋病定义恶性肿瘤的实验室研究方面的能力建设将导致发病率和相关发病率和死亡率的显著降低。我们将利用美国总统艾滋病紧急救援方案（PEPFAR）、西北大学艾滋病国际培训和研究方案（northwest - aitrp）和尼日利亚医学教育伙伴关系倡议（MEPIN）提供的现有国内培训能力，实现我们在这一重要卫生优先领域的目标。该提案的具体目标是：1)对能够在艾滋病定义的恶性肿瘤的发病机制、流行病学和预防方面进行转化研究的艾滋病毒临床研究人员进行高级培训；2)启动肿瘤临床医师-研究人员的培训，使他们能够进行新颖的临床试验研究