Hopkins Digestive Diseases Basic & Translational Research Core Center

霍普金斯消化疾病基础

• 批准号: 9279100
• 负责人: MARK DONOWITZ
• 金额: $ 118.99万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9279100
• 关键词: Appointment; Area; Basic Science; Biology; Biomedical Engineering; Biophysics; Cardiology; Cellular biology; Clinical; Clinical Investigator; Country; Development; Digestive System Disorders; Disease; Epithelial; Equipment; Evolution; Faculty; Family; Fibrosis; Fluorescence; Focus Groups; Foundations; Functional disorder; Funding; Genetic; Goals; Growth; Health; Heavy Metals; Human; Hypersensitivity; Image; Immunology; Individual; Inflammation; Injury; Institution; Interdisciplinary Study; Investments; Location; Maps; Mass Spectrum Analysis; Medicine; Metals; Methodology; Microscope; Microscopy; Modeling; National Institute of Diabetes and Digestive and Kidney Diseases; Neurosciences; Nursing Faculty; Pathology; Patients; Pediatric Surgical Procedures; Pediatrics; Physiology; Post-Translational Protein Processing; Proteomics; Psychiatry; Reader; Regulation; Research; Research Personnel; Resolution; Resources; Retreatment; Science; Scientific Advances and Accomplishments; Scientist; Services; Signal Pathway; Signaling Protein; Stem cells; Technology; Time; Training; Transforming Growth Factor beta; Translating; Translational Research; United States National Institutes of Health; Work; base; cost effective; design; epigenetic marker; imaging capabilities; improved; innovative technologies; interest; lectures; member; oncology; posters; programs; protein protein interaction; public health relevance; sabbatical; senior faculty; symposium; trafficking; two-photon

 DESCRIPTION (provided by applicant): The NIDDK Hopkins Digestive Diseases Basic and Translational Research Core Center (DDBTRCC) was funded on 9/1/11 with the goal to facilitate GI science at Hopkins and apply research discoveries in a translational manner to form the background for improving the health of GI patients. The current Specific Aims of the Center are to capitalize on our advances and expand GI research at JHU in basic and translational epithelial biology in several areas of strength of Center investigators. These strengths are represented in our Focus Groups that include (i) Epithelial Transport: Function and Regulation (with the emphasis on transporters trafficking, protein-protein interactions and metal transport), (ii) Inflammation, Injury and Fibrosis, (iii) Neurogastroenterology, and (iv) GI Differentiation, Proliferation, Pre-cancer (with emphasis on signaling pathways, epigenetics, and biomarkers). The Center research base consists of 59 investigators (45 Members and 14 Associate Members), with a mix of faculty from basic science (25) and clinical departments (34). The Research Base is supported by 4 Scientific Cores: Proteomics Core (part of the JHU Mass Spectrometry Core), Imaging Core, Integrated Physiology Core, Translational Research Enhancement Core (TREC) and an Administrative Core. We have added major new areas to the services provided by the Cores that include proteomic analysis with an emphasize on post-translational modification, development of human enteroids as promising models of GI physiology and pathophysiology, and the hands-on training which makes these new models available to our investigators. The capabilities of the Imaging Core have been significantly increased by additional equipment (including two photon, spinning disk confocal and super resolution microscopes as well as a high-end fluorescence plate reader) and establishment of an Olympus Microscopy Demonstration Center in our Imaging Core (The Olympus Center is only the second such Center in the country to provide the newest Olympus microscopes for use by our investigators). Our TREC remains central to the JHU/CTSA development of translational research for the entire institution. The Administrative Core organizes the Pilot/Feasibility and Enrichment Programs (weekly Work-in-Progress, annual all day symposium, Hofmann Lecture and day of GI science plus poster session). The P/F program has funded 15 projects, 13 of those to new investigators and 2 to more senior faculty whose work is new to GI and will develop innovative technologies important for many Center investigators. To date, the 11 completed P/F projects have produced an 8.7-fold return on investment. Our Center has been given new space increasing it to ~3000 sq ft (doubling in size) in a single location. Our overall digestive disease (DD) funding has increased by 68% to $25.23 million, our NIH DD funding - by 58% to $7.2 million, of which 39% is NIDDK DD funding.

 描述（由申请人提供）：NIDDK 霍普金斯消化疾病基础与转化研究核心中心 (DDBTRCC) 于 2011 年 9 月 1 日获得资助，目标是促进霍普金斯大学的胃肠道科学发展，并以转化方式应用研究发现，为改善胃肠道患者的健康奠定基础。该中心当前的具体目标是利用我们的进步，并在中心研究人员的几个优势领域扩大约翰霍普金斯大学在基础和转化上皮生物学方面的胃肠道研究。这些优势体现在我们的焦点小组中，包括 (i) 上皮转运：功能和调节（重点是转运蛋白转运、蛋白质-蛋白质相互作用和金属转运），(ii) 炎症、损伤和纤维化，(iii) 神经胃肠病学，以及 (iv) 胃肠道分化、增殖、癌前病变（重点是信号传导途径、表观遗传学和 生物标志物）。中心研究基地由 59 名研究人员组成（45 名会员和 14 名准会员），其中包括来自基础科学（25 名）和临床科室（34 名）的教员。该研究基地由 4 个科学核心支持：蛋白质组学核心（JHU 质谱核心的一部分）、成像核心、综合生理学核心、转化研究增强核心 (TREC) 和行政核心。我们在核心提供的服务中增加了主要的新领域，包括强调翻译后修饰的蛋白质组分析、开发人类肠类作为胃肠道生理学和病理生理学的有前途的模型，以及使我们的研究人员可以使用这些新模型的实践培训。通过额外的设备（包括两台光子、转盘共焦和超分辨率显微镜以及高端荧光读板机）以及在我们的成像核心中建立奥林巴斯显微镜演示中心（奥林巴斯中心是国内第二个提供最新奥林巴斯显微镜供我们的研究人员使用的此类中心），显着增强了成像核心的功能。我们的 TREC 仍然是 JHU/CTSA 整个机构转化研究发展的核心。行政核心组织试点/可行性和丰富计划（每周进行中的工作、年度全天研讨会、霍夫曼讲座和 GI 科学日加海报会议）。 P/F 计划资助了 15 个项目，其中 13 个项目资助了新研究人员，2 个项目资助了更高级的教员，他们的工作对 GI 来说是新的，并将开发对许多中心研究人员来说很重要的创新技术。迄今为止，已完成的11个P/F项目已产生8.7倍的投资回报。我们的中心获得了新的空间，单个地点的面积增加至约 3000 平方英尺（面积增加了一倍）。我们的总体消化疾病 (DD) 资金增加了 68%，达到 2523 万美元，我们的 NIH DD 资金增加了 58%，达到 720 万美元，其中 39% 是 NIDDK DD 资金。