Center For Urban Responses to Environmental Stressors (CURES)

城市环境压力应对中心 (CURES)

基本信息

批准号：
9049259
负责人：
Melissa A Runge-Morris
金额：
$ 92.48万
依托单位：
WAYNE STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-06-05 至 2017-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9049259
关键词：
Address Adult Affect Animals Basic Science Bioinformatics Blood Chemicals Child Chronic Cities Collaborations Communities Community Outreach Complex Core Facility Development Disease Elderly Environment Environmental Exposure Environmental Health Environmental Illness Environmental Policy Environmental Pollutants Environmental Risk Factor Epidemiology Epigenetic Process Exposure to Fostering Gene Expression Genes Genetic Genomics Goals Health Health Sciences Heart Human Immigrant Immune System Diseases Immune system Individual Integrative Medicine Interest Group Leadership Learning Life Malignant Neoplasms Mental Health Mentors Metabolic Diseases Metabolism Modeling Molecular Profiling Monitor Neonatal Nutritional status Pathogenesis Persons Pilot Projects Policies Policy Maker Population Population Heterogeneity Predisposition Process Proteomics Public Health Quality of life Refugees Research Research Personnel Research Project Grants Resources Risk Role Science Scientist Services Spottings Testing Toxic Environmental Substances Toxicant exposure Translational Research Universities Vulnerable Populations Work base biobank career career development collaborative environment combat community based participatory research cost effective disorder prevention disorder risk emergency service responder environmental chemical environmental stressor epigenomics ethnic diversity health science research human stem cells human tissue improved induced pluripotent stem cell interest intervention program low socioeconomic status member multidisciplinary next generation novel marker programs psychosocial public health relevance racial diversity research study response skills social stressor urban public health

项目摘要

DESCRIPTION (provided by applicant) Situated in the heart of Detroit, the Wayne State University "Center for Urban Responses to Environmental Stressors" (CURES) is focused on understanding how exposures to stressors that are prevalent in the urban industrialized environment, both chemical and non-chemical, impact human health. Special emphasis is placed on life windows of heightened susceptibility to environmental exposure and vulnerable persons at risk for environmental disease (e.g., children and adults of low socio-economic status, older adults, immigrants, refugees, and first responders). The hypothesis of the CURES Center is that diseases that compromise the quality of life in an industrialized urban environment, such as Detroit, occur as a consequence of dynamic interactions among an individual's genetic and epigenetic make-up, nutritional status, and environmental stressors, which include chronic low-level toxicant exposures as well as psycho-social and physical stressors, that re-program key cellular regulatory networks to favor pathogenesis. Four disease-oriented research interest groups serve as interdisciplinary hubs for population and basic scientists and community members interested in the role of environmental exposure in 1) immune disorders, 2) metabolic disease, 3) cancer, and 4) mental health disturbances. The Transdisciplinary/Translational Integration team (TRANSIT) works with community advisors to apply an integrated transdisciplinary approach to solving environmental health problems. The Integrative Health Sciences Facility Core guides Center researchers transitioning toward translational research studies and provides stem cell and human biospecimen services. The Exposure Signatures Facility Core enables Center members to apply integrated, state-of-the-art genomic, epigenomic, proteomic, and bioinformatic strategies to environmental health science research. The Community Outreach and Engagement Core provides for bi-directional exchange between the urban community at risk for environmental illness and Center members. CURES also sponsors programs focused on career and new project development. The CURES Center is a dynamic transdisciplinary research team that is dedicated to environmental disease prevention and creating a cleaner and healthier living and working environment in the city of Detroit.

描述（由申请人提供）韦恩州立大学（Wayne State University）位于底特律的心脏地带，“城市对环境压力源的反应中心”（治疗）致力于了解如何在化学和非化学性，影响人类健康的城市工业化环境中向压力源进行暴露。特别重点是对环境暴露易感性易感性以及面临环境疾病风险（例如，社会经济低下的儿童和成年人，老年人，移民，难民和第一反应者的儿童和成年人）的易感性的窗户。 The hypothesis of the CURES Center is that diseases that compromise the quality of life in an industrialized urban environment, such as Detroit, occur as a consequence of dynamic interactions among an individual's genetic and epigenetic make-up, nutritional status, and environmental stressors, which include chronic low-level toxicant exposures as well as psycho-social and physical stressors, that re-program key cellular regulatory networks to favor发病机理。四个面向疾病的研究兴趣小组是人群和基础科学家和社区成员的跨学科枢纽，对环境暴露在1）免疫疾病中的作用感兴趣，2）代谢疾病，3）癌症和4）心理健康障碍。跨学科/转化整合团队（运输）与社区顾问合作，将综合的跨学科方法应用于解决环境健康问题。综合健康科学设施核心指南中心研究人员向翻译研究过渡，并提供干细胞和人类生物循环服务。暴露签名设施核心使中心成员能够将综合，最先进的基因组，表观基因组，蛋白质组学和生物信息学策略应用于环境健康科学研究。社区宣传和参与核心提供了面向环境疾病风险的城市社区与中心成员之间的双向交流。治疗方法还赞助了专注于职业和新项目开发的计划。治疗中心是一个动态的跨学科研究团队，致力于预防环境疾病，并在底特律市创造更清洁，更健康的生活和工作环境。