A Fly Model of Traumatic Brain Injury
A Fly Model of Traumatic Brain Injury
批准号:
9034777
负责人:
DAVID WASSARMAN
金额:
$22.95万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-03-15 至 2018-02-28
关键词:
AffectAgeBehavioralBiological ProcessBrainBrain InjuriesCause of DeathCessation of lifeClinicalClinical TrialsCognitiveCollaborationsDataDevelopmentDevicesDiagnosisDiagnosticDrosophila genusDrosophila melanogasterEmotionalEventExperimental ModelsFailureFunctional disorderGenesGeneticGenotypeGlucoseGoalsHealthHemolymphHumanHyperglycemiaIncidenceIndividualInjuryIntestinesKnowledgeLeadLiquid substanceMechanicsMediatingMetabolismMethodsModelingMolecularNatureNervous system structureOutcomePathway interactionsPatientsPatternProbabilityProtocols documentationPublicationsResearchResearch PersonnelRiskRisk FactorsRodentSeveritiesSignal TransductionSpatial DistributionTestingTherapeuticTherapeutic InterventionThinkingTimeTraumaTraumatic Brain InjuryTreatment FailureValidationWorkbody systemclinically relevantflygastrointestinal systemgenetic approachgenetic variantgenome wide association studyimprovedinformation modelinsightnovelnovel strategiespublic health relevanceresponse to brain injurytherapy developmenttime intervaltooltranscriptome sequencing
中文摘要
英文摘要
DESCRIPTION (provided by applicant): We propose to explore the possibility of using fruit flies (Drosophila melanogaster) to study traumatic brain injury (TBI). This research is important because TBI is a major health problem. TBI occurs with high incidence, annually affecting about 1 in 500 people in the U.S., and it is associated with lifelong debilitating physical, cognitive, behavioral, and emotional outcomes. This research is also important because there are no therapies currently available to improve TBI outcomes. Since 1985, at least 21 clinical trials have been conducted, and none have shown a significant benefit in TBI outcomes. The failure to develop therapies is likely due to the complexity of TBI, both in terms of the severity and spatial distribution of injury to the brain and the elaborate responses of the brain to injury. Therefore, there is a need for new experimental models that can help us understand the main cellular and molecular mechanisms that underlie TBI outcomes, with the potential for identifying novel targets for diagnostic and therapeutic intervention. Our fly TBI model is significant because (1) it uses a mechanical force to inflict brain injury, similar to mechanisms that commonly occur in humans, (2) it generates a continuum of injury severity that predicts outcome severity, (3) it generates injury in a reproducible manner, making it possible to determine the contribution of genetic and environmental variables to outcomes, (4) it produces injury outcomes that mimic clinically relevant outcomes of TBI in humans, (5) it uses standardized experimental protocols that are affordable, simple, and widely applicable, and (6) it is supported by the unparalleled knowledge of the fly nervous system and experimental tools that are available for flies. To achieve the goal of determining the extent of similarity between fly and human TBI, we propose to identify genes and secondary events associated with death following TBI.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Anesthetic-Induced Neurotoxicity: Molecular Pathways and Genetic Risk Factors
-
批准号:10549751
-
项目类别:
-
资助金额:$34.99万
-
财政年份:2020
-
负责人:DAVID WASSARMAN
-
依托单位:
Genetic Analysis of Neurodegeneration in Drosophila
-
批准号:9018070
-
项目类别:
-
资助金额:$32.92万
-
财政年份:2014
-
负责人:DAVID WASSARMAN
-
依托单位:
Genetic Analysis of Neurodegeneration in Drosophila
