Hopkins Digestive Diseases Basic & Translational Research Core Center

霍普金斯消化疾病基础

• 批准号: 8969778
• 负责人: MARK DONOWITZ
• 金额: $ 118.99万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8969778
• 关键词: Appointment; Area; Basic Science; Biology; Biomedical Engineering; Biophysics; Cardiology; Cellular biology; Clinical; Clinical Investigator; Country; Development; Digestive System Disorders; Disease; Epithelial; Equipment; Evolution; Faculty; Family; Fibrosis; Figs - dietary; Fluorescence; Focus Groups; Foundations; Functional disorder; Funding; Genetic; Goals; Growth; Health; Heavy Metals; Housing; Human; Hypersensitivity; Image; Immunology; Individual; Inflammation; Injury; Institution; Interdisciplinary Study; Investments; Location; Malignant Neoplasms; Maps; Mass Spectrum Analysis; Medicine; Metals; Methodology; Microscope; Microscopy; Modeling; National Institute of Diabetes and Digestive and Kidney Diseases; Neurosciences; Nursing Faculty; Pathology; Patients; Pediatric Surgical Procedures; Pediatrics; Physiology; Post-Translational Protein Processing; Proteomics; Psychiatry; Reader; Regulation; Research; Research Personnel; Resolution; Resources; Science; Scientific Advances and Accomplishments; Scientist; Services; Signal Pathway; Signaling Protein; Stem cells; Technology; Time; Training; Transforming Growth Factor beta; Translating; Translational Research; United States National Institutes of Health; Work; base; cost effective; design; epigenetic marker; improved; innovative technologies; interest; lectures; member; oncology; posters; programs; protein protein interaction; public health relevance; sabbatical; senior faculty; square foot; symposium; trafficking; two-photon

 DESCRIPTION (provided by applicant): The NIDDK Hopkins Digestive Diseases Basic and Translational Research Core Center (DDBTRCC) was funded on 9/1/11 with the goal to facilitate GI science at Hopkins and apply research discoveries in a translational manner to form the background for improving the health of GI patients. The current Specific Aims of the Center are to capitalize on our advances and expand GI research at JHU in basic and translational epithelial biology in several areas of strength of Center investigators. These strengths are represented in our Focus Groups that include (i) Epithelial Transport: Function and Regulation (with the emphasis on transporters trafficking, protein-protein interactions and metal transport), (ii) Inflammation, Injury and Fibrosis, (iii) Neurogastroenterology, and (iv) GI Differentiation, Proliferation, Pre-cancer (with emphasis on signaling pathways, epigenetics, and biomarkers). The Center research base consists of 59 investigators (45 Members and 14 Associate Members), with a mix of faculty from basic science (25) and clinical departments (34). The Research Base is supported by 4 Scientific Cores: Proteomics Core (part of the JHU Mass Spectrometry Core), Imaging Core, Integrated Physiology Core, Translational Research Enhancement Core (TREC) and an Administrative Core. We have added major new areas to the services provided by the Cores that include proteomic analysis with an emphasize on post-translational modification, development of human enteroids as promising models of GI physiology and pathophysiology, and the hands-on training which makes these new models available to our investigators. The capabilities of the Imaging Core have been significantly increased by additional equipment (including two photon, spinning disk confocal and super resolution microscopes as well as a high-end fluorescence plate reader) and establishment of an Olympus Microscopy Demonstration Center in our Imaging Core (The Olympus Center is only the second such Center in the country to provide the newest Olympus microscopes for use by our investigators). Our TREC remains central to the JHU/CTSA development of translational research for the entire institution. The Administrative Core organizes the Pilot/Feasibility and Enrichment Programs (weekly Work-in-Progress, annual all day symposium, Hofmann Lecture and day of GI science plus poster session). The P/F program has funded 15 projects, 13 of those to new investigators and 2 to more senior faculty whose work is new to GI and will develop innovative technologies important for many Center investigators. To date, the 11 completed P/F projects have produced an 8.7-fold return on investment. Our Center has been given new space increasing it to ~3000 sq ft (doubling in size) in a single location. Our overall digestive disease (DD) funding has increased by 68% to $25.23 million, our NIH DD funding - by 58% to $7.2 million, of which 39% is NIDDK DD funding.

 描述（由申请人提供）：NIDDK霍普金斯消化疾病基础和转化研究核心中心（DDBTRCC）于2011年9月1日获得资助，其目标是促进霍普金斯的GI科学，并以转化的方式应用研究发现，以形成改善GI患者健康的背景。该中心目前的具体目标是利用我们的进步，并在中心研究人员的几个优势领域扩大JHU的基础和转化上皮生物学GI研究。这些优势体现在我们的焦点小组中，包括（i）上皮转运：功能和调节（重点是转运蛋白转运，蛋白质-蛋白质相互作用和金属转运），（ii）炎症，损伤和纤维化，（iii）神经胃肠病学，（iv）GI分化，增殖，癌前病变（重点是信号通路，表观遗传学和生物标志物）。该中心的研究基地由59名研究人员（45名成员和14名准成员）组成，其中包括基础科学（25名）和临床部门（34名）的教师。该研究基地由4个科学核心支持：蛋白质组学核心（JHU质谱核心的一部分），成像核心，综合生理学核心，转化研究增强核心（TREC）和行政核心。我们为核心提供的服务增加了主要的新领域，包括蛋白质组学分析，强调翻译后修饰，开发人类肠样蛋白作为GI生理学和病理生理学的有前途的模型，以及实践培训，使这些新模型可供我们的研究人员使用。成像核心的能力已经显着增加了额外的设备（包括双光子，旋转盘共聚焦和超分辨率显微镜以及高端荧光板阅读器），并在我们的成像核心建立了奥林巴斯显微镜演示中心（奥林巴斯中心是全国第二个提供最新奥林巴斯显微镜供我们的研究人员使用的中心）。我们的TREC仍然是整个机构转化研究的JHU/CTSA发展的核心。行政核心组织试点/可行性和丰富计划（每周进行中的工作，年度全天研讨会，霍夫曼讲座和GI科学加海报会议日）。P/F计划资助了15个项目，其中13个是新的研究人员，2个是更高级的教师，他们的工作对GI来说是新的，并将开发对许多中心研究人员很重要的创新技术。到目前为止，十一个已落成的物业╱楼宇项目已带来八点七倍的投资回报。我们的中心已经获得了新的空间，在一个位置将其增加到约3000平方英尺（大小翻了一番）。我们的总体消化系统疾病（DD）资金增加了68%，达到2523万美元，我们的NIH DD资金增加了58%，达到720万美元，其中39%是NIDDK DD资金。