Center for Urban Responses to Environmental Stressors (CURES)

位于底特律市中心，环境健康科学“身份”的中心城市反应 环境压力（CURES）是了解环境暴露对健康的影响， 复杂的化学和非化学污染物在底特律的城市景观。我们的战略愿景是 提供领导，以确定，评估和减轻环境健康问题的密切合作， 社区和环境政策制定者。CURES组建了一支独特的跨学科团队， 现有的和新的环境卫生科学家和社区合作伙伴，以解决主要的环境问题， 底特律的种族和民族多样化人口面临的健康挑战。我们假设“现代” 疾病（例如，心血管疾病，癌症，糖尿病），损害居民的生活质量， 在工业化城市环境中，如底特律，是动态相互作用结果 在一个人的遗传和表观遗传组成，营养状况和环境压力， 重新编程关键的细胞网络以利于发病。CURES推进NIEHS 2012-2017战略 通过培养与底特律城市社区的紧密联系，应用翻译和跨学科的 团队研究的方法来解决复杂的环境健康问题，并通过寻找来源， 环境卫生差距。治愈正在我们地区产生影响。我们的研究人员和社区 合作伙伴迅速协调地对我们附近出现的严重卫生危机作出反应; 2015年至2016年，密歇根州弗林特的铅流域污染灾难。为了创造一个通往健康底特律的大门， CURES的短期目标是：1）加强现有的伙伴关系，并继续发展新的伙伴关系 在治愈和底特律社区之间; 2）与他们合作，确定主要的环境 健康威胁底特律的弱势群体; 3）进行高度综合的机械，流行病学， 和社区参与的研究，解决城市环境暴露对人类的影响， 健康; 4）建立治愈的能力，以实现其研究目标，提供设施的核心， 优化，以满足其成员和种子资金的需求，以支持试点项目，探讨可行性， 新的研究领域; 5）通过以下方式增强治愈对环境健康科学领域的影响 为新的和已建立的调查人员提供指导，支持他们的专业目标， 他们在环境健康研究中发挥领导作用。我们的长期目标是：1）提高我们的 社区合作伙伴的努力，以提高社区的认识和促进方案， 社区和2）制定适当的战略，基于治疗研究，为政策提供信息，以便 减轻与城市环境接触有关的风险。我们认为，治愈是最佳的 定位于创新团队科学机会的“底层”，这些机会最有希望 在我们的有生之年实现城市环境病的早期发现、预防和最终根除。

Situated in the heart of Detroit, the environmental health sciences “identity” of the Center for Urban Responses to Environmental Stressors (CURES) is to understand the health impacts of environmental exposures to complex chemical and non-chemical contaminants in Detroit's urban landscape. Our strategic vision is to provide leadership to identify, evaluate, and mitigate environmental health concerns in close collaboration with the community and environmental policy makers. CURES has assembled a unique interdisciplinary team of established and new environmental health scientists and community partners to address major environmental health challenges facing Detroit's racially and ethnically diverse population. We hypothesize that “modern-era” diseases (e.g., cardiovascular disease, cancer, diabetes) that compromise the quality of life of residents living in an industrialized urban environment, such as Detroit, occur as a consequence of dynamic interactions among an individual's genetic and epigenetic make-up, nutritional status, and environmental stressors, which re-program key cellular networks to favor pathogenesis. CURES advances the NIEHS 2012-2017 Strategic Plan by nurturing strong bonds with Detroit's urban community, applying translational and interdisciplinary team-research approaches to solve complex environmental health problems, and by seeking the sources of environmental health disparities. CURES is making an impact in our region. Our researchers and community partners responded rapidly and coordinately to a serious emerging health crisis in our immediate vicinity; the 2015-2016 lead watershed contamination disaster in Flint, Michigan. To create a gateway to a healthy Detroit, CURES' short-term goals are to: 1) strengthen existing partnerships and continue to develop new ones between CURES and the Detroit community; 2) in collaboration with them, identify the chief environmental health threats to Detroit's vulnerable populations; 3) conduct highly integrated mechanistic, epidemiological, and community-engaged research that addresses the impact of urban environmental exposures on human health; 4) build the capacity of CURES to accomplish its research goals by providing facility cores that are optimized to meet the needs of its members and seed funds to support pilot projects to explore the feasibility of new areas of study; and 5) enhance the impact of CURES on the field of environmental health science by providing mentoring to new and established investigators that supports their professional goals and prepares them for leadership roles in environmental health research. Our long-term goals are to 1) enhance our community partners' efforts to increase community awareness and facilitate programs for a healthier community and 2) develop appropriate strategies, based on CURES research, to inform policy so as to mitigate the risks associated with urban environmental exposures. We believe that CURES is optimally positioned on "the ground floor" of innovative team science opportunities that have the greatest promise to realize the early detection, prevention, and eventual eradication of urban environmental disease in our lifetime.