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Center for Urban Responses to Environmental Stressors (CURES)

城市环境压力应对中心 (CURES)

基本信息

批准号：
9563390
负责人：
Melissa A Runge-Morris
金额：
$ 7.17万
依托单位：
WAYNE STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-06-05 至 2022-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9563390
关键词：
Abate Address Adult Adverse effects Affect Age Age Distribution Air Pollution Area Asthma Awareness Cardiovascular Diseases Characteristics Chemical Exposure Chemicals Child Cities Coke Collaborations Communities Complex Core Facility Development Diabetes Mellitus Disasters Disease Early Diagnosis Elderly Environment Environmental Exposure Environmental Health Environmental Impact Environmental Policy Epidemiology Epigenetic Process Ethnic Origin Exposure to Floor Funding Generations Genetic Geography Goals Health Heart Heart Diseases Heavy Metals Housing Human Immigrant Immune System Diseases Individual Industrialization Lead Lead Poisoning Leadership Light Link Liver diseases Locales Malignant Neoplasms Mentors Metabolic Diseases Michigan Microbiology Mission Modernization National Institute of Environmental Health Sciences Neighborhoods Nutritional status Obesity Particulate Pathogenesis Personal Behavior Petroleum Pilot Projects Policies Policy Maker Pollution Population Heterogeneity Positioning Attribute Prevention Quality of life Race Refugees Renaissance Research Research Personnel Research Training Respiration Disorders Risk Role Science Scientist Secure Seeds Silicon Dioxide Social Interaction Source Strategic Planning Tars Universities Vision Vulnerable Populations Water Work base career consumer product cost design diet and exercise empowered environmental chemical environmental stressor ethnic diversity ethnic minority population experience gene environment interaction health disparity innovation land use lead exposure low socioeconomic status member pollutant programs psychosocial racial diversity resilience response socioeconomics stressor wasting

项目摘要

Situated in the heart of Detroit, the environmental health sciences “identity” of the Center for Urban Responses to Environmental Stressors (CURES) is to understand the health impacts of environmental exposures to complex chemical and non-chemical contaminants in Detroit's urban landscape. Our strategic vision is to provide leadership to identify, evaluate, and mitigate environmental health concerns in close collaboration with the community and environmental policy makers. CURES has assembled a unique interdisciplinary team of established and new environmental health scientists and community partners to address major environmental health challenges facing Detroit's racially and ethnically diverse population. We hypothesize that “modern-era” diseases (e.g., cardiovascular disease, cancer, diabetes) that compromise the quality of life of residents living in an industrialized urban environment, such as Detroit, occur as a consequence of dynamic interactions among an individual's genetic and epigenetic make-up, nutritional status, and environmental stressors, which re-program key cellular networks to favor pathogenesis. CURES advances the NIEHS 2012-2017 Strategic Plan by nurturing strong bonds with Detroit's urban community, applying translational and interdisciplinary team-research approaches to solve complex environmental health problems, and by seeking the sources of environmental health disparities. CURES is making an impact in our region. Our researchers and community partners responded rapidly and coordinately to a serious emerging health crisis in our immediate vicinity; the 2015-2016 lead watershed contamination disaster in Flint, Michigan. To create a gateway to a healthy Detroit, CURES' short-term goals are to: 1) strengthen existing partnerships and continue to develop new ones between CURES and the Detroit community; 2) in collaboration with them, identify the chief environmental health threats to Detroit's vulnerable populations; 3) conduct highly integrated mechanistic, epidemiological, and community-engaged research that addresses the impact of urban environmental exposures on human health; 4) build the capacity of CURES to accomplish its research goals by providing facility cores that are optimized to meet the needs of its members and seed funds to support pilot projects to explore the feasibility of new areas of study; and 5) enhance the impact of CURES on the field of environmental health science by providing mentoring to new and established investigators that supports their professional goals and prepares them for leadership roles in environmental health research. Our long-term goals are to 1) enhance our community partners' efforts to increase community awareness and facilitate programs for a healthier community and 2) develop appropriate strategies, based on CURES research, to inform policy so as to mitigate the risks associated with urban environmental exposures. We believe that CURES is optimally positioned on "the ground floor" of innovative team science opportunities that have the greatest promise to realize the early detection, prevention, and eventual eradication of urban environmental disease in our lifetime.

坐落在底特律的心脏地带，环境健康科学“身份”中心的城市反应