Administrative Core

行政核心

• 批准号: 8619368
• 负责人: Melissa A Runge-Morris
• 金额: $ 18.17万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-05 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8619368
• 关键词: Achievement; Adult; Affect; Back; Basic Science; Bioinformatics; Chemicals; Child; Chronic; Cities; Communication; Communities; Community Outreach; Core Facility; Data; Databases; Development; Disease; Dreams; Educational workshop; Effectiveness; Elderly; Electronic Mail; Ensure; Environment; Environmental Exposure; Environmental Health; Environmental Illness; Environmental Risk Factor; Epigenetic Process; Event; Exposure to; Funding Opportunities; Genetic; Genomics; Health; Health Sciences; Heart; Human; Immigrant; Immune System Diseases; Individual; Interest Group; Internet; Lasers; Lead; Leadership; Life; Malignant Neoplasms; Mental Health; Mentors; Metabolic Diseases; Needs Assessment; Nerve; Nutritional status; Occupational; Pathogenesis; Personal Satisfaction; Persons; Pilot Projects; Population; Predisposition; Proteomics; Public Health; Quality of life; Refugees; Research; Research Personnel; Research Project Grants; Risk; Role; Scientist; Services; Structure; Surveys; Toxicant exposure; Transcend; Translating; Translational Research; Trust; Universities; Voice; Work; Workplace; arm; base; career; disorder prevention; emergency service responder; environmental chemical; environmental stressor; epigenomics; experience; feeding; health science research; human stem cells; innovation; interest; low socioeconomic status; meetings; member; programs; psychosocial; racial and ethnic; research study; response; socioeconomics; stressor; success; urban public health; web site

Situated in the heart of Detroit, the Wayne State University "Center for Urban Responses to Environmental Stressors" (CURES) is focused on understanding how exposures to stressors that are prevalent in the urban industrialized environment, both chemical and non-chemical, impact human health. Special emphasis is placed on life windows of heightened susceptibility to environmental exposure and vulnerable persons at risk for environmental disease (e.g., children and adults of low socio-economic status, older adults, immigrants, refugees, and first responders). The hypothesis of the CURES Center is that diseases that compromise the quality of life in an industrialized urban environment, such as Detroit, occur as a consequence of dynamic interactions among an individual's genetic and epigenetic make-up, nutritional status, and environmental stressors, which include chronic low-level toxicant exposures as well as psychosocial and physical stressors, that re-program key cellular regulatory networks to favor pathogenesis. Four disease-oriented research interest groups serve as interdisciplinary hubs for population and basic scientists and community members interested in the role of environmental exposure in (1) immune disorders, (2) metabolic disease, (3) cancer, and (4) mental health disturbances. The Transdisciplinary/Translational Integration team (TRANSIT) works with community advisors to apply an integrated transdisciplinary approach to solving environmental health problems. The Integrative Health Sciences Facility Core guides Center researchers transitioning toward translational research studies and provides stem cell and human biospecimen services. The Exposure Signatures Facility Core enables Center members to apply integrated, state-of-the-art genomic, epigenomic, proteomic, and bioinformatic strategies to environmental health science research. The Community Outreach and Engagement Core provides for bi-directional exchange between the urban community at risk for environmental illness and Center members. CURES also sponsors programs focused on career and new project development. The CURES Center is a dynamic transdisciplinary research team that is dedicated to environmental disease prevention and creating a cleaner and healthier living and working environment in the city of Detroit.

位于底特律中心的韦恩州立大学“城市环境响应中心” 应激源“(治疗)侧重于了解在城市中普遍存在的应激源是如何暴露的。 工业化环境，无论是化学的还是非化学的，都影响着人类的健康。特别强调的是 关于对环境暴露高度敏感的寿命窗口和易患癌症的人 环境疾病(例如，社会经济地位低的儿童和成人、老年人、移民、 难民和急救人员)。治疗中心的假设是，危害人类健康的疾病 在工业化的城市环境中，如底特律，生活质量是动态变化的结果 个体的遗传和表观遗传构成、营养状况和环境之间的相互作用 应激源，包括慢性低水平毒物暴露以及心理社会和身体应激源， 对关键的细胞调控网络进行重新编程，以利于发病机制。四个以疾病为导向的研究兴趣 团体是人口、基础科学家和感兴趣的社区成员的跨学科中心 环境暴露在(1)免疫紊乱、(2)代谢疾病、(3)癌症和(4)中的作用 精神健康问题。跨学科/翻译整合团队(TRANSPORT)与 社区顾问应用跨学科的综合方法来解决环境健康问题 有问题。综合健康科学设施核心指导中心研究人员向 翻译研究研究并提供干细胞和人类生物样品服务。曝光率 签名工具核心使中心成员能够应用集成的、最先进的基因组、表观基因组学、 环境健康科学研究的蛋白质组学和生物信息学战略。社区外展服务 和参与度核心为处于风险中的城市社区之间提供双向交流 环境疾病和中心成员。Caures还赞助专注于职业和新职业的项目 项目开发。治疗中心是一个充满活力的跨学科研究团队，致力于 预防环境疾病，创造更清洁、更健康的生活和工作环境 底特律市。