Center For Urban Responses to Environmental Stressors (CURES)

描述(由申请人提供) 位于底特律中心的韦恩州立大学“城市环境应激源反应中心”(CURES)致力于了解城市工业化环境中普遍存在的化学和非化学应激源对人类健康的影响。特别强调易受环境影响和易患环境疾病的脆弱人群(例如，社会经济地位低的儿童和成人、老年人、移民、难民和急救人员)的寿命窗口。治疗中心的假设是，在工业化的城市环境(如底特律)中，危及生活质量的疾病是个人遗传和表观遗传构成、营养状况和环境应激源之间动态相互作用的结果，环境应激源包括慢性低水平毒物暴露以及心理-社会和身体应激源，这些压力源重新编程关键的细胞调节网络以利于发病。四个以疾病为导向的研究兴趣小组是人口和基础科学家以及社区成员的跨学科中心，他们对环境暴露在1)免疫紊乱、2)代谢疾病、3)癌症和4)精神健康障碍中的作用感兴趣。跨学科/跨领域整合团队(TRANSIC)与社区顾问合作，应用跨学科的综合方法来解决环境健康问题。综合健康科学设施核心中心引导研究人员向转化性研究过渡，并提供干细胞和人类生物样品服务。暴露签名设施核心使中心成员能够将集成的、最先进的基因组、表观基因组、蛋白质组和生物信息学策略应用于环境健康科学研究。社区外展和参与核心为处于环境疾病风险中的城市社区和中心成员之间提供双向交流。CURES还赞助专注于职业发展和新项目开发的项目。治疗中心是一个充满活力的跨学科研究团队，致力于环境疾病预防，并在底特律创造更清洁、更健康的生活和工作环境。

DESCRIPTION (provided by applicant) Situated in the heart of Detroit, the Wayne State University "Center for Urban Responses to Environmental Stressors" (CURES) is focused on understanding how exposures to stressors that are prevalent in the urban industrialized environment, both chemical and non-chemical, impact human health. Special emphasis is placed on life windows of heightened susceptibility to environmental exposure and vulnerable persons at risk for environmental disease (e.g., children and adults of low socio-economic status, older adults, immigrants, refugees, and first responders). The hypothesis of the CURES Center is that diseases that compromise the quality of life in an industrialized urban environment, such as Detroit, occur as a consequence of dynamic interactions among an individual's genetic and epigenetic make-up, nutritional status, and environmental stressors, which include chronic low-level toxicant exposures as well as psycho-social and physical stressors, that re-program key cellular regulatory networks to favor pathogenesis. Four disease-oriented research interest groups serve as interdisciplinary hubs for population and basic scientists and community members interested in the role of environmental exposure in 1) immune disorders, 2) metabolic disease, 3) cancer, and 4) mental health disturbances. The Transdisciplinary/Translational Integration team (TRANSIT) works with community advisors to apply an integrated transdisciplinary approach to solving environmental health problems. The Integrative Health Sciences Facility Core guides Center researchers transitioning toward translational research studies and provides stem cell and human biospecimen services. The Exposure Signatures Facility Core enables Center members to apply integrated, state-of-the-art genomic, epigenomic, proteomic, and bioinformatic strategies to environmental health science research. The Community Outreach and Engagement Core provides for bi-directional exchange between the urban community at risk for environmental illness and Center members. CURES also sponsors programs focused on career and new project development. The CURES Center is a dynamic transdisciplinary research team that is dedicated to environmental disease prevention and creating a cleaner and healthier living and working environment in the city of Detroit.