Administrative Core

行政核心

• 批准号: 8619368
• 负责人: Melissa A Runge-Morris
• 金额: $ 18.17万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-05 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8619368
• 关键词: Achievement; Adult; Affect; Back; Basic Science; Bioinformatics; Chemicals; Child; Chronic; Cities; Communication; Communities; Community Outreach; Core Facility; Data; Databases; Development; Disease; Dreams; Educational workshop; Effectiveness; Elderly; Electronic Mail; Ensure; Environment; Environmental Exposure; Environmental Health; Environmental Illness; Environmental Risk Factor; Epigenetic Process; Event; Exposure to; Funding Opportunities; Genetic; Genomics; Health; Health Sciences; Heart; Human; Immigrant; Immune System Diseases; Individual; Interest Group; Internet; Lasers; Lead; Leadership; Life; Malignant Neoplasms; Mental Health; Mentors; Metabolic Diseases; Needs Assessment; Nerve; Nutritional status; Occupational; Pathogenesis; Personal Satisfaction; Persons; Pilot Projects; Population; Predisposition; Proteomics; Public Health; Quality of life; Refugees; Research; Research Personnel; Research Project Grants; Risk; Role; Scientist; Services; Structure; Surveys; Toxicant exposure; Transcend; Translating; Translational Research; Trust; Universities; Voice; Work; Workplace; arm; base; career; disorder prevention; emergency service responder; environmental chemical; environmental stressor; epigenomics; experience; feeding; health science research; human stem cells; innovation; interest; low socioeconomic status; meetings; member; programs; psychosocial; racial and ethnic; research study; response; socioeconomics; stressor; success; urban public health; web site

Situated in the heart of Detroit, the Wayne State University "Center for Urban Responses to Environmental Stressors" (CURES) is focused on understanding how exposures to stressors that are prevalent in the urban industrialized environment, both chemical and non-chemical, impact human health. Special emphasis is placed on life windows of heightened susceptibility to environmental exposure and vulnerable persons at risk for environmental disease (e.g., children and adults of low socio-economic status, older adults, immigrants, refugees, and first responders). The hypothesis of the CURES Center is that diseases that compromise the quality of life in an industrialized urban environment, such as Detroit, occur as a consequence of dynamic interactions among an individual's genetic and epigenetic make-up, nutritional status, and environmental stressors, which include chronic low-level toxicant exposures as well as psychosocial and physical stressors, that re-program key cellular regulatory networks to favor pathogenesis. Four disease-oriented research interest groups serve as interdisciplinary hubs for population and basic scientists and community members interested in the role of environmental exposure in (1) immune disorders, (2) metabolic disease, (3) cancer, and (4) mental health disturbances. The Transdisciplinary/Translational Integration team (TRANSIT) works with community advisors to apply an integrated transdisciplinary approach to solving environmental health problems. The Integrative Health Sciences Facility Core guides Center researchers transitioning toward translational research studies and provides stem cell and human biospecimen services. The Exposure Signatures Facility Core enables Center members to apply integrated, state-of-the-art genomic, epigenomic, proteomic, and bioinformatic strategies to environmental health science research. The Community Outreach and Engagement Core provides for bi-directional exchange between the urban community at risk for environmental illness and Center members. CURES also sponsors programs focused on career and new project development. The CURES Center is a dynamic transdisciplinary research team that is dedicated to environmental disease prevention and creating a cleaner and healthier living and working environment in the city of Detroit.

位于底特律市中心的韦恩州立大学“城市环境响应中心”， 压力源”（治愈）的重点是了解如何暴露于压力，是普遍存在于城市 工业化环境，包括化学和非化学环境，影响人类健康。特别强调 关于对环境暴露高度敏感性的生命窗口和面临风险的脆弱人群， 环境疾病（例如，社会经济地位低下的儿童和成人、老年人、移民， 难民和第一反应者）。治愈中心的假设是，损害健康的疾病 生活质量在工业化的城市环境，如底特律，发生的结果，动态 个体的遗传和表观遗传组成、营养状况和环境之间的相互作用 压力源，包括长期接触低水平有毒物质以及心理和身体压力源， 重新编程关键的细胞调节网络以促进发病机制。四种疾病导向的研究兴趣 各小组是人口和基础科学家以及感兴趣的社区成员的跨学科中心 环境暴露在（1）免疫紊乱，（2）代谢性疾病，（3）癌症和（4） 心理健康问题跨学科/翻译整合团队（TRANSIT）与 社区顾问应用综合跨学科的方法来解决环境健康问题 问题综合健康科学设施核心指导中心研究人员向 转化研究研究并提供干细胞和人类生物标本服务。曝光 Signatures Facility Core使中心成员能够应用集成的、最先进的基因组、表观基因组、 蛋白质组学和生物信息学战略，以环境健康科学研究。社区外联 参与核心为处于风险中的城市社区提供了双向交流， 环境疾病和中心成员。治愈还赞助计划，重点是职业和新的 项目开发。治愈中心是一个充满活力的跨学科研究团队，致力于 预防环境疾病，并在中国创造一个更清洁、更健康的生活和工作环境。 底特律市。