A versatile high-performance optical mammography co-imager

多功能高性能光学乳腺X线摄影联合成像仪

• 批准号: 9080941
• 负责人: Qianqian Fang
• 金额: $ 30.86万
• 依托单位: NORTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-26 至 2021-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9080941
• 关键词: Address; Adoption; Algorithms; American Cancer Society; Benign; Biopsy; Blinded; Breast; Breast Cancer Patient; Cancerous; Clinic; Clinical; Clinical Research; Collaborations; Complex; Coupling; Data; Detection; Development; Diagnosis; Diagnostic; Digital Mammography; Disadvantaged; Disease; Evolution; Exercise; Future; Future Generations; Goals; Healthcare; Hemoglobin; Human; Image; Investigation; Lead; Lesion; Libraries; Lighting; Malignant - descriptor; Malignant Neoplasms; Mammary Neoplasms; Mammography; Measurement; Measures; Metabolism; Methods; Modality; Morphologic artifacts; Multicenter Trials; New Device Approvals; Normal tissue morphology; Optical Tomography; Optics; Oxygen; Performance; Physiological; Physiology; Population; Process; Reader; Regulatory Pathway; Research; Resolution; Roentgen Rays; Sampling; Scanning; Sensitivity and Specificity; Shapes; Specificity; Staging; Structure; System; Techniques; Technology; Time; Tissues; Translations; Validation; Variant; Vendor; Woman; angiogenesis; base; breast imaging; breast lesion; cost; cost efficient; data acquisition; density; diffuse optical tomography; digital; flexibility; healthy volunteer; image reconstruction; image registration; imaging modality; imaging system; improved; in vivo; innovation; malignant breast neoplasm; mortality; novel; optical imaging; prognostic; prognostic value; programs; prototype; public health relevance; reconstruction; success; system architecture; tool; transmission process; tumor

 DESCRIPTION (provided by applicant): X-ray mammography has contributed to a reduction in mortality due to breast cancer. It is inherently limited, though, by its inability to directly observe physiological information relevant to the function of cancerous tissue. This ultimately limits the specificity and prognostic ability of x-ray mammography. Diffuse optical tomography (DOT) is a promising imaging modality that provides information on angiogenesis and hemoglobin oxygen saturation - key parameters tied to the presence and evolution of cancer. It suffers, however, from limited spatial resolution and unsatisfactory image quality due to optical coupling variations. These limitations inhibit straightforward interpretation of the optical images obtained and widespread clinical validation of DOT. This obstacle can be overcome by synergistically "fusing" the optical and x-ray information in a multi-modal imaging configuration - that is, by combining the two modalities, we can overcome their respective limitations and achieve a new multi-modality imaging method with enhanced specificity and prognostic value. Building upon our successful initial collaboration with Philips Healthcare and strong preliminary data, we propose to fundamentally address the current clinical limitations in x-ray mammography by developing a vendor- independent high-performance optical mammography co-imager, or OMCI, with which the optical measurements can be jointly reconstructed using the structural guidance from a separately acquired 2D or 3D digital x-ray mammogram. We believe that this approach has significant advantage from a clinical translation standpoint, as it directly capitalizes on the over 9,000 installed digital mammography systems in the US, and is expected to be compatible with future generations of mammography scanners. The proposed approach will dramatically reduce the time delays, costs, and complex regulatory pathways associated with developing and deploying integrated optical/mammography imaging systems. In the proposed study, we will build a new DOT system architecture for in vivo transmission human imaging and develop innovative prior-guided reconstruction algorithms to utilize high-density optical measurements and significantly enhance the optical image resolution and quality. Supported by a strong clinical team, we will perform a clinical study to explore the sensitivity an specificity of detecting malignant lesions using the proposed system. We will systematically compare the OMCI-assisted mammography diagnosis with stand-alone mammography through a blinded reader study to further confirm the clinical value of the added functional information. This result will prepare us for future multi- center trials and regulatory approval for this new device.

 描述（由适用提供）：X射线乳房X线摄影导致乳腺癌死亡率降低。但是，它本质上是由于无法直接观察与癌组织功能有关的物理信息而受到限制。这最终限制了X射线乳房摄影的特异性和预后能力。弥漫性光学断层扫描（DOT）是一种有希望的成像方式，可提供有关血管生成和血红蛋白氧饱和度的信息 - 与癌症的存在和演变相关的关键参数。但是，由于光学耦合变化，它受到有限的空间分辨率和不令人满意的图像质量的影响。这些限制抑制了光学图像的直接解释 获得并广泛地对DOT进行了临床验证。可以通过在多模式成像配置中协同“融合”光学和X射线信息来克服此障碍 - 也就是说，通过结合两种方式，我们可以克服它们各自的局限性，并获得具有增强特异性和预后价值的新的多模式成像方法。在我们成功与飞利浦医疗保健和强大的初步数据的最初合作的基础上，我们建议通过开发X射线乳房X线摄影的当前临床限制，通过开发供应商独立的高性能光学乳房X线摄影共同成像或OMCI，或者使用分别进行的MORCHOMPOMPOMPOMPOMPOMPOMPONCH或OMCI，可以将光学测量置于该X射线X线X线X摄影术。我们认为，从临床翻译的角度来看，这种方法具有显着优势，因为它直接 在美国的9,000多个已安装的数字乳房X线摄影系统上大写，预计将与后代的乳房X线摄影扫描仪兼容。所提出的方法将大大减少与开发和部署集成的光学/乳房X线摄影成像系统相关的时间延迟，成本和复杂的调节途径。在拟议的研究中，我们将构建一个新的DOT系统体系结构，用于体内传输人体成像，并开发创新的先前引导的重建算法来利用高密度光学测量，并显着增强光学图像分辨率和质量。在一个强大的临床团队的支持下，我们将进行一项临床研究，以探索使用拟议系统检测恶性课程的特异性。我们将系统地将OMCI辅助乳腺摄影诊断与独立乳腺X线摄影通过盲目的读者研究进行比较，以进一步确认附加功能信息的临床价值。这一结果将使我们为此新设备的多中心试验和监管批准做好准备。