Administrative Core

行政核心

基本信息

批准号：
8619368
负责人：
Melissa A Runge-Morris
金额：
$ 18.17万
依托单位：
WAYNE STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-06-05 至 2017-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8619368
关键词：
Achievement Adult Affect Back Basic Science Bioinformatics Chemicals Child Chronic Cities Communication Communities Community Outreach Core Facility Data Databases Development Disease Dreams Educational workshop Effectiveness Elderly Electronic Mail Ensure Environment Environmental Exposure Environmental Health Environmental Illness Environmental Risk Factor Epigenetic Process Event Exposure to Funding Opportunities Genetic Genomics Health Health Sciences Heart Human Immigrant Immune System Diseases Individual Interest Group Internet Lasers Lead Leadership Life Malignant Neoplasms Mental Health Mentors Metabolic Diseases Needs Assessment Nerve Nutritional status Occupational Pathogenesis Personal Satisfaction Persons Pilot Projects Population Predisposition Proteomics Public Health Quality of life Refugees Research Research Personnel Research Project Grants Risk Role Scientist Services Structure Surveys Toxicant exposure Transcend Translating Translational Research Trust Universities Voice Work Workplace arm base career disorder prevention emergency service responder environmental chemical environmental stressor epigenomics experience feeding health science research human stem cells innovation interest low socioeconomic status meetings member programs psychosocial racial and ethnic research study response socioeconomics stressor success urban public health web site

项目摘要

Situated in the heart of Detroit, the Wayne State University "Center for Urban Responses to Environmental Stressors" (CURES) is focused on understanding how exposures to stressors that are prevalent in the urban industrialized environment, both chemical and non-chemical, impact human health. Special emphasis is placed on life windows of heightened susceptibility to environmental exposure and vulnerable persons at risk for environmental disease (e.g., children and adults of low socio-economic status, older adults, immigrants, refugees, and first responders). The hypothesis of the CURES Center is that diseases that compromise the quality of life in an industrialized urban environment, such as Detroit, occur as a consequence of dynamic interactions among an individual's genetic and epigenetic make-up, nutritional status, and environmental stressors, which include chronic low-level toxicant exposures as well as psychosocial and physical stressors, that re-program key cellular regulatory networks to favor pathogenesis. Four disease-oriented research interest groups serve as interdisciplinary hubs for population and basic scientists and community members interested in the role of environmental exposure in (1) immune disorders, (2) metabolic disease, (3) cancer, and (4) mental health disturbances. The Transdisciplinary/Translational Integration team (TRANSIT) works with community advisors to apply an integrated transdisciplinary approach to solving environmental health problems. The Integrative Health Sciences Facility Core guides Center researchers transitioning toward translational research studies and provides stem cell and human biospecimen services. The Exposure Signatures Facility Core enables Center members to apply integrated, state-of-the-art genomic, epigenomic, proteomic, and bioinformatic strategies to environmental health science research. The Community Outreach and Engagement Core provides for bi-directional exchange between the urban community at risk for environmental illness and Center members. CURES also sponsors programs focused on career and new project development. The CURES Center is a dynamic transdisciplinary research team that is dedicated to environmental disease prevention and creating a cleaner and healthier living and working environment in the city of Detroit.

韦恩州立大学底特律的心脏地带”城市对环境的回应中心压力源”（治疗）的重点是了解如何向城市中普遍存在的压力源暴露化学和非化学的工业化环境会影响人类健康。特别重点在生活窗户上，对环境暴露的敏感性增强和有风险的脆弱者环境疾病（例如，社会经济状况低下的儿童和成年人，老年人，移民，难民和急救人员）。固化中心的假设是损害疾病底特律等工业化城市环境中的生活质量是由于动态而发生的个人的遗传和表观妆容，营养状况和环境之间的相互作用压力源包括慢性低级毒物暴露以及心理和身体压力源，重新编程的钥匙细胞调节网络有利于发病机理。四个面向疾病的研究兴趣小组充当人口和基础科学家和社区成员感兴趣的跨学科枢纽在（1）免疫疾病，（2）代谢疾病，（3）癌症和（4）中环境暴露的作用心理健康障碍。跨学科/翻译集成团队（运输）与社区顾问采用综合跨学科方法来解决环境健康问题。综合健康科学设施核心指南中心研究人员过渡到翻译研究并提供干细胞和人类生物测量服务。曝光签名设施核心使中心成员能够应用综合的，最先进的基因组，表观基因组学，环境健康科学研究的蛋白质组学和生物信息学策略。社区宣传参与核心提供了有风险的城市社区之间的双向交流环境疾病和中心成员。治疗疗法还赞助了专注于职业和新的计划项目开发。治疗中心是一个动态的跨学科研究团队，致力于环境疾病预防，并在底特律市。