Iron Deficiency and Adversity in Early Life and Cardiometabolic Risk in Adulthood

生命早期的缺铁和逆境以及成年后的心脏代谢风险

• 批准号: 9121816
• 负责人: Jenalee Rae Doom
• 金额: $ 5.45万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9121816
• 关键词: Address; Adolescence; Adolescent; Adult; Adverse event; Affect; Age-Months; Anemia; Behavior; Behavioral; Blood Pressure; Body Composition; C-reactive protein; Cardiovascular Diseases; Cardiovascular system; Caring; Child; Childhood; Cognitive; Data; Development; Disadvantaged; Educational Status; Emotional; Environment; Event; Family Violence; Fathers; Fatty Liver; Fatty acid glycerol esters; Functional disorder; Goals; Health; Health behavior; Hormonal; Individual; Infant; Insulin; Intervention; Iron; Iron deficiency anemia; Knowledge; Lead; Leptin; Life; Life Stress; Link; Lipids; Liver diseases; Longevity; Longitudinal Studies; Malnutrition; Measures; Mediating; Mediator of activation protein; Mental Health; Metabolic; Metabolic syndrome; Metabolism; Neurobiology; Nutrient; Obesity; Outcome; Pathway interactions; Policies; Poverty; Preventive Intervention; Research; Research Personnel; Research Training; Risk; Risk Factors; Role; Schools; Social Functioning; Statistical Methods; Stress; Stroke; Subgroup; Testing; Time; Training; Waist-Hip Ratio; absorption; adolescent health; blood lipid; cardiometabolic risk; cardiovascular disorder risk; career; cognitive function; cohort; early experience; emerging adult; experience; fasting glucose; ghrelin; health disparity; high risk; infancy; iron deficiency; iron supplementation; maltreatment; maternal depression; mortality; negative mood; novel; nutrition; physical conditioning; prevent; programs; public health relevance; social

 DESCRIPTION (provided by applicant): Iron deficiency (ID) is associated with cardiovascular events such as stroke in children and cardiovascular disease (CVD) and all-cause mortality in adulthood. However, it is unknown whether ID in infancy contributes to the development of CVD and metabolic syndrome (cardio-metabolic risk). Studies of developmental effects of early ID demonstrate long-term negative effects on cognitive functioning, behavior, and socio-emotional development. Such changes may affect health behaviors that increase cardio-metabolic risk. Early adversity (e.g., poverty, maltreatment) is linked to higher cardio-metabolic risk and might also operate through similar cognitive, behavioral, and socio-emotional pathways. As ID is more common in low SES and other disadvantaged circumstances, a yet untested hypothesis is that there is a dual burden of having both ID and early adverse experiences that negatively affects functioning and subsequently increases cardio-metabolic risk. The goal of this project is to understand pathways between early ID and adversity and adult cardio-metabolic risk in order to identify targets for prevention and intervention and to detect subgroups at highest risk for disruptions in functioning and cardio-metabolic health. This goal will be accomplished using data from a large longitudinal study (n > 1000) of the effects of ID from infancy to early adulthood (PIs: Betsy Lozoff and Sheila Gahagan). Information on early ID and adversity (SES, life stress, maternal depression, father absence), adolescent cognitive functioning, health behaviors, and mental health, and adult cardio-metabolic risk (BMI, fat mass, blood pressure, blood lipids, hormonal regulators of metabolism) will be utilized. The first aim will test whether there are indirect effects of early ID on adult cardio-metabolic risk through pathways related to adolescent cognitive functioning, health behaviors, and mental health. The second aim will examine whether early adversity affects cardio-metabolic risk through similar or different pathways. The third aim will examine whether the dual burden of ID and adversity further increases cardio-metabolic risk in adulthood through these adolescent pathways. These aims will be accomplished with a training plan emphasizing the neurobiological and behavioral effects of early ID (sponsor Lozoff), childhood influences on cardio-metabolic risk (co-sponsor Gahagan), early adversity (Lozoff and Gahagan), and advanced statistical methods. Completing this research and training will be the first step in the PI's career plan to conduct policy-relevant research on the impact of nutrition and adversity on mental and physical health throughout the lifespan.

 描述（由申请人提供）：缺铁（ID）与心血管事件有关，例如儿童中风和成年心血管疾病（CVD）和全因死亡率。然而，尚不清楚婴儿期 ID 是否会导致 CVD 和代谢综合征（心脏代谢风险）的发生。对早期智力障碍发展影响的研究表明，它会对认知功能、行为和社会情感发展产生长期负面影响。这些变化可能会影响健康行为，从而增加心脏代谢风险。早期的逆境（例如贫困、虐待）与较高的心脏代谢风险有关，并且也可能通过类似的认知、行为和社会情感途径发挥作用。由于智力障碍在低社会经济地位和其他不利环境中更为常见，一个尚未得到检验的假设是，智力障碍和早期不良经历会带来双重负担，这些经历会对功能产生负面影响，从而增加心脏代谢风险。该项目的目标是了解早期 ID 与逆境和成人心脏代谢风险之间的途径，以便确定预防和干预的目标，并检测功能和心脏代谢健康中断风险最高的亚组。这一目标将通过一项大型纵向研究（n > 1000）的数据来实现，该研究涉及从婴儿期到成年早期的智力障碍影响（PI：Betsy Lozoff 和 Sheila Gahagan）。将利用有关早期 ID 和逆境（SES、生活压力、母亲抑郁、父亲缺席）、青少年认知功能、健康行为和心理健康以及成人心脏代谢风险（BMI、脂肪量、血压、血脂、代谢激素调节剂）的信息。第一个目标将测试早期 ID 是否通过与青少年认知功能、健康行为和心理健康相关的途径对成人心脏代谢风险产生间接影响。第二个目标将检查早期逆境是否通过相似或不同的途径影响心脏代谢风险。第三个目标将研究智力障碍和逆境的双重负担是否通过这些青少年途径进一步增加成年后的心脏代谢风险。这些目标将通过一个培训计划来实现，该计划强调早期智力障碍的神经生物学和行为影响（发起者 Lozoff）、童年对心脏代谢风险的影响（共同发起者 Gahagan）、早期逆境（Lozoff 和 Gahagan）以及先进的统计方法。完成这项研究和培训将是 PI 职业计划的第一步，该计划旨在就营养和逆境对整个生命周期身心健康的影响进行政策相关研究。