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Center For Urban Responses to Environmental Stressors (CURES)

城市环境压力应对中心 (CURES)

基本信息

批准号：
9049259
负责人：
Melissa A Runge-Morris
金额：
$ 92.48万
依托单位：
WAYNE STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-06-05 至 2017-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9049259
关键词：
Address Adult Affect Animals Basic Science Bioinformatics Blood Chemicals Child Chronic Cities Collaborations Communities Community Outreach Complex Core Facility Development Disease Elderly Environment Environmental Exposure Environmental Health Environmental Illness Environmental Policy Environmental Pollutants Environmental Risk Factor Epidemiology Epigenetic Process Exposure to Fostering Gene Expression Genes Genetic Genomics Goals Health Health Sciences Heart Human Immigrant Immune System Diseases Immune system Individual Integrative Medicine Interest Group Leadership Learning Life Malignant Neoplasms Mental Health Mentors Metabolic Diseases Metabolism Modeling Molecular Profiling Monitor Neonatal Nutritional status Pathogenesis Persons Pilot Projects Policies Policy Maker Population Population Heterogeneity Predisposition Process Proteomics Public Health Quality of life Refugees Research Research Personnel Research Project Grants Resources Risk Role Science Scientist Services Spottings Testing Toxic Environmental Substances Toxicant exposure Translational Research Universities Vulnerable Populations Work base biobank career career development collaborative environment combat community based participatory research cost effective disorder prevention disorder risk emergency service responder environmental chemical environmental stressor epigenomics ethnic diversity health science research human stem cells human tissue improved induced pluripotent stem cell interest intervention program low socioeconomic status member multidisciplinary next generation novel marker programs psychosocial public health relevance racial diversity research study response skills social stressor urban public health

项目摘要

DESCRIPTION (provided by applicant) Situated in the heart of Detroit, the Wayne State University "Center for Urban Responses to Environmental Stressors" (CURES) is focused on understanding how exposures to stressors that are prevalent in the urban industrialized environment, both chemical and non-chemical, impact human health. Special emphasis is placed on life windows of heightened susceptibility to environmental exposure and vulnerable persons at risk for environmental disease (e.g., children and adults of low socio-economic status, older adults, immigrants, refugees, and first responders). The hypothesis of the CURES Center is that diseases that compromise the quality of life in an industrialized urban environment, such as Detroit, occur as a consequence of dynamic interactions among an individual's genetic and epigenetic make-up, nutritional status, and environmental stressors, which include chronic low-level toxicant exposures as well as psycho-social and physical stressors, that re-program key cellular regulatory networks to favor pathogenesis. Four disease-oriented research interest groups serve as interdisciplinary hubs for population and basic scientists and community members interested in the role of environmental exposure in 1) immune disorders, 2) metabolic disease, 3) cancer, and 4) mental health disturbances. The Transdisciplinary/Translational Integration team (TRANSIT) works with community advisors to apply an integrated transdisciplinary approach to solving environmental health problems. The Integrative Health Sciences Facility Core guides Center researchers transitioning toward translational research studies and provides stem cell and human biospecimen services. The Exposure Signatures Facility Core enables Center members to apply integrated, state-of-the-art genomic, epigenomic, proteomic, and bioinformatic strategies to environmental health science research. The Community Outreach and Engagement Core provides for bi-directional exchange between the urban community at risk for environmental illness and Center members. CURES also sponsors programs focused on career and new project development. The CURES Center is a dynamic transdisciplinary research team that is dedicated to environmental disease prevention and creating a cleaner and healthier living and working environment in the city of Detroit.

描述（由申请人提供）