The Development of Eating Behavior in Infancy

婴儿期饮食行为的发展

• 批准号: 9111517
• 负责人: Julie C Lumeng
• 金额: $ 3.88万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9111517
• 关键词: 2 year old; Adult; Advertising; Age; Appetite Regulation; Behavior; Biology; Birth; Birth Weight; Breast Feeding; Child; Childhood; Consumption; Cues; Desire for food; Development; Diet; Eating Behavior; Energy Intake; Food; Future; Goals; Growth; Hunger; Individual; Individual Differences; Infant; Intake; Intervention; Investigation; Knowledge; Lead; Life; Link; Longevity; Measurement; Measures; Methods; Milk; Modeling; Mothers; Motor Activity; Newborn Infant; Obesity; Overweight; Pattern; Physical activity; Prevention; Prevention program; Psychosocial Stress; Public Health; Reading; Recruitment Activity; Reporting; Risk Factors; Satiation; Shapes; Solid; Sucrose; Testing; Time; Translating; Weight; Weight Gain; Work; age group; behavioral construct; cohort; early childhood; eating in absence of hunger; effective intervention; feeding; hedonic; improved; infancy; infant temperament; novel; obesity prevention; obesity risk; prenatal; prevent; protective effect; public health relevance; response; sedentary; success; sucking; sweet taste perception

 DESCRIPTION (provided by applicant): Obesity is a significant public health problem. Preventing obesity is much more effective than treating it and once obesity is established it is very likely to persist throughout the lifespan. Prevention programs have had limited success and efforts have therefore increasingly focused on younger and younger age groups. By age 2 years, 27 percent of children are already overweight or obese and the rate of weight gain in the first year of life is an independent and robust risk factor for obesity later in childhood and into adulthood, independent of prenatal factors or birth weight. Efforts have therefore begun to focus on the rate of weight gain in infancy. The mechanism of rapid weight gain in the first year of life is currently unknown. The classic predictors of obesity in later childhood and adulthood, such as physical activity, sedentary behavior, and dietary composition, do not translate directly to infancy. In addition, the accumulating body of evidence does not provide robust support for protective effects of breastfeeding or delayed introduction of solid foods. Interventionists have therefore most recently focused efforts on the notion that mothers misread infant hunger and satiety cues and as a result, over-feed them. Underlying these interventions is the implied hypothesis that infants would naturally accurately self-regulate caloric intake if mothers could accurately read the infant's cues. In this application we propose an alternate conceptual model, however. Specifically, we propose that some individuals have greater hunger than others, and that these inter-individual differences are detectable and have high stability from early infancy. We propose that in order to develop effective interventions to prevent rapid weight gain in infancy, there is a need to first understand infant hunger. The goal of this application is to bettr define distinct domains of infant eating behavior, their measurement, their development over time, their correlates, and their association with rapid infant weight gain. Ultimately, the work wll contribute to the basic scientific understanding of the ontogeny of appetitive drive very early in the life span and lead to the development of more precise and targeted interventions to shape infant appetitive drive. We will recruit a cohort of 325 infants in the newborn period and measure, using unique observational methods and maternal report measures, eating behavior constructs including sucking vigor, satiety responsiveness, hedonic response to sweet taste, soothing effect of sucrose, persistent working for food, and eating in the absence of hunger. Our specific aims therefore are: Aim 1: To identify domains of infant eating behavior and their trajectories of development over the first year of life. Aim 2: To test the hypothesis that specifi trajectories of specific infant eating behaviors are associated with more rapid rates of infant weight gain. Aim 3: To test the hypothesis that the infant eating behavior domains linked with rapid rates of weight gain are predicted by infant temperament; psychosocial stress; and maternal obesity, eating behavior, and diet.

 描述（由申请人提供）：肥胖是一个重大的公共卫生问题。预防肥胖比治疗它更有效，一旦肥胖建立，它很可能在整个生命周期中持续存在。预防方案取得的成功有限，因此，工作越来越多地集中在越来越年轻的年龄组。到2岁时，27%的儿童已经超重或肥胖，出生后第一年的体重增加率是儿童后期和儿童期肥胖的独立和强大的风险因素。 成年期，独立于产前因素或出生体重。因此，人们开始关注婴儿期体重增加的速度。出生后第一年体重快速增加的机制 目前尚不清楚。儿童后期和成年期肥胖的经典预测因素，如身体活动，久坐行为和饮食组成，并不直接转化为婴儿期。此外，越来越多的证据并没有为母乳喂养或延迟引入固体食物的保护作用提供强有力的支持。因此，干预主义者最近将精力集中在母亲误读婴儿饥饿和饱足的暗示，从而过度喂养他们的概念上。这些干预措施的基础是一个隐含的假设，即如果母亲能准确地阅读婴儿的暗示，婴儿自然会准确地自我调节热量摄入。然而，在本应用程序中，我们提出了一个替代概念模型。具体来说，我们认为有些人比其他人更饥饿，这些个体间的差异是可检测的，并且从婴儿早期就具有很高的稳定性。我们建议，为了制定有效的干预措施，以防止婴儿期体重迅速增加，有必要首先了解婴儿饥饿。本申请的目的是更好地定义婴儿饮食行为的不同领域，它们的测量，它们随时间的发展，它们的相关性，以及它们与婴儿体重快速增加的关联。最终，这项工作将有助于对生命早期食欲驱动的个体发生的基本科学理解，并导致更精确和有针对性的干预措施的发展，以塑造婴儿食欲驱动。我们将招募一组新生儿期的325名婴儿，并使用独特的观察方法和母亲报告措施测量饮食行为结构，包括吸吮活力，饱腹感反应，对甜味的享乐反应，蔗糖的舒缓作用，持续工作的食物，并在没有饥饿的情况下进食。因此，我们的具体目标是：目标1：确定婴儿饮食行为的领域及其在生命第一年的发展轨迹。目标二：为了验证婴儿特定饮食行为的特定轨迹与婴儿体重增加速度更快相关的假设。目标三：检验以下假设：婴儿的气质、心理社会压力、母亲肥胖、饮食行为和饮食可预测与体重快速增加相关的婴儿饮食行为领域。