-
批准号:9223746
-
项目类别:
-
资助金额:$32.92万
-
财政年份:2014
-
负责人:DAVID WASSARMAN
-
依托单位:
Genetic Analysis of Neurodegeneration in Drosophila
-
批准号:8688528
-
项目类别:
-
资助金额:$32.92万
-
财政年份:2014
-
负责人:DAVID WASSARMAN
-
依托单位:
Genetic Analysis of Neurodegeneration in Drosophila
-
批准号:8814288
-
项目类别:
-
资助金额:$32.92万
-
财政年份:2014
-
负责人:DAVID WASSARMAN
-
依托单位:
Neuroprotective drugs for A-T
-
批准号:8616449
-
项目类别:
-
资助金额:$22.17万
-
财政年份:2013
-
负责人:DAVID WASSARMAN
-
依托单位:
Neuroprotective drugs for A-T
-
批准号:8739687
-
项目类别:
-
资助金额:$18.22万
-
财政年份:2013
-
负责人:DAVID WASSARMAN
-
依托单位:
Genetic Analysis of Ataxia-telangiectasia
-
批准号:7537212
-
项目类别:
-
资助金额:$31.17万
-
财政年份:2007
-
负责人:DAVID WASSARMAN
-
依托单位:
Genetic Analysis of Ataxia-telangiectasia
-
批准号:7913120
-
项目类别:
-
资助金额:$2.78万
-
财政年份:2007
-
负责人:DAVID WASSARMAN
-
依托单位:
Genetic Analysis of Ataxia-telangiectasia
-
批准号:7738931
-
项目类别:
-
资助金额:$30.86万
-
财政年份:2007
-
负责人:DAVID WASSARMAN
-
依托单位:
Genetic Analysis of Ataxia-telangiectasia
-
批准号:7373017
-
项目类别:
-
资助金额:$31.17万
-
财政年份:2007
-
负责人:DAVID WASSARMAN
-
依托单位:
Genetic Analysis of Ataxia-telangiectasia
-
批准号:8197347
-
项目类别:
-
资助金额:$30.55万
-
财政年份:2007
-
负责人:DAVID WASSARMAN
-
依托单位:
Genetic Analysis of Ataxia-telangiectasia
-
批准号:7989397
-
项目类别:
-
资助金额:$30.55万
-
财政年份:2007
-
负责人:DAVID WASSARMAN
-
依托单位:
Mechanism of Transcription Control by Drosophila TAF250
-
批准号:6530212
-
项目类别:
-
资助金额:$28.54万
-
财政年份:2002
-
负责人:DAVID WASSARMAN
-
依托单位:
Mechanism of Transcription Control by Drosophila TAF250
-
批准号:6747344
-
项目类别:
-
资助金额:$28.5万
-
财政年份:2002
-
负责人:DAVID WASSARMAN
-
依托单位:
Mechanism of Transcription Control by Drosophila TAF250
-
批准号:6909982
-
项目类别:
-
资助金额:$28.49万
-
财政年份:2002
-
负责人:DAVID WASSARMAN
-
依托单位:
Mechanism of Transcription Control by Drosophila TAF250
-
批准号:6603455
-
项目类别:
-
资助金额:$28.52万
-
财政年份:2002
-
负责人:DAVID WASSARMAN
-
依托单位:
Mechanism of Transcription Control by Drosophila TAF250
-
批准号:7092977
-
项目类别:
-
资助金额:$27.8万
-
财政年份:2002
-
负责人:DAVID WASSARMAN
-
依托单位:
RNA POLYMERASE 11 TRANSCRIPTIONAL REGULATION IN DROSOPHILA
-
批准号:2452881
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:DAVID WASSARMAN
-
依托单位:
GENETIC ANALYSIS OF RNA POLYMERASE II TRANSCRIPTIONAL REGULATION IN DROSOPHILA
-
批准号:6108083
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:DAVID WASSARMAN
-
依托单位:
国内基金
海外基金
登录
查看更多内容
补阳还五汤通过AGE-RAGE通路调控脓毒症免疫失衡的机制与转化研究
-
批准号:JCZRLH202601523
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2026
-
负责人:
-
依托单位:
靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
-
批准号:JCZRQN202500010
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2025
-
负责人:
-
依托单位:
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
-
批准号:2025JJ70209
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2025
-
负责人:雷芬芳
-
依托单位:
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
-
批准号:--
-
项目类别:面上项目
-
资助金额:--
-
批准年份:2024
-
负责人:万荣
-
依托单位:
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
-
批准号:2023JJ50274
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2023
-
负责人:贺志明
-
依托单位:
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
-
批准号:--
-
项目类别:地区科学基金项目
-
资助金额:33万元
-
批准年份:2022
-
负责人:都义日
-
依托单位:
补肾健脾祛瘀方调控AGE/RAGE信号通路在再生障碍性贫血骨髓间充质干细胞功能受损的作用与机制研究
-
批准号:--
-
项目类别:面上项目
-
资助金额:52万元
-
批准年份:2022
-
负责人:叶宝东
-
依托单位:
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
-
批准号:
-
项目类别:省市级项目
-
资助金额:10.0万元
-
批准年份:2022
-
负责人:于海兵
-
依托单位:
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
-
批准号:81973577
-
项目类别:面上项目
-
资助金额:55.0万元
-
批准年份:2019
-
负责人:辛贵忠
-
依托单位:
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
-
批准号:81602908
-
项目类别:青年科学基金项目
-
资助金额:18.0万元
-
批准年份:2016
-
负责人:刘括
-
依托单位: