Constructing 4-dimensional Infant Cortical Surface Atlases

构建 4 维婴儿皮质表面图谱

• 批准号: 9019697
• 负责人: Gang Li
• 金额: $ 19万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9019697
• 关键词: Accounting; Address; Adopted; Adult; Age; Age-Months; Appearance; Area; Atlases; Base of the Brain; Biological; Biomedical Research; Birth; Brain; Cerebral cortex; Child; Communities; Computing Methodologies; Development; Dimensions; Elderly; Ensure; Four-dimensional; Goals; Health; Human; Image; Imagery; Individual; Infant; Infant Development; Joints; Knowledge; Life; MRI Scans; Magnetic Resonance Imaging; Maps; Measures; Mental disorders; Methods; Modeling; Molecular; National Institute of Mental Health; Nature; Neurodevelopmental Disorder; Pattern; Play; Population; Positioning Attribute; Property; Role; Scanning; Shapes; Staging; Statistical Data Interpretation; Strategic Planning; Surface; Thick; Tissues; base; cohort; critical period; improved; innovation; insight; neonate; neuroimaging; neuropsychiatric disorder; postnatal; tool

 DESCRIPTION (provided by applicant): Neuroimaging studies of the dynamic and critical cortex development during early postnatal stages would greatly increase our very limited knowledge on normal early brain development, and also provide important insights into neurodevelopmental origins and abnormal trajectories of neuropsychiatric disorders. In neuroimaging studies, cortical surface-based brain atlases play fundamental and increasingly important roles for normalization, analysis, visualization, and comparison of the highly-folded cortex across different studies. Existing cortical surface atlases developed for adults and neonates are problematic when used for studying the dynamic developing cortex in infants, due to dramatic differences of cortical size, shape, and folding degree. Meanwhile, parcellations in these cortical surfaces atlases based on the sulcal-gyral landmarks are also problematic when used for localization of functional regions, due to poor matching of sulcal-gyral patterns with the microstructural borders. To address all these limitations, we aim to construct longitudinally-consistent, age-specific population representative shapes of multi-scale cortical folding at 1, 3, 6, 9, 12, 18 and 24 months of age (Aim 1). To ensure the longitudinal consistency of 4D atlases, we will capitalize on within- subject longitudinal constraints to establish consistent inter-subjec cortical correspondences. To capture the multi-scale nature of cortical folding, we will characterize cortical folding by using spherical wavelet decomposition of curvature information. To ensure the clarity and representativeness of cortical folding in atlases, we will develop a sparse representation method to adaptively integrate individuals' cortical folding. Next, we aim to parcellate 4D infant cortical surface atlases into distinct regions based on the dynamic developmental trajectories of cortical thickness, surface area, and cortical local gyrification (Ai 2). The dynamic cortical developmental trajectories indicate the underlying changes of microstructures, which essentially determine the molecular organization and functional principles of the cortex, and thus can better define the developmentally, microstructurally, and functionally distinct regions than the conventional sulcalgyral landmarks. Finally, we will package our 4D infant cortical surface atlases and release them freely to the community.