Social Processes in individuals at clinical high-risk for psychosis

临床精神病高危个体的社会过程

基本信息

批准号：
8986210
负责人：
Andrea Pelletier Baldelli
金额：
$ 3.46万
依托单位：
UNIVERSITY OF COLORADO
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-01-01 至 2016-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8986210
关键词：
Affect Affective Amygdaloid structure Anhedonia Area Autistic Disorder Awareness Behavior Behavioral Characteristics Clinical Cognitive Data Developmental Process Diffusion Magnetic Resonance Imaging Disease Early Intervention Emotional Emotions Etiology Exhibits Eye Face Family Functional disorder Health Image Image Analysis Impaired cognition Impairment Individual Individual Differences Interview Investigation Knowledge Measures Medial Mental disorders Mind National Institute of Mental Health Nature Nucleus Accumbens Parietal Parietal Lobe Participant Patient Self-Report Perception Phenotype Population Group Prefrontal Cortex Preventive treatment Process Property Psychotic Disorders Questionnaires Research Research Domain Criteria Risk Schizophrenia Self Perception Social Behavior Social Functioning Social Processes Societies Staging Structure Structure of middle temporal gyrus Structure of superior temporal sulcus Superior temporal gyrus Symptoms Syndrome System Temporal Lobe Testing Training Training and Education Ventral Tegmental Area Work associated symptom base brain behavior career cost design endophenotype evidence base first episode psychosis fusiform face area gray matter high risk improved indexing insight meetings mental state neural circuit neural correlate neuroimaging psychotic symptoms relating to nervous system reward circuitry severe mental illness skills social social attachment social communication symposium symptomatology theories white matter

项目摘要

DESCRIPTION (provided by applicant): Social deficits are a hallmark characteristic of schizophrenia, and recent evidence suggests that this impairment may be evident in the prodromal stage of psychosis (the stage immediately preceding the first episode of psychosis). The current conceptualization of social processes outlines four functional constructs including affiliation and attachment, social communication, perception/understanding of self, and perception/understanding of others. This approach to understanding social processing highlights a dimensional understanding of social behavior and emphasizes assessing these constructs from multiple levels of analyses (e.g., brain, behavior, self-report, etc.). Although several distict studies have implicated areas of social processing dysfunction in the prodrome (e.g., emotion recognition and theory of mind) to date, there have been no multimodal investigations designed to determine functioning across the four constructs. Clarifying our understanding of social processing in a clinical high-risk group (CHR) (those deemed to meet clinical criteria for a prodromal syndrome) stands to increase our knowledge of social processing more broadly as well as improve our understanding of the etiology of psychosis. This project aims to clarify the nature of social processes in a CHR group, test for neuroanatomical correlates of the four constructs, and to assess for individual differences in the relationship between psychotic symptoms and social processes. In this study, 40 individuals with a prodromal syndrome and 40 controls will be evaluated by using multiple levels of analysis (i.e., behavior, imaging, self-report). Social constructs will be measured as follows: Affiliation and attachment will be assessed using a measure of social anhedonia from the Structured Interview for Prodromal Syndromes (SIPS); social communication will be evaluated using various emotion-related tasks (ER-40, FEDT, MSCEIT) as well as questionnaires to get at more productive aspects of social communication (social responsiveness scale, social communication questionnaire, broad autism phenotype); perception/understanding of self will be measured using the Beck Cognitive Insight Scale and Scale to Assess Unawareness of Mental Disorder insight scales; finally, perception/understanding of others will be assessed using The Awareness of Social Inference Test. Structural and diffusion tensor imaging will also be used in order to evaluate neural regions and circuitry currently believed to be involved in social functioning. Throughout the course of this project, the applicant will receive education and training in social processes, work with experts in the field in regards to affective neuroimaging, statistical analyses of imaging data, and prodromal syndromes. This training plan, incorporating coursework, specialized training in social domains, colloquia/conference attendance, and work with the Sponsor/Co-Sponsors will enable the applicant to effectively complete the current proposal as well as develop the necessary skills to pursue an independent research career investigating social processes, and specifically, how this functioning domain manifests in psychotic disorders.

描述（由申请人提供）：社会缺陷是精神分裂症的标志性特征，最近的证据表明，这种障碍可能在精神病的前驱阶段（在精神病的第一集之前紧接）可能很明显。当前的社会过程概念化概述了四个功能构造，包括隶属关系和依恋，社会交流，对自我的感知/理解以及对他人的感知/理解。这种理解社会处理的方法强调了对社会行为的维度理解，并强调从多个分析（例如大脑，行为，自我报告等）中评估这些结构。尽管几项扩展的研究已暗示了迄今为止，迄今为止，尚无旨在确定四个构造的功能的多模式研究的前代（例如，情绪识别和心理理论）的社会加工功能障碍领域。澄清我们对临床高危群体（CHR）（符合前驱综合症临床标准的人）中对社会处理的理解，可以更广泛地增强我们对社会处理的了解，并提高我们对精神病病因的理解。该项目旨在阐明CHR组中社会过程的性质，测试这四种结构的神经解剖学相关性，并评估精神病症状与社会过程之间关系的个体差异。在这项研究中，将使用多个分析（即行为，成像，自我报告）评估40个患有前驱综合征和40个对照的人。社会结构将如下衡量：将使用从结构化访谈中的社会抗议综合症（SIPS）中评估隶属关系和依恋；将使用各种与情感相关的任务（ER-40，FedT，MSCEIT）以及问卷调查社会交流，以了解社会交流的更有生产力（社会响应量表，社会沟通问卷，广泛的自闭症表型）；对自我的看法/理解将使用贝克认知见解量表和量表来评估精神障碍洞察量表的不认识；最后，将使用社会推理测试的意识来评估对他人的看法/理解。还将使用结构和扩散张量成像，以评估当前被认为参与社会功能的神经区域和电路。在整个项目的整个过程中，申请人将接受社会过程中的教育和培训在情感神经影像学，成像数据的统计分析和前驱综合症方面，该领域的专家。该培训计划，结合了课程工作，在社会领域，座谈会/会议出勤的专业培训以及与赞助商/共同发起人合作，将使申请人能够有效地完成当前的建议，并开发必要的技能，从而追求独立的研究职业研究社会过程，特别是在精神病分子中发挥作用。