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Testing cortisol dysregulation as a mediator between early stress and adolescent cardiovascular health

测试皮质醇失调作为早期压力和青少年心血管健康之间的中介因素

基本信息

批准号：
10653780
负责人：
Jenalee Rae Doom
金额：
$ 15.36万
依托单位：
UNIVERSITY OF DENVER (COLORADO SEMINARY)
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10653780
关键词：
Address Adolescence Adolescent Adolescent obesity Adrenal Glands Adult American Heart Association Amygdaloid structure Area Arterial Fatty Streak Award Behavior Behavior assessment Behavioral Biological Birth Blood Pressure Cardiovascular Diseases Cardiovascular system Cause of Death Child Childhood Chronic Chronic stress Complex Consumption Data Decision Making Detection Development Diet Dietary Practices Dietary intake Disparity Eating Behavior Event Food Fright Goals Health Health Psychology Hippocampus Hormones Hydrocortisone Hypertension Hypothalamic structure Impairment Individual Inflammation Intervention Knowledge Lead Learning Life Life Cycle Stages Limbic System Link Literature Longitudinal Studies Measurement Measures Mediating Mediator Mentorship Metabolic Metabolism Obesity Outcome Overweight Parents Pathway interactions Phenotype Pituitary Gland Population Poverty Prefrontal Cortex Prevalence Process Psychologist Psychosocial Stress Reduce health disparities Regulation Research Research Personnel Risk Sampling Serum Markers Stress System Systems Development Testing Training United States Universities Work acute stress biological adaptation to stress cardiometabolism cardiovascular disorder prevention cardiovascular health career cohort early childhood early experience emotional eating ethnic minority population experience frontal lobe health disparity high risk hypothalamic-pituitary-adrenal axis improved inflammatory marker maltreatment neural neural circuit obesogenic psychosocial racial minority population response socioeconomics statistics young adult

项目摘要

PROJECT SUMMARY/ABSTRACT Cardiovascular disease is the leading cause of death in the United States. Psychosocial stress in early childhood has been linked to poorer cardiovascular health, with behavioral and biological alterations as potential mechanisms. One proposed mechanism between early stress and poorer cardiovascular health later in life is dysregulation in cortisol, a hormone that mediates stress responses and regulates metabolism. Cortisol dysregulation can include heightened or blunted cortisol levels, as both have been associated with chronic stress and poor health. A second proposed mechanism is alterations in diet and eating behaviors following early psychosocial stress as acute and chronic stress have been associated with obesogenic diet and eating behaviors. It is currently unknown whether cortisol dysregulation and altered diet and eating behaviors mediate the association between early psychosocial stress and poorer cardiovascular health in adolescence. The goal of this project is to understand whether cortisol dysregulation and altered diet and eating behaviors are pathways between early childhood stress and poorer cardiovascular health in adolescence. This work will identify targets for interventions to promote ideal cardiovascular health in populations who have experienced early stress. This goal will be accomplished using two complementary cohorts: new data collected on 100 diverse adolescents oversampled for high psychosocial risk and existing data from the Avon Longitudinal Study of Parents and Children (ALSPAC; N=9,600). These cohorts will be used to address two aims. Aim 1: To test the hypothesis that cortisol dysregulation mediates the association between psychosocial stress in early childhood and 1a) adolescent obesity, blood pressure, and serum markers of inflammation and poor cardiovascular health, and 1b) adolescent obesogenic dietary patterns and eating behaviors. Aim 2: To test the hypothesis that childhood obesogenic dietary patterns and eating behaviors mediates the association between psychosocial stress in early childhood and 2a) adolescent obesity, blood pressure, and serum markers of inflammation and poor cardiovascular health, and 2b) adolescent obesogenic dietary patterns and eating behaviors. I am a developmental psychologist with expertise in childhood psychosocial stress and cortisol regulation. This award will enable me to extend my expertise to assessing and improving cardiovascular health in adolescents. To conduct this research, I will complete a training plan based at the University of Denver under the primary mentorship of Dr. Elysia Davis. I will obtain training and content knowledge in the following areas: 1) cardiovascular health and gold-standard approaches for measurement of obesity, blood pressure, and serum markers of cardiovascular health; 2) diet and eating behavior assessment; 3) advanced statistics; and 4) conducting interventions. The research and training in this proposal will help me launch an independent career investigating pathways from early stress to cardiovascular health.

项目总结/文摘

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Advantages of a Developmental Psychopathology Approach to Studying the Antecedents of Physical Health.

发展精神病理学方法研究身体健康前因的优点。

DOI：
10.1002/icd.2250
发表时间：
2022
期刊：
Infant and child development
影响因子：
2.2
作者：
Doom,JenaleeR
通讯作者：
Doom,JenaleeR

Adverse and Benevolent Childhood Experiences Predict Mental Health During the COVID-19 Pandemic.

DOI：
10.1007/s42844-021-00038-6
发表时间：
2021
期刊：
Adversity and resilience science
影响因子：
0
作者：
Doom JR;Seok D;Narayan AJ;Fox KR
通讯作者：
Fox KR

Life stress and cortisol reactivity: An exploratory analysis of the effects of stress exposure across life on HPA-axis functioning.

DOI：
10.1017/s0954579419001779
发表时间：
2021-03
期刊：
Development and psychopathology
影响因子：
3.3
作者：
Young ES;Doom JR;Farrell AK;Carlson EA;Englund MM;Miller GE;Gunnar MR;Roisman GI;Simpson JA
通讯作者：
Simpson JA

Examination of race-based traumatic stress symptom networks in Black adults in the United States: A network analysis.

美国黑人成年人基于种族的创伤应激症状网络的检查：网络分析。